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Posts by A/Prof Sam Stehbens PhD (She/Her)

Couldn’t agree more 👏

6 days ago 2 0 0 0

Happy to announce that my institution, @irbbarcelona.org, is opening two group leader positions, 1 in chemical biology and 1 in structural biology, to strengthen our expertise in molecular sciences: please spread the word !

1 month ago 15 19 0 0

If you are interested in doing a postdoc of quantitative biology, biological physics or similar areas… we got you covered 😃 👇🏻

4 weeks ago 11 7 0 0
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accurate….. #outlook

4 weeks ago 4 1 1 0
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#Academics: file naming conventions final version-1.dox …..oh wait, final version-1v2…

1 month ago 0 0 0 1
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All the feels tonight for the Australian biomedical research sector #nhmrc

1 month ago 7 3 0 0
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‘Complete joke’: Efforts to reduce funding wait times ends with longer blowout A long campaign to improve Australia’s sclerotic research bureaucracy has culminated in an extraordinary blowout to grant approval times, leaving scientists despondent.

“A complete joke”

After the starting gun fires, Australian researchers have to wait 2–3 years before even starting the race.

Really clear article explaining the impossibly long new time-frames for Australian Research Council grants.

By @liammannix.bsky.social

1 month ago 59 31 3 1

Sounds like a gummy bear company…

1 month ago 1 0 0 0
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Does anyone know of an anti mStayGold antibody that works for immunoblots / IP? Anyone tried the one from HUABIO (not even sure that’s a real company)? Thanks!

1 month ago 1 10 2 0
A man standing up in a crowded room of people sitting. He is dressed in workman's clothes and has his head raised as if speaking up when not necessarily belonging there.

A man standing up in a crowded room of people sitting. He is dressed in workman's clothes and has his head raised as if speaking up when not necessarily belonging there.

We are a rich enough country to be funding 37% of all basic research proposals, not just considering "the best" 37% and then maybe only funding 12% in the end.

1 month ago 1015 165 32 1
Screenshot of LinkedIn post from ARC saying that DP27 EOI outcomes will be released on RMS on the 26th Feb 2026.

Screenshot of LinkedIn post from ARC saying that DP27 EOI outcomes will be released on RMS on the 26th Feb 2026.

The ARC have said (on LinkedIn) they will release outcomes for Discovery Projects Expressions of Interest (2027) tomorrow👇

1 month ago 36 21 1 4
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Grant delays feared as ARC ramps up ‘due diligence’ Researchers brace for renewed funding uncertainty as security checks prove ‘more time-consuming than imagined’

The massive delays ARC announced for all grant schemes – with longer processing times & 3-month announcement windows – were examined in Senate Estimates recently.

Here’s John Ross reporting on it, & the confusing Estimates hearing, for Times Higher Ed👇

www.timeshighereducation.com/news/grant-d...

1 month ago 17 6 1 0

It was a really great meeting- I learnt a lot. Brought together scientists from vastly different areas in such a complementary way. I look forward to seeing it continue.

1 month ago 2 0 0 0
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Blood vessel development and lumenization in a zebrafish embryo. Credit to Dr. Kazuhide Shaun Okuda @latrobeuni.bsky.social. #ZebrafishZunday 🧪

1 month ago 69 19 2 0

Airports have no time zones. Therefore you are correct- never ‘too early’ 😆

1 month ago 1 0 0 0
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a blue dog and an orange dog are standing next to each other and waving ALT: a blue dog and an orange dog are standing next to each other and waving

Michael Krieg, Verena Ruprecht, @felixmendu.bsky.social & Giovanna Petrillo. You have set the bar very high for any Australian conference I help organise 😆 you were wonderful hosts.

