A brief guide to statistical analysis of grouped data in preclinical research - Nature Metabolism Clustering and nesting (C&N) arise in many preclinical studies, such as when animals are group-housed or share litters, or in cell culture. Ignoring C&N undermines the validity of analyses. Here, we explain how C&N arise, as well as valid designs and analyses.

#Throwback 🧪

COMMENT | A brief guide to statistical analysis of grouped data in preclinical research

@colbyvorland.bsky.social
L Golzarri-Arroyo
DB Allison

Isn’t nature pure magic? ✨❄️❄️

It’s another Meet the Member Monday!

This week I’m pleased to introduce 2 of our PhD students (both proud 🇧🇷!!) Erikles & Lucas!

Erikles is a veterinarian with a background in experimental biology. He’s leading our transgenic animal studies🐭 to understand causes & prevention of neural tube defects

The Often Overlooked Water Footprint of AI Models … and what that means for individuals, newsrooms, and journalists

Just got a glimpse of the water footprint of A.I. how was this not more widely discussed? Feels like I’ve being living in a cave 🤯 while some cities are already facing water shortages linked to data centers.

Easy reading generative-ai-newsroom.com/the-often-ov...

Manganese porphyrin [MnTE-2-PyP]5+ improves maternal and offspring glycemic homeostasis, placental morphology, and redox balance in diabetic pregnant rats Gestational Diabetes Mellitus (GDM) is a prevalent metabolic disorder during pregnancy, associated with oxidative stress and inflammation at systemic …

Excited to share our new paper! 🧬

Exploring how redox-modulating compounds can protect mothers and babies in diabetic pregnancies — a step toward new gestational therapies and long-term health.

Honored to be part of the amazing team behind this work! 💫

www.sciencedirect.com/science/arti...

Mouse (Mus musculus) 🐭 is the powerhouse of mammalian genetics, essential for studying embryogenesis, organ development and gene function using transgenic technologies. 📸 Image by Zhong Hua also featured on the cover of Developmental Biology textbook (11th edition) #ModelMonday

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research - Nature Metabolism This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental factors affecting circadian rhythms in metabolic studies in rodents.

#Throwback 🧪

REVIEW | The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research

S Deota, S Panda et al.

Promotional graphic for a special issue of the Journal of Experimental Biology titled "The Integrative Biology of the Gut." Guest editors are Carol Bucking, Matt Regan, and John Terblanche. The artwork features a stylized gut with segments representing diverse ecosystems—desert, forest, and river—symbolising the environmental and biological complexity of gut research. The journal’s logo appears in the bottom left corner.

New special issue from Journal of Experimental Biology

This issue considers the functional roles of the #gut, from the #cellular level to its interactions with other #organs and tissues, including its role in #ecophysiological and #biogeochemical processes.

journals.biologists.com/jeb/issue/22...

Connecting Researchers Through Bioimaging: Reflections from UCL’s BioImage Interest Group - FocalPlane Connecting Researchers Through Bioimaging: Reflections from UCL’s BioImage Interest Group -

📢New post on FocalPlane - Connecting Researchers Through Bioimaging: Reflections from UCL’s BioImage Interest Group

Courtney Lancaster @courtneyl7a7.bsky.social‬ reflects on the success of the BioImage Interest Group at UCL, offering a template for other communities.

As a representative, my goal is to create more spaces for communication and to foster scientific curiosity among ECRs 🚀

I know this is quite personal, but from my perspective, beyond all the practical skills, the PhD journey is about research. So why aren’t we, as societies and groups, stimulating this more? (Cont.)

I’ve been carrying a few “?” in my head lately 👇🏽👇🏽👇🏽

Talking with other early-career researchers, I keep noticing how many feel a bit disconnected from the research they’re doing — sometimes just following a plan they didn’t create or truly understand. (Cont.)

NIH announces end to funding for animal-only studies - Drug Discovery and Development Drug Discovery and Development covers strategies and technologies related to pharmaceutical research and development and drug formulation.

This is extraordinarily dangerous and will slow academic biomedical research and drug development. A total ban is on the horizon. www.drugdiscoverytrends.com/nih-announce...

Did you know June is Spina Bifida & Hydrocephalus Awareness Month in 🇨🇦?

Learn more from www.hydrocephalus.ca
& Spina Bifida families of 🇨🇦 sbcan.ca

And visit our lab’s website to see our work in this field made possible through the power of clinical & translational science research partnerships 🫱🏽‍🫲🏻

Happy International #ClinicalTrials Day! 🎉

Did you know that these trials are key in making sure new treatments are safe and effective? A big thank you to all the volunteers and professionals who make this possible. Your work paves the way for healthier tomorrows. 🙌

#PatientPower

The Young Embryologist Network Conference was amazing! So much inspiration seeing all the brilliant work 🧬 🔬 🌎! I could only attend virtually this year, but it’s now a top priority to be there in person next time. Huge congrats to the organizers — what a fantastic event! #YEN2025

Excited to see everyone at #YEN2025! Be sure to say hi and check out our new 3D Real-time Embryology module in action.

@yen-network.bsky.social

Congratulations to our co-president, Dr. Kristin Connor (@kconnor.bsky.social), for being awarded the Nick Hales Award by the International DOHaD Society. #DOHaD2025

Health Sciences research day 2025

First presentation of this big and beautiful project that I’m so proud to be leading!
Milestones that deserve to be eternalized!
💪🏽💪🏽💪🏽✨✨✨🚀🚀

Health in the age of disinformation Health misinformation (false or misleading data shared unintentionally) and disinformation (deliberately deceptive information) are not new, but the COVID-19 pandemic marked a turning point. The sense...

Disinformation spreads faster than facts in today's rapid information age. We've never been more vulnerable.

www.thelancet.com/journals/lan...

Hypothyroidism Alters Uterine Kisspeptin System and Activity Modulators in Cyclic Rats Hypothyroidism causes ovarian dysfunction and infertility in women and animals and impairs the hypothalamic expression of kisspeptin (Kp). However, kisspeptin is also expressed in the genital system, ...

✨ Kicking off the year strong! Thrilled to share our new paper showing that hypothyroidism reduces the uterine Kiss1/Kiss1r system, disrupting estrogen & progesterone signaling and uterine receptivity mediators across the rat estrous cycle✨

Check it out! www.mdpi.com/1422-0067/26...

Whyyy

🤭🤭🤭 fresh hihihi

research for a healthy start to live ✨✨