Read the latest Special Topic on Endothelial Cell and Pericyte Homeostasis and Pathogenesis in JHC: "Role of the Pancreatic Islet Microvasculature in Health and Disease."
Click to read for FREE: bit.ly/4fihNMw
#capillary #diabetes #endothelialcell
"Intestinal Tuft Cells Are Enriched With Protocadherins."
Click to read: bit.ly/4hlyARd
#epithelium #gut #immunostaining
Human coronavirus OC43 infection remodels Connexin 43 mediated gap junction intercellular communication in vitro www.biorxiv.org/content/10.1101/2023.11....
Structural basis of connexin-36 gap junction channel inhibition www.biorxiv.org/content/10.1101/2023.12....
Orally Delivered Milk-Derived Nanovesicles Loaded with Connexin 43 Peptides forTargeted Cardiac Ischemia-Reperfusion Therapy www.biorxiv.org/content/10.1101/2025.01....
17β-Estradiol Counteracts Pathological Microtubule Remodeling To Enhance Cardiac Function www.biorxiv.org/content/10.1101/2025.01....
TGR5-mediated Ca2+ signaling in cholangiocytes www.biorxiv.org/content/10.1101/2025.01....
Targeting Runx1 protects against heart failure with preserved ejection fraction www.biorxiv.org/content/10.1101/2025.01....
Perilysosomal Ca2+ overload impairs autophagic degradation in β-cell lipotoxicity www.biorxiv.org/content/10.1101/2025.01....
(a) BSE-SEM photomontage of a human rib viewed in cross-section. Local variations in mineralisation density, Haversian canals, resorption spaces, and osteocyte lacunae can be detected. (b) Osteocyte lacunar density determined using BSE imaging. (c) A cement line between osteonal bone and interstitial bone. (d) The intertrabecular spaces in antler bone are occupied by primary osteons. Trabeculae (asterisks) and unremodelled islands of calcified cartilage (arrow) can be identified. (e) Topographical BSE-SEM. For each 90° sector of an annular BSE detector, a separate image is recorded containing information sensitive to the direction of apparent illumination (arrows). (f) Osteon pull-out under cyclic mechanical loading observed using SE imaging. (g) Cell surface detail of osteoblasts on the surface of parietal bone. (h) Osteoblasts appear to organise collagen fibrils through flat basal processes. (i) Hypermineralised osteocyte lacuna containing mineralised apoptotic debris. (j) Severely disorganised bone microstructure in melorheostosis. (k) Bone with (right) and without (left) osteocytes. (l) An osteocyte and associated canalicular network exposed by resin cast etching. (m) Howship’s lacunae: longitudinally extended resorption (LER; left) and reticulate patch resorption (RPR; right) lacunae. (n) Cryo-SEM. The combination of SE (above) and BSE (below) imaging provides morphological and compositional information. SE = secondary electron mode; BSE = backscattered electron mode
🧪 #Bone meets the scanning electron microscope 🦴🔬
Detailed description in Alt text
#MicroscopyMonday #science #biology #biomineralization #biomaterials #imaging #bioimaging #electronmicroscopy #mineral #collagen #apatite
www.nature.com/articles/s41...
Moesin activation controls bone resorption and tunneling nanotube-dependent osteoclast fusion www.biorxiv.org/content/10.1101/2024.05....
Did you know it’s Osteoclast Appreciation Day, today? It’s not really, I’m just kidding. But they’re my favourite cells, & don’t you think they deserve their own special day?
Mechanosensing by Piezo1 regulates osteoclast differentiation via PP2A-Akt axis in periodontitis www.biorxiv.org/content/10.1101/2024.09....
Pages 23-31 of 'Osteon/Osteoclast,'fast(ish) works made to help ease the mind, or allow the subconscious to breathe
Older camera, older images. I am shy of sharing them, as it seems an atypical artwork related to Gaster
But, for now, it seems the time to be shy is over. Better simply to be as I am
Psychological stress disturbs bone metabolism via miR-335-3p/Fos signaling in osteoclast www.biorxiv.org/content/10.1101/2024.02....
I really must start posting here - work and personal life have been crazy.
In the mean time enjoy this osteoclast - a bit like Bluesky joining together in clearance renewal.
An abstract depiction illustrating the processes of bone creation and dissolution, featuring contrasting textures and shades that symbolize the dynamic nature of these biological processes.
[osteoblast][osteoclast]
#synthart #synthography #art #aiart #abstractart
American Museum of Natural History
It’s nothing; your photomicrographs deserve to be shared. Besides being beautiful, they are part of valuable scientific work. I’m just starting out, but I already realize how challenging the world of science can be, which is why everything should be shared
Twitter is currently down in Brazil 🥹, so I’ve been following you closely on LinkedIn. I really enjoy your posts.
🦴🔬#Osteocyte – the master orchestrator of #bone #remodeling. ~42 billion in the average adult human skeleton, #osteocytes make up ~90–95% of all #cells within bone, interconnected by ~3.7 trillion dendritic projections with an estimated, total end-to-end length of 175,000 km 🔍
Dear Professor, every time I see your photomicrographs, I feel an immense desire to one day work with you. I am currently studying osteocytes here in Brazil. Wishing you a great day
Porra cara, eu amo muito a minha namorada