Summary of main findings. Left: Main contributions of the somatosensory inputs to the generation of motor activity in M1. Cortical state generation is independent from somatosensory inputs. Right: Schematic Vm modulations of an M1 neuron in an intact mouse (IT Vm) and in a nerve cut mouse (NC Vm) during a Quiet to Movement transition. The removal of forelimb inputs did not impact the occurrence of quiet/active periods in the membrane potential, but (1, vertical line) reduced pre-movement input; (2, gray box) reduced Vm correlations with ongoing forelimb movement; and (3, horizontal line) disrupted the reach reversal potential.

How does somatosensory input to the #MotorCortex contribute to limb movement? This study shows that loss of #somatosensory inputs disrupts voluntary forelimb movements & motor cortex neuronal dynamics, highlighting the role of somatosensory input in motor control @plosbiology.org 🧪 plos.io/3QcbXph

Example forelimb reaching movements of a mouse, and simultaneous recording of the membrane potential in the primary motor cortex.

▶️ In our new @plosbiology.org study with James Poulet, we show somatosensory contributions to M1 Vm in a forelimb reaching task.

▶️ Surgical removal of somatosensation impacted movement encoding, Vm regulation and its transition to active state, and more!

▶️ Learn more: doi.org/10.1371/jour...

▶️ Heike Stein from Sorbonne Université will be the 4th keynote speaker at NeuroControl2026!

▶️ NeuroControl 2026, the conference on the physiology and engineering of limb and prosthesis closed-loop control!

Register and submit your abstract: neurocontrol.sciencesconf.org

▶️ Henri Lorach from Université de Lausanne will be the 3rd keynote speaker at NeuroControl2026!

▶️ NeuroControl 2026, the conference on the physiology and engineering of limb and prosthesis closed-loop control!

Register and submit your abstract: neurocontrol.sciencesconf.org

First time seeing "for real" the new metro at #Saclay. The line will open (with a higher speed I hope) on October this year.

▶️ Daniel Häufle from Tübingen Universität will join us as a keynote speaker at NeuroControl2026!

▶️ NeuroControl 2026, the conference on the physiology and engineering of limb and prosthesis closed-loop control!

Register and submit your abstract: neurocontrol.sciencesconf.org

🎉 We will have a talk by Daniel Huber at the NeuroControl2026 conference!

➡️ Register: neurocontrol.sciencesconf.org

M2 Systems Neuroscience: from cells to brain functions

🧠 We are pleased to announce that applications for the M2 Systems Neuroscience at the University Paris-Saclay are officially open 🎉
www.universite-paris-saclay.fr/formation/ma...

@univparissaclay.bsky.social @neuropsi.bsky.social

We invite applications for postdoctoral researchers with strong expertise in in vivo electrophysiology and circuit neuroscience to join our team at the Paris Brain Institute (ICM).

If you are a PhD student or post-doc who wants to learn everything about #electrophysiology or #imaging, consider registering to the Paris Spring school in optical imaging and electrophysiology, that will take place in the center of Paris 11-23 May 2026. Application deadline Feb 2nd
parisneuro.ovh

yes, but do you have a web interface, or only smartphone apps?

We are organizing a conference on closed-loop limb control, looking at both robotic and physiological control.
▶️ Register, submit your abstract!

🦾/💪 Interested in the physiology of motor control? In robotics? In neuroprosthetics?

▶️ Join us in NeuroPSI for NeuroControl 2026, the conference on the physiology and engineering of limb and prosthesis closed-loop control!

▶️ Register and submit your abstract: neurocontrol.sciencesconf.org

A prefrontal cortex map based on single-neuron activity - Nature Neuroscience The authors mapped spontaneous and choice activity across mouse prefrontal cortex. The activity maps aligned with intrinsic connectivity rather than anatomical subregions, suggesting that connectivity...

Main postdoc study out! We can redefine prefrontal cortex regions with single-unit activity! Grateful to @carlenlab.bsky.social and @weltgeischt.bsky.social who made this crazy project real. Thanks to all co-authors, collaborators, and reviewers.
www.nature.com/articles/s41...

🦾 🧠 Are you interested in building and experimenting with the second version of our mouse forelimb prosthesis? Apply to our Post-Doc position at Université paris-Saclay.

Neuroscientists with interest for engineering, and engineers with interest for neurosciences all welcome! Apply now 🔽🔽🔽

Really happy to join NeuroPSI at Paris Saclay to lead a research group funded by an ERC Consolidator grant #ERCCoG . We'll study the origins of the vertebrate brain using shark embryos. 🦈 🧠 Reach out if you are interested in joining the team 🤍

Et Idoia QUINTANA à @neuropsi.bsky.social !

