Looks like electron cryo-microscopy/tomography has finally lost the battle

Thorsten, I am so sorry to read this. Thank you for sharing – it takes real courage. I wish you and your family great strength. Your work has meant a lot to our field and to me personally.

Oops! Public now

Somewhat related: I was looking for a JS library to read MRC files a while ago, but couldn't find one (sorry if I missed it). So you can now “npm install @warpem/mrc-parser”

github.com/warpem/mrc-p...

Euler Hunt Can you find the Euler angles of a cryo-EM projection?

I had Claude make this as a mini-game for Relay's disconnect screen (like Chrome's dinosaur), but then pivoted to stand-alone. In this game, you have to find Euler angles matching the target projection, i.e. cosplay RELION. It can be pretty hard. Works on mobile too! warpem.github.io/euler-hunt/

peon-ping — Stop babysitting your terminal Game character voice lines as notifications for Claude Code, Codex, Cursor, Antigravity & more. Never miss when your AI agent needs you.

Once you install peonping.com, don't forget to mute the volume if you decide to claude something during a meeting

Caps lock button on an Apple keyboard, activated by a cat stepping on it

A cats lock key that lets you quickly disable the keyboard when a cat approaches it would be a lot more useful than the antiquated caps lock

Ahh, that must be the one I heard about!

What is the current resolution record for in situ nucleosomes? The best unofficial result I remember seeing was around 7 Å, but I feel like I've heard a better figure mentioned somewhere already

California is famous for its sunsets, but sunny early mornings are the real magic here

To differentiate well-aligned bots from malicious humans cosplaying as bots

Do we have “I am a robot” CAPTCHAs for Moltbook yet?

Whoa! I lived there for 1.5 years not realizing the danger I was in. At least I'm acutely aware of the coyotes around our place in the North Bay now

I need to know more about the Alameda raccoon

When using vertical tabs in Chrome, the tabs and the new tab button are light-years apart

Super happy to finally see native vertical tabs in Chrome, but why why why is the + button all the way at the bottom? #uxsky

If someone's age is a prime number, are they in their prime?

This exciting new method has a bright future!

LLMs automatically tailor cover letters to job postings now. Certainly useful when it isn't obvious from the CV why someone would fit (e.g. switching fields), but otherwise not a useful indicator anymore

Great CV advice in this thread! I'll also add that for computational scientists, a GitHub/GitLab link is a must. Sure, there are people whose work I know well enough to not care about their repos, but don't bet on that.

Here is the image I recently used to summarize it, but with the hero's identity censored since I imagine he might not like seeing this particular depiction in public 😅

The important thing to understand is that none of this is unique to Russia (although Russia's level of execution here is remarkable). If you feel powerless, depressed and exhausted (or, as a necessary precursor to that, enraged) after reading the news, it's usually by design.

I didn't, I just jumped on the incomplete conclusion. I assume the author lives in an intelligent middle-class bubble, which would be a likely target for “overwhelm into indifference.” But there are so many people outside that bubble, and they all require different approaches.

Different propaganda types for different groups of people: some can be convinced by repeating, others can be made indifferent. Plenty of resources available to do both and then some more.

2026 will bring great tilt series alignments for the ribosome-deficient among us 🎆

Unexpected Cube 😃

Oh, even better: trained from scratch on, and applied to half-maps that were low-pass filtered to 2.5 Å

Those are dependent on low-res information and thus are consistent, but don't carry useful structural information of their own

A denoiser trained w/ n2n isn't required to operate in a sin/cos basis like FT. Whatever the resolution, the denoiser won't apply a hard low-pass filter. There won't be ringing. This added smoothness puts strongly attenuated, yet consistent components beyond nominal resolution

Here is why friends don't let friends calculate FSC on denoised half-maps. I took EMD-17961, denoised the maps using Warp's Noise2Map, and calculated the FSC between various things. With noise gone from the half-maps, their consistency is no longer related to SSNR. Denoised map vs. model still works

Don't get me wrong: the original IsoNet was the coolest thing to happen in cryoET in at least a decade. But after the initial “wow” moment it's time to make this topic more sciency