Epigenetic fingerprints link early-onset colon and rectal cancer to pesticide exposure - Nature Medicine An analysis of exposome traits in patients with early-onset colorectal cancer (CRC) (<50 years) compared with late-onset CRC (≥70 years) based on epigenetic markers shows that pesticide usage, in p...

Why are we seeing so much early-onset colorectal cancer?
The correlation with pesticide exposure and its epigenetic signature, adjusted for all known risk factors. (doesn't establish cause and effect)
nature.com/articles/s41...

🔬 Un estudio del @vhio.bsky.social publicado en Nature Medicine analiza por primera vez cómo el exposoma (entorno y estilo de vida) puede influir en el cáncer colorrectal en menores de 50 años a través de cambios en el ADN.

NEW 📄! Our last Nature Medicine paper, led by @silvanamaas.bsky.social and @seoaneja.bsky.social , identifies picloram (herbicide) as a novel risk factor on early-onset colorectal cancer ( #eoCRC), while confirming well-known risk factors. www.nature.com/articles/s41.... #exposome #epigenetics +

Relacionan los cambios provocados por dieta, tabaco y exposición a pesticidas con el desarrollo de cáncer colorrectal en menores de 50 años Un equipo del Vall d'Hebron Instituto de Oncología, en Barcelona, publica un estudio que aborda el impacto del exposoma –cambios en el estilo de vida y factores ambientales– en el cáncer colorrectal d...

➡️Un equipo de @vhio.bsky.social relaciona los cambios provocados por dieta, tabaco y exposición a pesticidas con el desarrollo de cáncer colorrectal en menores de 50 años

🗨️ Robin Mesnage: "Se necesita más trabajo, en concreto, con datos de exposición directa" sciencemediacentre.es/relacionan-l...

A @natmed.nature.com : un estudi liderat pel VHIO, amb José Antonio Seoane i Silvana Maas, vincula canvis epigenètics per la dieta, el tabac i l’exposició a pesticides amb el càncer colorectal en menors de 50 anys.
➡️ https://linke.to/NatureMedSeoane
#AECCVHIO @caixaresearch.bsky.social

also like to thank the editor, @ulrikeharjes.bsky.social, for her constant support throughout the review process in @natmed.nature.com @natureportfolio.nature.com

Very proud of our amazing team at @cancercompbiolab.bsky.social, and especially of @silvanamaas.bsky.social, who led this study and drove the project from start to finish

Early-onset CRC incidence is rising, and we don't know why. Using methylation marks, we link different exposures, like diet, smoking and a pesticide, to early- onset CRC. This work comes from a collaboration with Elena Elez's team at @vhio.bsky.social

Epigenetic fingerprints link early-onset colon and rectal cancer to pesticide exposure - Nature Medicine An analysis of exposome traits in patients with early-onset colorectal cancer (CRC) (<50 years) compared with late-onset CRC (≥70 years) based on epigenetic markers shows that pesticide usage, in p...

Delighted to share our new paper which has just been published in Nature Medicine. www.nature.com/articles/s41...

This is figure 1, which shows a high-resolution environmental model of pesticide risk across Peru, designed to support spatial cancer epidemiology.

An analysis in Nature Health reveals spatial patterns of pesticide exposure and liver tissue-derived molecular signatures across Peru, establishing links between pesticide usage and cancer insurgence at the national scale. go.nature.com/41hOBAK 🧪

Accelerating discovery of cancer causes for prevention in the era of rising early-onset cancers Rising early-onset cancers challenge existing frameworks for understanding and managing cancer. This perspective outlines a roadmap for addressing this challenge by advancing the discovery of cancer causes, cancer risk assessment, and cancer preventability characterization.

Now online! Accelerating discovery of cancer causes for prevention in the era of rising early-onset cancers

Distinctive DNA sequence features define epigenetic longevity of inflammatory memory Tissues harbor memories of inflammation, which heighten sensitivity to diverse future assaults. Whether and how these adaptations are sustained through time and cell division remain poorly understood....

I am very pleased with our latest paper showing that cells can remember past injury for a long time! Here a simple interpretable AI was used as a discovery tool to pinpoint the DNA code and biological mechanism. Big foundation models failed. www.science.org/doi/10.1126/...

Epigenetic memory of colitis promotes tumour growth - Nature Colonic stem cells retain a memory of inflammation following disease resolution and there is a mechanistic link between chronic inflammation and malignancy, suggesting potential strategies to mitigate...

It’s well known that inflammation increases cancer risk, but how?

The answer: the epigenome "remembers" inflammation and primes stem cells for cancer.

Here is our paper: nature.com/articles/s41...
And a special shoutout to the lead author
@snaga13.bsky.social

A 🧵

🧬Continuem celebrant els 25 Anys del Projecte Genoma Humà!

