Wed., April 22; 9:00 AM - 12:00 pm; Poster Section 11, Poster Board 8, Poster Number 7029:
“Engineering isogenic models harboring resistance mechanisms to the latest-generation EGFR inhibitor in non-small cell lung cancer.” (4/4)

The PRISM Lab | LinkedIn The PRISM Lab | 390 followers on LinkedIn. 900+ Cancer Cell Line Screening and Predictive Modeling of Drug Response | Developed by the Broad Institute of MIT and Harvard, PRISM (Profiling Relative Inh...

Sunday, April 19; 4:20 pm; Ballroom 6 CF - Upper Level:
“PRISM AIR: A high-throughput platform for functional validation of ADC targets and antibody candidate prioritization” Details about PRISM posters can be found at www.linkedin.com/company/pris.... Visit PRISM at booth #3017. (3/4)

Attending #AACR? Stop by these Cancer Dependency Map activities:

Saturday, April 18; 12:30 - 2:00 pm; Ballroom 6 DE - Upper Level - Convention Center: Join the DepMap team in celebrating their 2026 AACR Team Science Award at the Award Lecture. www.aacr.org/about-the-aa... (2/4)

Cancer Dependency Map Consortium launches Phase 3 to accelerate next-generation therapeutics The next stage of the academic-industrial partnership aims to expand beyond cancer vulnerabilities to investigate cancer resistance, surface targets, and high-dimensional readouts.

The Cancer Dependency Map Consortium is entering its third phase, accelerating the next generation of cancer therapies. (1/4)

The recording of "Network-based rare variant association for complex diseases" by @snz20.bsky.social is now available: youtu.be/KO-6M5lXTlI. This talk is part of @broadinstitute.org's MPG Primer series. For more info, check out broad.io/MPGPrimer.

The recording of "Epigenomic profiling and AI-guided cancer diagnostics" by @sbenfatto.bsky.social is now available: youtu.be/eO4ywdRGDN4. This talk is part of @broadinstitute.org's MPG Primer series. For more info, check out broad.io/MPGPrimer.

Base editing repairs mutation and liver function in mouse model of Zellweger spectrum disorder The base editing enzyme used in this study is the same one that fixed Baby KJ Muldoon’s disease-causing mutation and saved his life in 2025.

Scientists corrected a genetic mutation that causes a rare, life-threatening condition, Zellweger spectrum disorder, in mice. The study points toward an optimal base editor enzyme with implications for other genetic diseases. broad.io/ZSD-News

Leukemia cells use a sugar-coated protein to hide from the immune system Targeting this protein, called CD43, could offer a new path to treatment for leukemia and other cancers.

Leukemia and possibly other cancers could be using sugary proteins on their cell surface to shield themselves from immune attack. New study points to potential cancer immunotherapy target. broad.io/CD43 @danafarbernews.bsky.social @mgbresearch.bsky.social

Scalable cell imaging method could help make drug safety testing faster, cheaper Researchers show that Cell Painting, an image-based cell profiling method, can reveal details of how drug candidates and other chemicals may harm cells.

New study shows the promise of Cell Painting, an AI-powered, scalable cell-imaging method, to make drug toxicity testing faster, cheaper, and more information-rich in human cells—potentially reducing failed clinical trials and animal testing.

Malaria-transmitting mosquitoes in South America are evolving to evade insecticides Sequencing of complete genomes of Anopheles darlingi mosquitoes in the Americas finds resistance may make them harder to kill.

The first ever large scale study of whole genomes from Anopheles darlingi -- a key malaria vector in the Americas -- reveals signs of emerging insecticide resistance. @jacobphd.bsky.social

Team #PROSPECT has revealed how the epigenome “remembers” inflammation, priming cells for cancer risk in mice.

We spoke with @snaga13.bsky.social and Jason Buenrostro about what these findings mean for patients, and what the future holds. Learn more: www.cancergrandchallenges.org/news/the-epi...

How inflammation may prime the gut for cancer A study in mice suggests that even intestinal cells that appear healthy may hold epigenetic “memories” of earlier bouts of inflammation that can promote colon cancer later in life.

Chronic gut inflammation leaves behind “molecular scars” that may raise the risk for developing cancer, according to a new study showing that epigenetic memory of colitis, along with a cancer-promoting mutation, can accelerate tumor growth in mice. @jbuenrostro.bsky.social

A new view into viruses in the body Analysis of some of the most common viruses hiding in the body shows how our genes influence the long-term effects of these viruses on our health.

By analyzing DNA data from over 900,000 people, a new study found that some of the most common viruses hiding in the body vary with age, sex, and the seasons — and that genes influence the long-term effects these viruses have on our health.

The Stanley Family Foundation has renewed its commitment to psychiatric research at Broad Institute, bringing its total investment to more than $1 billion. This funding has advanced schizophrenia/bipolar disorder research, opening new paths to therapies. broad.io/SC-News

Join us March 18 at 6PM ET in Cambridge, MA (or online) for a Broad Discovery Series talk with Heidi Greulich and Matthew Meyerson, “The story behind a new therapy for lung cancer patients.” Register: broadinstitute.swoogo.com/Discovery26

Improving Diagnosis of Aortic Stenosis with Genetics and AI - UCSF MedConnection Joint UCSF and Broad Institute study investigates genetic basis for development of of Aortic Stenosis.

