Somatic mutations in microglia brain cells (the same mutations as seen in cancer) are enriched in and may drive the neuroinflammation of Alzheimer's disease
@cellcellpress.bsky.social
cell.com/cell/fulltex...
We’re in the truly weird position where McSweeney had to go for giving the PM the advice to appoint Mandelson and Robbins had to go for not stopping him.
I’ve spent my career telling other people’s stories. Now, I’m telling my own.
I’m pleased to announce that my memoir, "WEIRD ERA: How Pitchfork Changed Music Forever," arrives December 1 via @fsgbooks.bsky.social
Pre-order here: tinyurl.com/weird-era
Can a single brain cell decide whether to eat or not? 🧠🪰
Turns out... yes. And we found it in the fruit fly.
A pair of neurons called SELKs (subesophageal leucokinin neurons) can drive feeding behavior in both directions. They promote it or suppress it. Here's how: 🧵
Rare sighting of a column chart taking a dip at Hove Beach.
#dataviz
Holy. Shit. This is Reid Wiseman's video he took with his iPhone while at the moon 🌙
Tremendously depressing read. Also: proper reporting.
open.substack.com/pub/londonce...
None of these are good scenarios for Starmer. Either there is a culture of fear between No10 and FCDO that overrides national security concerns (1) or No10 overrides national security concerns without telling Starmer (2) or Starmer has lied (3).
Sometimes I can't believe I get to write about my favorite stuff @lrb.co.uk but sometimes I do get to write about it. For example, the new one from @heavenlyamelia.bsky.social @skepwax.bsky.social I'm seeing them Friday! www.lrb.co.uk/blog/2026/ap...
New @currentbiology.bsky.social paper from Dr. Leila Elabbady on neural circuits that transform a touch stimulus into spatially targeted grooming.
Leila discovered a leg somatotopic map and used it to infer tactile receptive fields in the fly VNC connectome.
authors.elsevier.com/a/1mvu83QW8S...
Having been through DV a long time ago, the output is not a simple recommendation it is quite an involved file that details *redacted* and now holding a moderately senior compliance role I am astonished that the defence is "I didn't read the report." I cannot emphasise how sacked I'd be.
Done! 👍
Hit me up if you'd like to be added to this Starter Pack, or if there's someone you think should be on it. 🙋♀️🙋♂️
Hasn't been updated since November 2024!
go.bsky.app/S6FfsTp
No problem - just added them. FYI this post was originally from Nov 2024 and hadn't been updated since then - I know there's likely loads of new folk who should be on it.
🧠Sharing this Starter Pack again as the list has now reached 80 people! A great mix of Profs/PIs/Post-docs/PhDs/Technicians.
Please re-post so it can reach a wider audience as I'm sure there are more of us out there ☺️🦋
go.bsky.app/S6FfsTp
What was remarkable, at least to me, was that across both species the effects of neuronal ATGL loss on energy homeostasis were specific to males. This raises a lot of intriguing questions about sex differences in neuronal lipid metabolism. /8
Beyond delighted to share our amazing collaboration with Thierry Alquier's lab @alquierthierry.bsky.social on a conserved role for neuronal lipid droplets in regulating energy homeostasis in vivo led by Celena Cherian, Romane Manceau, Danie Majeur, and Colin Miller www.nature.com/articles/s42... /1
The victory of the opposition in Hungary yesterday, like the Polish election in 2023, is a victory for democracy, not just in Europe but around the world.
Fantastic to join the #EdinburghScienceFestival with our lab’s Stitch and Fly workshop!
We had a highly interactive, fully booked session discussing our research alongside fruit fly-inspired stitching!
Huge thanks to the PhD students in our lab and SBS public engagement team.
#Drosophila #Genetics
"To put it bluntly, an X post today receives less than 3% of the views a single tweet delivered seven years ago."
If you think it is necessary to be on Twitter to communicate your fact-based worldview, the reality is that worldview is being smothered.
Really enjoyed Project Hail Mary except the two tubes SIDE BY SIDE in the centrifuge instead of opposite each other 😵😵💫
Today in @nature.com we introduce INSTALL, which bypasses mammalian DNA immune sensing to enable non-viral DNA integration with recombinases—a step toward safe, and mutation-agnostic genome editing. 🧬 🧵 (1/13)
www.nature.com/articles/s41...
@harvardmed.bsky.social @mgbresearch.bsky.social
Thank you @senguptalab.bsky.social.
Sh*t happens. Despite your best efforts and intentions. Super stressful for all involved. But a masterclass from @scottishwaddell.bsky.social and Gaby Maimon in how to deal with this with scientific integrity and mutual respect. They'll work out the neuronal mechanisms at some point.
Thank you @ribeirocarlitos.bsky.social
Immense respect for handling this situation with this level of integrity. Mistakes happen. Science is a process.
NYTimes Headline: The Women Who Believe That Women Should Lose the Right to Vote Subhead: Adherents to biblical patriarchy support household voting: One household, one vote--the husband's. They say the idea is catching on.
The New York Times rolling up its sleeves to do the hard work of normalizing the idea that women should not have the right to vote.
A measured story about our new pet, the digital sphinx, in @thetransmitter.bsky.social.
www.thetransmitter.org/systems-neur...
The Greens have now overtaken both the Conservatives and Labour, according to the latest polling average
