I whole-heartedly agree. I am on a constant quest to reclaim my vertical space in apps (looking at you, MS ribbon 👀).

A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

Ooooh. Cool new paper on origins of life. A simple 45-nucleotide RNA molecule that can perfectly copy itself.

www.science.org/doi/10.1126/...

Oben links Logo Fraunhofer in weiß; Bild eines tragbaren Messsystems in Form eines Koffers verbunden mit einer Art Flasche; Text unten: "Lebensmittelbetrug schnell erkennen. Neue Messtechnik für Produktschutz und Qualitätskontrolle"

Links: Bild eines mit Olivenöl gefüllten Glaskolbens. Rechts Text: Im Fraunhofer PREPARE-Projekt PUMMEL entwickeln Forschende ein System, mit dem sich falsch etikettierte Lebensmittel vor Ort identifizieren lassen. Etwa gefälschtes Olivenöl.

🔬Ein mobiles Gaschromatographie-Sensorsystem soll künftig helfen, Lebensmittelbetrug vor Ort zu erkennen. Drei Fraunhofer-Institute entwickeln das leicht bedienbare Gerät, das auch Analytik-Laien eine schnelle Bewertung ermöglicht. Mehr dazu: 🖇️ s.fhg.de/qxnv #Qualitätscheck #compliance

Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3 - Nature Chemistry In targeted protein degradation, a degrader molecule brings a neosubstrate protein proximal to a hijacked E3 ligase for its ubiquitination. Here, pseudo-natural products derived from (−)-myrtanol—iDeg...

paper alert🚨
Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3 - Published by the groups of Herbert Waldmann @waldido.bsky.social , Slava Ziegler and @georgwinter.bsky.social @cemm.oeaw.ac.at in @nature.com Chemistry
www.nature.com/articles/s41...

Feeling it.

Mols2grid 2.2.0 is out with full Marimo support 🎅 Huge thanks to @n283t.bsky.social for the contribution! See this for an example linking mols2grid selections with marimo's UI table: github.com/cbouy/mols2g...
N283T: x.com/tbsng_ktkm0923

Oh wow, I love Marimo. Will definitely check it out. Thanks a lot.

Comic. [Two people one one side of a pile of seven apples, next to person with long hair next to five apples.] PERSON: Okay, with my seven apples added to your five, we have… let’s se… twelve apples! PERSON 2 [with hands raised]: Incredible! Perfect agreement with the theory! [caption] Experimental Mathematicians

Apples

xkcd.com/3180/

RNA

XKCD got it right, again: xkcd.com/3056/

This week's #RDKit blog post shows how to create simple protein--ligand interaction diagrams.
I think there's potential to take this a bit further...
greglandrum.github.io/rdkit-blog/p...

“We only have a few minutes left so please keep your questions brief.”

“Thank you for your talk, before I ask my convoluted question and get to the point, please allow me to tell you my name, title, position, rank and academic biography…”

Looks fantastic, Ed.

OpenAI just updated ChatGPT to be able to use RDKit, a cheminformatics Python package.

OpenAI's president says this makes ChatGPT "useful for scientific work across health, biology, and chemistry," but it is hilariously still not good at chemistry (🧵)

#chemsky #AI ⚗️🧪🖥️

I will soon be posting a postdoc position in protein biochemistry/biophyics! Interested candidates are welcome to reach out at luclar@kemi.dtu.dk. Experience in protein expression, purification, and assay development is a must. Structural biology would be great! Please RT :)

Rxn-INSIGHT also has some functions for molecules, but many more for reactions. Functional groups and rings are handled separately here:

github.com/mrodobbe/Rxn...

RNA xkcd.com/3056

BioSB HotTopics Symposium flyer on "Data representation of small molecules and their application" 25-03-2025 from 12:30 to 17:00 in the O2 Arena at VU Amsterdam

I will be playing in the O2 Arena!

Well, I won't be playing, I'll be talking... and no, it's not the one in London but the one in Amsterdam...

But if you're around, it would be cool to meet you there. 😊

www.dtls.nl/data-represe...

Quantitation and Error Measurements in Dose–Response Curves

If you work in drug discovery and you read one thing this weekend, make it this exceptional J Med Chem editorial. Hits on almost every blessed thing I’ve tweetorialized over the last several years.

Quantitation and Error Measurements in Dose–Response Curves

#compchem

Sunday morning, Hamburg Fischmarkt.

Magazin-Cover

Multiresistente Keime: Die Waffen gegen gefährliche Bakterien werden zunehmend stumpf, immer häufiger können lebensbedrohliche Infektionen nicht mehr therapiert werden. Ersatz gibt es bisher kaum. Im neuen Fraunhofer-Magazin stellen wir neue Chancen aus der angewandten Forschung vor: s.fhg.de/P3pj

Want to make beautiful scientific figures? Easy!

The NIH released a library of 2000+ free scientific illustrations called *BioArt*.

Check it out! bioart.niaid.nih.gov

#AcademicSky #PsychSciSky 🧠🟦 🧪

Hey, a few familiar ones on that list. Congrats!

I think, the main reason why the linter complains might be, that "None" should not be used in a truthy comparison, but instead "if compound.synonyms is not None:".

I am now very happy to announce that I have started a new position, at the ScreeningPort group of the Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP) in Hamburg. I am very much looking forward to work with new colleagues on many exciting projects.

After almost 10 years on consecutive temporary contracts, it was time for me to leave the MPI in Dortmund. Thank you to everyone for the really good time.

Fantastic resource for bio icons: NIH Bioart Source

Build figures, presentations, and illustrations with 2,000+ science and medical art visuals. This collection of high-quality, scientifically accurate vectors, #icons, and brushes is freely available within the public domain. bioart.niaid.nih.gov

It's *that* Sunday...

Thank you. This is the content I'm here for.

Cool. See you there.