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Posts by David Rind

Did you happen to bump into a lecture that does a better job than the McLean video. He was lecturing to people with more knowledge of the physics of aerodynamics than I have but was touching on things that never seemed adequately explained elsewhere. I'd really like to understand this better.

3 days ago 2 0 0 0
Institute for Clinical and Economic Review Releases White Paper on Accelerated Approval Pathway for Prescription Drugs - ICER New paper, developed with input from diverse stakeholders, outlines policy options to strengthen the FDA pathway.

New from Institute for Clinical and Economic Review (ICER) and Verdant Research: We revisited our 2021 white paper on FDA's accelerated approval pathway.
icer.org/news-insight...

4 days ago 5 3 1 1

Although there's been a lot of focus on how they combined trials of different drugs -- and it's reasonable to argue about this -- I think the bigger issue is that they treated a standardized mean difference as if it were a minimal clinically important difference. Jargony, but this is a problem.

5 days ago 1 1 0 0
Institute for Clinical and Economic Review Releases Draft Scope on Vaccines for Covid-19 - ICER Report will be subject of New England CEPAC meeting in June 2026; Draft Scoping Document open to public comment until December 2, 2025.

Institute for Clinical and Economic Review Releases Draft Evidence Report on Vaccines for Covid-19: tinyurl.com/4enrmhsf

2 weeks ago 2 2 0 0

I've clearly missed something about your backstory.

2 weeks ago 2 0 0 0
Institute for Clinical and Economic Review Publishes Final Evidence Report on Therapies for IgA Nephropathy - ICER Independent appraisal committee found a net health benefit for sibeprenlimab, atacicept, and Nefecon.

Institute for Clinical and Economic Review Publishes Final Evidence Report on Therapies for IgA Nephropathy: tinyurl.com/395xxjcy

3 weeks ago 1 1 0 0

Okay, but whom should we treat for LTBI? The guidelines that we should only test people who would be appropriate to treat doesn't match reality where many people tested are over 50 and likely were infected with TB when they were under age 5....

2 weeks ago 0 0 0 0

Men have really sensitive eardrums?

1 month ago 3 0 1 0

But have you shoveled a path to Sally's?

1 month ago 0 0 0 0
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#62: GLP-1s: Life-Changing Results… at What Cost? Podcast Episode · Live Long and Well with Dr. Bobby · 02/05/2026 · 51m

podcasts.apple.com/us/podcast/6...

2 months ago 1 1 0 0
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GLP-1 Weight Loss Drugs : Miracle Cure or Costly Mistake? ( Facts vs Hype )
GLP-1 Weight Loss Drugs : Miracle Cure or Costly Mistake? ( Facts vs Hype ) YouTube video by Live Long and Well With Dr. Bobby

youtu.be/EbV5YDRTuTI

2 months ago 1 1 0 0
Institute for Clinical and Economic Review Releases Evidence Report on Therapies for IgA Nephropathy - ICER All three therapies exhibit net health benefits, but uncertainties remain around the magnitude of long-term improvements in outcomes as well as safety; sibeprenlimab’s price far exceeds usual threshol...

Institute for Clinical and Economic Review Releases Evidence Report on Therapies for IgA Nephropathy: tinyurl.com/mumdu8d9

2 months ago 1 1 0 0

Would you consider calling for a national (or red state) health care providers strike?

2 months ago 0 0 0 0

Let's say I thought it was time to start organizing a physicians' job action in areas of some country where elected regional officials don't vote to prevent an unjustified war. How would I go about that?

3 months ago 0 0 0 0
Retired ICE agent breaks down deadly Minneapolis shooting
Retired ICE agent breaks down deadly Minneapolis shooting YouTube video by CBS Evening News

So a CBS Evening News reporter actually did a pretty solid breakdown of the ICE murder video, talking to a former agent who details all the ways Ross messed up. And yet: It didn’t air on the actual show tonight. CBS did post it to YouTube—and it has nearly 800k views already youtu.be/6ywLEESFDu0?...