🗣️Descobreix com va ser la creació del primer llibre de la vida, de la mà d'un dels seus creadors: el Dr. @ewanbirney.bsky.social

🗓️08 d'abril, 19h. CosmoCaixa

📝Inscripcions: cosmocaixa.org/es/p/ewan-bi... @easigen-eu.bsky.social #ICTSNews

Why are so many young people getting cancer? What the data say Clues to a modern mystery could be lurking in information collected generations ago.

The rates of more than a dozen cancers are increasing among adults under the age of 50. What are the reasons behind it?

go.nature.com/4cKxhLN

👇 Still a couple of days to apply to join our amazing team as a Research Scientist / Software Developer.

Apply if you want to build and maintain reproducible pipelines for large-scale genomic analysis to support our study of breast cancer cis-regulatory signatures and JASPAR, among other things.

What makes HR+ breast cancer tumors immune-cold?
New work shows how ER signaling hijacks LCOR, suppressing tumor immunogenicity.
Our PI @seoaneja.bsky.social participates on this study led by @tceliaterrassa.bsky.social, uncovering a target to sensitize tumors to ICB. www.jci.org/articles/vie...

With the start of our new study trying to find causes of bowel cancer in young people hitting the headlines today: www.bbc.co.uk/news/article... I'm so glad to see bold efforts to raise awareness, like this giant 5x3m poster on the Croydon station platform I pass by on my to the lab each day

Century-old tumours could reveal why more young people are getting bowel cancer - BBC News Bowel cancer in people under the age of 50 is increasing worldwide and scientists are striving to find out why.

Read about our plans to analyse the century long archive at St Mark's Hospital to understand why more young people are being diagnosed with bowel cancer @trevorgraham.bsky.social

www-bbc-co-uk.cdn.ampproject.org/c/s/www.bbc....

🚀 Ready to take your career to the next level❓

8–10 fully funded PhD fellowships now open for Life Sciences & Medical students!
Apply now and be the next to turn cancer discoveries into cures  👉 https://linke.to/PhDfellowships25_VHIO

📅 Deadline: 28 November
#SOMMVHIO @cerca.cat

Wellcome Connecting Science Cancer Genomic Epidemiology 2026 Course dates: 16-18 February Location: Wellcome Genome Campus, UK Application deadline: 3 November 2025 Apply now Image description: A group of course participants seated in a classroom. A speaker is standing at the front of the room, holding a microphone, and is addressing the room.

Are you a cancer scientist looking to strengthen your genomics epidemiology skills and knowledge?

Join experts at our #CancerEpi2026 course to transform your understanding of cancer causes and prevention.

🗓️ 16-18 February 2026
Apply by 3 November

📎bit.ly/41mRDnD

#OncSky #GeneSky 🧪🖥️🧬

Meet our exceptional training team for #CancerEpi2026 💫

Field experts will guide you through how to use the best genomics tools and approaches to detect cancer mutations.

🗓️ 16-18 February 2026
Apply by 3 November - bursaries available

📎 bit.ly/41mRDnD
#OncSky #GeneSky #CancerSky 🧪🖥️🧬

Last week, pre-doctoral researchers @juanravm.bsky.social and @mariabuxi.bsky.social attended #CCEsumschool25 to showcase some of our group's research 👏🏼
Thanks to @vhio.bsky.social and @cancercoreeurope.bsky.social for this valuable opportunity for the next generation of cancer researchers 🔬

Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

Un algoritmo epigenético rastrea el origen del cáncer y predice su progresión Un equipo científico hispano-británico halla una 'caja negra' del cáncer que puede ayudar a desvelar la procedencia de los tumores y anticipar su evolución

Un algoritmo epigenético rastrea el origen del cáncer y predice su progresión

@jengreitz.bsky.social l & my lab want to co-hire a computational biologist/biostatistician with project management expertise to help map the regulatory code of the human genome and discover genetic mechanisms of disease.

Details below
careersearch.stanford.edu/jobs/computa...

Plz RT

Are you looking for a statistics/ML postdoc? Come to work with @antonis02.bsky.social and me in the NEMO study, an international collaboration aiming to detect ovarian cancer earlier through cutting-edge multi-omics, funded by the Alliance for Cancer Early Detection.
www.cam.ac.uk/jobs/researc...

📢 We have an open position at University of Geneva for a PhD student with CS/Math/Physics background to study adaptive immune responses using deep learning. If interested please contact me directly!

2025-040-01 Bioinformatics Scientist - VHIO Under the leadership of Josep Tabernero, VHIO is an internationally recognized cancer center. Its multidisciplinary, collaborative model drives scientific progress and innovative cancer treatments.

We are hiring!

We are searching for a motivated bioinformatics scientist interested in joining our team!

Apply below:

jobs.vhio.net/jobs/6203915...

Atul Butte died yesterday.
The world lost a giant.
A big bear of a man.
With a huge smile.
With love for everyone.
With energy that could power a room.
I loved everything about Atul.
I loved how he was always happy.
I loved how excited he was about science and helping people.