A genetic variation has a big impact on who develops aortic stenosis, UCSF/@broadinstitute.org researchers found using a deep learning-based model. “These findings demonstrate the power of jointly analyzing cardiovascular structure and function.” Dr. James Pirruccello says. https://ucsfh.org/4bhJ3ea

Attention science/health reporters and editors: applications are open for Broad’s 2026 Media Boot Camp! Join us in Cambridge April 30–May 1 for a deep dive into emerging stories in biomedicine. Hotel & meals provided. Apply by Friday, March 20: broad.io/mediabootcamp

The recording of "New approaches and data sources for coding variant interpretation" by @ccassa.bsky.social is now available: youtu.be/8YiHnealbEc. This talk is part of @broadinstitute.org's MPG Primer series. For more info, check out broad.io/MPGPrimer.

Microbiota-mediated induction of beige adipocytes in response to dietary cues - Nature In mice, a low-protein diet leads to a gut-microbiota-driven remodelling of adipose tissue towards brown fat, showing that gut microorganisms have a role in detecting and responding to a lack of prote...

New study, in collaboration with Kenya Honda, out now in @nature.com. We show how a low protein diet drives a microbiota-dependent induction of thermogenic brown adipocytes via FXR & FGF21 pathways.

www.nature.com/articles/s41...

Gut bacteria rewire fat tissue to burn more energy Study reveals how the gut microbiome and diet work together to transform white fat cells into energy-burning beige fat in mice.

New research from @thexavierlab.bsky.social finds that the gut microbiome fine-tunes fat tissue in mice in response to diet, converting it from energy-storing fat to more energy-burning fat when dietary protein is low.

Rescheduled to March 18 at 6 pm ET. Register: broadinstitute.swoogo.com/discovery26

Free genetic testing program aims to improve medical care across Alabama Led by Southern Research, MyOme, and Broad Clinical Labs, the program provides participants with personalized health insights, enabling more informed and proactive healthcare decisions.

The Catalyst program, led by Alabama nonprofit Southern Research, Broad Clinical Labs, and MyOme, Inc., provides free genetic testing to adult residents across Alabama to improve medical care and address chronic disease.

Study reveals genetic balancing act between autoimmunity and cancer risk Researchers pinpoint genetic factors linked to both higher risk of a common autoimmune disorder and lower cancer risk

Large-scale FinnGen-based study by Reeve et al., just published in Nature Genetics, provides the most detailed genetic map of autoimmune hypothyroidism to date and reveals a surprising inverse relationship between hypothyroidism risk and skin cancer risk.
www.broadinstitute.org/news/study-r...

Study reveals genetic balancing act between autoimmunity and cancer risk Researchers pinpoint genetic factors linked to both higher risk of a common autoimmune disorder and lower cancer risk

Check out this great write-up of a recent study between the
@broadinstitute.org , University of Helsinki, and other institutions which has found more than 400 genetic markers that are linked to autoimmune hypothyroidism (AIHT). (1/4)

www.broadinstitute.org/news/study-r...

An animation of DNA strand above the text: Scientists sharpen genetic maps to help pinpoint DNA changes that influence human health traits and disease risk

How do genes impact disease risk? By rapidly testing hundreds of thousands of #DNA sequences, scientists at JAX, @broadinstitute.org and @yale.edu have identified specific genetic variations that contribute to blood pressure, cholesterol, blood sugar, and more.🧪🧬

https://go.jax.org/gene-maps-health

Study reveals genetic balancing act between autoimmunity and cancer risk Researchers pinpoint genetic factors linked to both higher risk of a common autoimmune disorder and lower cancer risk

The same genetic variants that heighten the risk of autoimmune hypothyroidism — the most common autoimmune disorder — may also lower cancer risk, according to a new study led by scientists at Broad, @helsinki.fi, and @mgbresearch.bsky.social. broad.io/AIHT-news

Scientists sharpen genetic maps to help pinpoint DNA changes that influence human health traits and disease risk By rapidly testing hundreds of thousands of DNA sequences, scientists have identified specific genetic variations that contribute to blood pressure, cholesterol, blood sugar, and more.

Pinpointing the exact noncoding variants driving locus-disease associations is an enduring challenge. Using MPRA, a @jacksonlab.bsky.social, Broad & @yaleschoolofmed.bsky.social team tested >220,000 variants in 5 cell types, resolving >13,000 and revealing mechanisms behind several disease traits.

Sabrina Camp, Kevin Bi and Eli Van Allen, MD, of Dana-Farber Cancer Institute

Research in Science Advances by @danafarbernews.bsky.social’s Sabrina Camp, Kevin Bi and Eli Van Allen, MD, revealed loss of the gene BAP1 activates a tumor-intrinsic interferon signaling program, highlighting immune evasion pathways as potential treatment targets. @broadinstitute.org bit.ly/4cEOFBl

Partially shared multi-modal embedding learns holistic representation of cell state - Nature Computational Science APOLLO is an autoencoder-based framework to integrate diverse data modalities while preserving both shared and modality-specific information. It enables predicting missing data modalities and identify...

📢Caroline Uhler and colleagues from Eric and Wendy Schmidt Center at @broadinstitute.org present APOLLO, a framework to integrate diverse data modalities, enabling predicting missing data modalities and identifying the influence of each modality on a phenotype. www.nature.com/articles/s43... 🖥️ 🧬

Identifying microbial protease allergens through protein language model-guided homology Thurimella et al. introduce a deep learning framework using protein language models to predict allergenic proteases in the microbiome. The model identified hundreds of candidate allergenic proteases i...

1/ Our paper is out today in @cp-cellsystems.bsky.social. We used protein language models and deep learning to identify candidate protease allergens in the human microbiome.

www.cell.com/cell-systems...