3 months ago 4101 2113 108 109
Video

This afternoon, retired Army general Stanley McChrystal spoke at the retirement ceremony hosted by HRC for six trans service members who were forced out under Trump’s ban.

“I shouldn’t have to be thanked for being here. First off, we shouldn’t be here. This shouldn’t be happening.”

Full remarks:

3 months ago 3527 906 25 67
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With political savvy and outrage over drug prices, advocate David Mitchell was ahead of his time David Mitchell, who helped launch Patients for Affordable Drugs to raise awareness of high drug prices and seek to bring them down, died at age 75.

I was very sad to learn of the passing of David Mitchell,
a cancer patient who turned his own battle into a fight to make medicines more affordable. Here, @pharmalot.bsky.social gets at why Mitchell was so special.

www.statnews.com/2026/01/05/d...

3 months ago 21 11 0 2
Take Back Primary Care

Case on point:

Take Back Primary Care

By William M. Tierney, MD

Despite being the largest medical specialty, primary care's in crisis. There's a national shortage of 20,000+ #PrimaryCare physicians, & more leaving the field b/c adverse #Healthcare system issues.

link.springer.com/epdf/10.1007...

3 months ago 5 4 0 0
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I have no clue how we get from our current medical system to a functional system with good care and reasonable costs. But the current system is breaking, so I suspect we will need to make major changes as things fail. Single payer UHC will be one of the options as we rebuild.

3 months ago 0 0 0 0
physics crackpots: a 'theory'
physics crackpots: a 'theory' YouTube video by Angela Collier

With the Brown/MIT shooting, I keep thinking about @acollierastro.bsky.social 's YouTube about physics crackpots and whether this is what was going on. Worth watching in any case.

www.youtube.com/watch?v=11lP...

3 months ago 1 0 0 0
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Sarepta: Enough, For God's Sake

Sarepta: Enough, For God's Sake | Science | AAAS share.google/WcxLae5lKrqy...

5 months ago 3 1 0 0
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it was only a matter of time—like ninety minutes, max

7 months ago 472 35 55 5

I'm inappropriately proud of this. I usually can't spot these at all, and am never first. Got lucky with an early notification and a very easy duplication!

9 months ago 2 0 1 0

Bottom row, the first through third blots on the left are copied as the second through fourth blots on the right.

9 months ago 8 0 2 0
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The FDA and Gene Therapy for Duchenne Muscular Dystrophy This Viewpoint examines the appropriateness of FDA accelerated approval of novel gene therapies to treat boys with Duchenne muscular dystrophy following clinical trials with surrogate outcomes that di...

Posting this link now, for some reason....

jamanetwork.com/journals/jam...

9 months ago 1 0 0 0

Humility and grace are really important parts of being a caregiver in any situation, but particularly in an unfolding pandemic.

There is no chance you'll be right all the time. Admit that, accept it, and don't criticize others who are trying to do the same, even if you disagree with their choices.

9 months ago 0 0 0 0
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concern that you would be wrong lead you to be unable to act. Many of the choices would be proven correct.

One of the parts of the COVID pandemic I've found most disheartening is the criticism some have gotten from other experts for being wrong some of the time.

9 months ago 0 0 1 0

I'd missed what I noted in the fall and winter of 2020 was an important similarity:

Things that you thought were true/correct/best care were proven wrong over and over.

And yet, you had to accept that you needed to provide what you believed to be the best care at the time and not let the

9 months ago 1 0 1 0

Great piece.

I got a similar question from an intern in mid March of 2020 as the situation began to unfold in Boston. He asked if I thought there was anything I'd learned during the AIDS pandemic that was applicable to COVID.

I told him that I thought the situations were very different.

But...

9 months ago 1 0 1 0
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GRADE Certainty Ratings: Thresholds Rather Than Categories of Contextualization (GRADE Guidance 41) | Annals of Internal Medicine In 2017, the GRADE (Grading of Recommendations Assessment, Development and Evaluation) working group defined the certainty of evidence as the certainty that the true effect lies on one side of a thres...

www.acpjournals.org/doi/10.7326/...

9 months ago 1 0 0 0