We have opened a call for a post-doctoral researcher !
Our team @touchmovelab.bsky.social researches strategies to provide direct cortical feedback during brain-machine interface control of an upper limb prosthesis in the mouse model.

The hidden danger of Biorender

(& the death of scientific illustration)

A short thread 🧵

C'est visiblement mal étudié encore, mais ça semble équivalent au tabac ou pire. Respirer des produits de combustion n'est jamais bon... Voici un exemple de méta-analyse en français:
doi.org/10.1016/j.rmra.2024.11.128

Enduring reduction of resting state functional connectivity (FC) of parvalbumin-positive interneurons (PV-INs) after stroke. Top left: Experimental timeline, with the cranial optical window implanted one week before the first imaging session. Imaging time point at −1 (PRE), 2, 5, 8, 14, 21, and 28 days after stroke. Top right: Left, representative image sequence of cortical PV-IN activity before stroke. The black dot indicates bregma. L: lateral; M: medial; R: rostral; C: caudal (Scale bar, 1 mm). Right, wide-field calcium imaging field-of-view aligned with the surface of the Allen Institute Mouse Brain atlas. The green area on the left hemisphere locates the damaged region. Yellow squares represent cortical areas defined in both left (L, contralesional) and right (R, ipsilesional) hemispheres. Red dot indicates bregma (Scale bar, 1 mm). Middle row: Pairwise Pearson’s correlation coefficients of cortical activity were visualized as averaged correlation matrices for each imaging time point after hemodynamic correction. Bottom row: Network diagrams of statistically significant FC alterations after 2, 5, 8, 14, 21, or 28 days from injury. Blue and red lines denote significant hyper-correlation and hypo-correlation compared to prestroke values, respectively.

How to restore #motor function after #stroke? This study shows in mice that a combination of #RoboticRehabilitation & non-invasive gamma band #neuromodulation improves motor recovery by restoring movement-related oscillations & parvalbumin #interneuron dynamics @plosbiology.org 🧪 plos.io/4n7QJng

🤯 👁️ Did you know the primary visual cortex tracks head movements even in complete darkness?

Guy Bouvier and colleagues managed to decode multiple head movement variables in V1 without light in the room, and discovered two distinct brain sources delivering these signals!

Read more in PNAS 🔽🔽

Evenement à diffuser pour la fête de la science en @iledefrance.bsky.social @poncerlab.bsky.social
@bathellierlab.bsky.social @clairewyart.bsky.social

Cortical control of a forelimb prosthesis in mice Robotic upper-limb prostheses aim to restore the autonomy of paralyzed patients and amputees. So far, advances in this field have relied on monkey pre-clinical and human clinical research. Here, we re...

4/4
➡️ Read our manuscript on the link below 🔽🔽🔽
➡️ Many thanks to our collaborators at L2S @centralesupelec.bsky.social , and to all members of the @touchmovelab.bsky.social‬ for their key input to this project.
➡️ Funding from Fondation 3DS and @agencerecherche.bsky.social

Average dominant movement of the prosthesis leading to a rewarded lick. Left: along dimension 1 of the control space. Right: dimension 2. Light curves: individual movements during one session. Thick curve: average over the session.

3/4 As learning progressed, the mice learned to coordinate the prosthesis movements across dimensions, and they managed to consolidate a dominant prosthesis trajectory that led to rewards.

Left: 2D control subspace. Each dimension is driven by the modulation of one of the neurons recorded in M1. Right: average learning curve, in terms of licks that provided water to the mouse.

2/4 Our prosthesis can perform movements in a 3D space next to the body of the mice, that control it via a chronic invasive brain-machine interface. We show that the mice can drive it in a 2D subspace, while some mice managed to control it also in a 3D space.

Left: the upper-limb prosthesis can collect water from a tank, and bring it close to the mouth. Right: skeleton of the prosthesis with 4 DOF. THis prosthesis relies on Bowden cables.

1/4 Today we introduce the first upper limb prosthesis for the mouse model, controlled by a brain-machine interface! We show that mice can control this prosthesis via a brain-machine interface to solve a rewarded task.

🚨 New preprint + thread 🧵
We've gone back to studying motoneuron control principles and their applications & here's paper #1:

A proof-of-concept study showing that people with tetraplegic spinal cord injury can control up to 2DoF from a single intramuscular implant

www.medrxiv.org/content/10.1...

Never thought I’d see the day when LinkedIn is the biggest driver of engagement in our papers, but we live in some strange times.

6/6 This is all thanks to the incredibly talented and passionate Anton Dogadov, who carried this whole study!

Thanks for feedback on our first version of the paper from @gbouvier.bsky.social vier.bsky.social‬ at @neuropsi.bsky.social, Jean-François Léger @ibensens.bsky.social and many others!