We are looking for an experienced light microscopy specialist, motivated to support our users in the Advanced Light Microscopy Facility at EMBL Heidelberg.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j... -closing date 11 May 2026 @eurobioimaging.bsky.social @globalbioimaging.bsky.social
These two books contain the sum total of all human knowledge
A wrap-up of @events.embl.org
#EESBioOsc Biological Oscillators meeting! sites.google.com/view/dynamic...
Unfortunately @events.embl.org #EESBioOsc is coming to an end. As usual it was a scientific treat, and seeing @sarapozzi.bsky.social present her work was a highlight of the meeting. Nicely done!
As always, a pleasure working with @davidemazza.bsky.social and his fantastic lab and learn from them about the dynamic mysteries of p53. Great effort from @emabiong.bsky.social with @sarapozzi.bsky.social and @alessialoffreda.bsky.social ... thank you all!
There is more to come- stay tuned!
And voilà.
The simple model matches exactly what we observe:
• Enhanced p53 accumulation when NF-κB and p53 are co-activated (vs p53 alone)
• No discernible p53 activation when NF-κB is activated alone
Once you consider the whole system, the apparent mystery disappears. (6/n)
This is where even a simple model becomes useful.
Activating NF-κB perturbs a specific portion of the signaling network. The model embeds that perturbation in the full system and lets us simulate three scenarios: what if we activate NF-κB alone, p53 alone, or both together? (5/n)
Naively, you might expect that activating NF-κB alone would also lead to a big increase p53.
But, "mysteriously", experimentally that’s not what happens. (4/n)
NF-κB is activated by cytokines like TNF-α, while p53 is activated by γ-irradiation.
Here’s our key observation: We show that NF-κB induces TP53 gene expression. So when you co-activate NF-κB and p53, you get higher p53 levels. (3/n)
This work is also a nice example of how even simple mathematical models are incredibly useful in biological systems.
They provide a rigorous description of what a perturbation actually does — within the context of the full network, not in isolation. (2/n)
So grateful to my buddy the great @davidemazza.bsky.social and all the contributors from our teams to this joint effort to unravel NF-κB–p53 crosstalk. Davide’s thread nicely explains the main findings — here’s a short side note from me 🧵👇 (1/n)
What we found surprised us: these two transcription factors cooperate at the molecular level, yet this cooperation produces functional antagonism.
Even more intriguingly, inflammatory signals can impair DNA repair by reshaping the temporal dynamics of p53.
If you’re curious, here’s the story 👇
🧵 I’m very happy to share a new preprint from the @samuzambrano.bsky.social group and ours — a project driven by @emabiong.bsky.social, a PhD student bold enough to tackle a question at the interface of our two expertises: how the biological oscillators p53 and NF-κB talk to each other.
New preclinical work in #ScienceSignaling reveals how #Tcells respond in real time to signaling inputs of varying intensities and could shed further light on how these cells become activated in the context of immunity and inflammation. https://scim.ag/4qN2h1d
#FluorescenceFriday
Proud of our the last paper @cellcommlab.bsky.social & 1st one of @jboixcampos.bsky.social
We continue to study #CellMigration & how cells decide where to go: ↖️↗️⬇️?
(movie of the actin #cytoskeleton)
Full www.science.org/doi/10.1126/...
@focalplane.bsky.social @science.org 🧪🔬
Un fantástico tónico intelectual como dice Savater, que por lo demás está en las antípodas de bigotes.
Blog post: Chance favors the (theoretically) prepared mind
Data is big, machines are learning, so what good is theory anyway? Isn't most discovery driven by serendipity anyway, with theory mostly a "post-mortem"? I argue that this view discounts the value of theory.
open.substack.com/pub/arjunraj...
Extremely funny to call the pope “holier-than-thou”
Fig. 6: Mathematical model
Network Medicine is entering a new phase: one that demands we rethink how we study, model and ultimately treat complex diseases.
www.sciencedirect.com/science/arti...
#ComplexSystems #NetworkScience #Medicine #MedSky 🧪🧬🌐
🧵 1/
Hay un poco de batiburrillo entre sanciones y aranceles en el artículo. Lo último es algo más novedoso. No tengo muy claro que obedezca a una tendencia histórica irreversible, pero con Trump erro todos mis pronósticos :-)
Interesante pero un poco impreciso, no? Las sanciones y las vallas europeas anteceden con mucho a Trump.
Halloween is a nice day to share our new site, where you can find more info on what our team does. It can briefly be summarized as Dynamical Systems (in) Biology: sites.google.com/view/dynamic...
How do dynamics of signalling molecules skew cell fate decisions? With this review we try to move our first steps in the signalling dynamics field, together with the expert lead of @samuzambrano.bsky.social! Kudos to Fulvio, Sara and Erika for their excellent work!
As usual it was a pleasure and lots of fun to collaborate with @davidemazza.bsky.social and his lab in this effort led by Fulvio Bonsignore, Sara Pozzi and Erika Aloi.
We discuss the evidence from the main areas where this connection is being established (immunity, response to DNA damage, growth factors and developmental cues) outlining the common methodologies used and potential future directions of this emerging dynamic point of view on how cells make decisions.
Cells respond to stimuli by activating signaling pathways with a surprising variety of dynamics. Why? As we review here, there is growing evidence connecting dynamics with specific cell fate decisions www.frontiersin.org/journals/cel...
New @nejm.org
One-shot gene therapy for a type of congenital deafness enabled some children to hear for the first time, and 3 of 12 kids achieved normal hearing
www.nejm.org/doi/full/10.1056/NEJMoa2400521
How dit life originate in our planet? How can we create it in the lab?Our @royalsocietypublishing.org Theme Issue "Origins of Life: the possible and the actual", coedited with @sfiscience.bsky.social C Kempes and Susan Stepney is out! royalsocietypublishing.org/toc/rstb/202... @manlius.bsky.social
