🚨 Applications are open for the 32nd Annual NIA Summer Training Course on aging research, Sept 8–12 at Buck Institute!
Free + focused on junior faculty & postdocs.
Deadline: July 1.
Details 👉 www.americanagingassociation.org/additional-a...
#AgingResearch #Geroscience #NIASummerCourse

Congratulations to Barbara Nikolajczyk, Ph.D, winner of the 2025 Women in AGE Mentoring Award!
Honoring her dedication to mentorship in the aging research community.
#AGEAnnualMeeting2025 #MentorshipMatters #WomenInScience #AgingResearch

Big congratulations to Christina Camell, Ph.D. for receiving the 2025 Women in AGE Scientific Achievement Award!
Her groundbreaking work in immune aging is shaping the future of aging science.
#AGEAnnualMeeting2025 #WomenInSTEM #AgingResearch #ScientificAchievement

I'm grateful to @beappbeapp.bsky.social and A4LI for featuring me in their Scientist Spotlight series! It was a lot of fun! Anyone who wants to check it out, here is the link! a4li.org/podcast/scie...

Have you registered to the AGE Meeting in AnchorAGE, Alaska? Registration rates will increase on April 1. Register Today! www.americanagingassociation.org/annual-meeting
#AGE2025

This week, I am excited to share with you my conversation with Emily Tom! I am so glad we crossed paths at the @americanaging.bsky.social AGE Meeting in San Antonio back in 2022.

Philly stands up for science! #standupforscience #standupforscience2025

Philly is Standing Up for Science : Girls just wanna have funding for scientific research #standupforscience2025

#StandUpForScience2025

Great turnout at the #standupforscience2025 rally! #boston🔬cc @universalhub

WATCH LIVE: 'Stand up for Science' rally with Bill Nye and others at Lincoln Memorial in Washington YouTube video by PBS NewsHour

#StandUpForScience2025! Our greatest and most useful minds, get loud. If you support the opposition, it’s because you chose harming people over helping them. You’re either a part of the problem or a part of the solution. #science #Politics #activism #protest #DoNoHarm #scientificmethod #scientists

Large crowd with protest signs in Montpellier, France

Speakers on stage at protest in Montpellier, France

Large crowd with protest signs in Montpellier, France

Large crowd with protest signs in Montpellier, France

Two protests in one day? ✊ Only in France! Montpellier came out strong to #StandUpForScience2025 this evening. The global community stands in solidarity with US academics, calling for #sciencenotsilence. 🌍 @standupforscience.bsky.social @standupforscifr.bsky.social

Amphibian expert shares about their work protecting species and raising awareness of these great animals, all on the basis of thoughtful science in conservation.

When budgets are slashed, this work is undermined.

#standupforscience2025

Well said from @ericverdin.bsky.social! The NIH is the heart of biomedical research in the US. The proposed cuts are unconscionable.

🌟Congratulations to AGE 2025 Early Career Scholar Alison Kochersberger, Buck Institute for Research on Aging!!
Learn More>> americanagingassociation.org/age-2025-ear...

Optimizing Longevity: From Research to Action | United States Senate Special Committee on Aging United States Senate Special Committee on Aging

TODAY at 3:30pm EST, there will be a special US Senate committee hearing on #aging! Click the link below to tune in to Optimizing Longevity: From Research to Action.

www.aging.senate.gov/hearings/opt...

Impact of NIH Funding Cuts on Longevity & Biomedical Research Recent NIH funding cuts, including overhead restrictions, are causing major concerns across the longevity and biomedical research community. We are collecting data on how these changes are affecting p...

AGE Members,

The Alliance for Longevity Initiatives (A4LI) is looking for feedback to better understand the impacts of the recent NIH funding cuts on the aging research community. Please consider participating in their survey:

forms.gle/sMAm7JgErJfP...

Whole lotta people going to lose their jobs at research universities. Indirect costs cover the salaries of a lot of office staff and facilities workers.

🌟 Join us in Anchorage, Alaska for the AGE 53rd Annual Meeting: New Frontiers in Aging Research! 🌟

This is an event you won’t want to miss!

📅 Save the Date & Be Part of the Conversation!

🚨 Attention all speakers, poster presenters, and travel award applicants! 🚨

The abstract portal is NOW OPEN!
Don’t miss your chance to be part of this exciting event!

Deadline to apply: February 7, 2025 ⏳
Apply today! 👇 #AGE2025 #AnchorAGE
americanagingassociation.org/annual-meeting

I would like to be added please!

Only 2 more days to apply for our Early Career Scholars Program! Don't miss out on this great opportunity!

Memory and Aging Center Grand Rounds Neuroimaging and Neuropathological Investigations of Alzheimer's Disease Clinical and Biological Heterogeneity Renaud La Joie, PhD Assistant Professor of Neurology University of California, San Franc...

UCSF Memory and Aging Center Grand Rounds
Monday, Dec 16, 2024
10 to 11 a.m. PT

"Neuroimaging and Neuropathological Investigations of Alzheimer's Disease Clinical and Biological Heterogeneity"
by
Renaud La Joie, PhD
@relajoie.bsky.social

Register 👉 calendar.ucsf.edu/event/mac-gr...

We found that low OXR1 levels in humans correlate with #Alzheimers, so we drove tau-induced toxicity in fly eyes, to see if we could rescue it with OXR1/retromer. Overexpression of OXR1 or retromer genes prevented this toxicity. Lots more to come from this, so stay tuned! Happy to discuss more 😊

We next wanted to see if enhancing the retromer rescues brain degeneration. Not only did it reduce degeneration in brains of flies that had lost OXR1, but it improved age-related #neurodegeneration as well.

We next found that OXR1 is expressed with proteins in the endolysosomal network. By staining fly brains, we found that loss of OXR1 causes loss of proteins in the #retromer complex, like VPS35. The retromer takes cargo from endosomes and traffics them for reuse, as opposed to breakdown.

We screened in flies for genes undergoing dietary restriction (DR) to find new regulators of longevity. A top candidate gene was called mustard, or OXR1 in humans. We found that DR upregulates OXR1 and is necessary for lifespan extension by DR. Overexpression of OXR1 extended lifespan in flies!

OXR1 maintains the retromer to delay brain aging under dietary restriction - Nature Communications Dietary restriction promotes healthy brain aging, but the mechanism is unknown. Here, the authors show that OXR1 is upregulated by dietary restriction and confers age-related neuroprotection by m...

Since I've met many new people on @bsky.app, I wanted to re-share this paper we published earlier this year in @naturecomms.bsky.social! We found OXR1, which regulates #longevity and #brainaging through neuronal endocytic recycling. Read below for a summary 👇
www.nature.com/articles/s41...
#GeroSky

β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain Madhavan et al. identify and characterize the selective regulation of protein solubility by the ketone body β-hydroxybutyrate (βHB) across a range of models. βHB exposure rescues cell-based and C. ele...

Our latest work: a new link between metabolism and proteostasis, relevant to Alzheimer's disease. Out today in Cell Chemical Biology as open access! Stay tuned for more discussion of what we found and what it means... @buckinstitute.bsky.social @cellpress.bsky.social
www.cell.com/cell-chemica...

Starter packs BIOLOGY General Science community https://go.bsky.app/HVYAMEA Research Institutions in Life Sciences https://go.bsky.app/LxXpcvJ LGBTQIA+ in STEM https://go.bsky.app/BFc4wgf LGBTQIA+ in STEM 2 h...

Thank you so much to whoever put this very comprehensive list of #science Bsky starter packs together. This is just amazing: docs.google.com/document/d/1...