This shows an antibody heavy chain successfully pairing with a surrogate light chain and signalling B cell progression. In contrast a non-pairing heavy chain fails to signal, the B cell stalls, and the suboptimal V gene is replaced by an upstream V to make a pairing heavy chain and rescue the B cell.

Delighted to share that our paper solving the age-old mystery of whether and how VH-replacement shapes the antibody repertoire is in @embojournal.org
www.embopress.org/doi/full/10....
Fantastic work from Harry White, @peterch405.bsky.social @babraham-bioinf.bsky.social @babrahaminst.bsky.social

Women in Pharmacology advert

👩‍🔬To celebrate International Women and Girls in Science Day yesterday, our team interviewed Dr Catherine Wilson!

We chatted to her about a range of topics surrounding being a Woman in Pharmacology - read her interview here: bit.ly/3COpzjZ

#Interview #Pharmacology #Women #Cambridge

Hi Rod, Please add me, I've just joined the platform.Thanks!

picture of girl and woman high-fiving with floating images of DNA, planets, circuit board, test tube, pendulum

First post: It is a joy to CELEBRATE 10th Anniversary of International Day of Women and Girls in Science
#IDWGS #WomenInScience #GirlsInSTEM
Celebrating women and girls who have broken barriers and paved the way for future scientists.
Let us continue to make our voices and talents heard and valued