1 month ago 1 0 1 0
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Home from a great #EMBO workshop in Barcelona. Intracellular mechanics & organelle Mechanobiology was such a fun topic! @christanny.bsky.social made sure I didn’t get lost. It was great to catch up with @katemiro.bsky.social 1st time in almost 10yrs!!. Thank you to the hosts.. (continued) 1/2

1 month ago 17 3 1 0

Do you want to pursue your ideas in computational biology independently, running your group in @embl.org‘s uniquely collaborative environment, beside world’s most comprehensive biomolecular data resources @ebi.embl.org in Genome Campus next to @sangerinstitute.bsky.social?
Apply to join us & share 🙏

2 months ago 15 15 1 0
The ever-changing communication of scientific discovery Nature Biomedical Engineering - We take a look at how scientific articles have evolved over time and envision possible changes to how research findings are communicated in the age of digital media...

"authors also express frustration at the amount of work expected for a single publishable unit, a concern we
share (while humbly noting that it may not be
held by the same authors when they serve as
reviewers of other work)" <-THAT www.nature.com/articles/s41... ht @ritastrack.bsky.social

2 months ago 28 10 1 0
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I’m likely shouting into the echo chamber here but 👉 #DiscoveryScience is so important.

2 months ago 4 2 0 2
Septins buffer actomyosin forces to protect the nucleus from genotoxic mechanical stress Invasively migrating cells thread their nucleus through confined interstitial spaces. How cells protect the nucleus from intracellular forces is poorly understood. Here, we show that the septin cytoskeleton buffers the actomyosin forces that power nuclear movement. Septin filaments comprising SEPT9, a septin amplified in breast cancer, align with perinuclear actomyosin cables which exhibit higher tensile stress during 3D confined migration through narrower pores. SEPT9 depletion amplifies actin stress during confined migration and after myosin II hyper-activation in non-migrating cells causing actin and nuclear envelope ruptures. Following confined migration, DNA breaks, nuclear blebs, micronuclei and cell death increase in SEPT9-depleted cells, phenotypes rescued by the oncogenic SEPT9 isoform 1. Clinicogenomic data reveal that SEPT9 amplification associates with lower genomic alteration in aggressive breast tumors and higher patient mortality. We propose that septins are a mechanoprotective element of the cytoskeleton, and SEPT9 amplification enhances tumor cell survival by preventing nuclear damage. ### Competing Interest Statement The authors have no competing interests. National Institute of General Medical Sciences, https://ror.org/04q48ey07, 2 R35GM136337-07 National Institute on Aging, https://ror.org/049v75w11, 4 R01AG068908-03

Septins buffer actomyosin forces to protect the nucleus from genotoxic mechanical stress www.biorxiv.org/content/10.6...

2 months ago 10 3 0 0

#NARF is on bluesky! 👉 if you’ve held a fellowship in the last 10 years, you should join.

2 months ago 1 2 0 0
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I came here looking 👀 for a cat. I heard there might be a cat in this tutorial? 😆

2 months ago 2 0 0 0

So excited to share the preprint with the bulk of my PhD work in the Beach @myosincity.bsky.social and Oakes @pwoakes.bsky.social Labs at Loyola University Chicago! We investigate the structure, recruitment, and function of septin networks around the nucleus. A thread:
doi.org/10.64898/202...

2 months ago 28 15 2 2
Figure 1. Spectraplakins, including MACF1, are large cytoskeletal scaffold proteins that crosslink actin filaments and microtubules to coordinate cellular architecture, polarity, and intracellular organization. This group of proteins has a modular architecture consisting of an N-terminal actin-binding domain, central spectrin-repeat rod regions, and C-terminal microtubule-binding motifs (left). These complex proteins have various functions in neurons, including regulation of neurite outgrowth, axon guidance, synapse organization, and intracellular trafficking (right). Figures from Cusseddu et al. (2021) under a Creative Commons CC BY license.

Figure 1. Spectraplakins, including MACF1, are large cytoskeletal scaffold proteins that crosslink actin filaments and microtubules to coordinate cellular architecture, polarity, and intracellular organization. This group of proteins has a modular architecture consisting of an N-terminal actin-binding domain, central spectrin-repeat rod regions, and C-terminal microtubule-binding motifs (left). These complex proteins have various functions in neurons, including regulation of neurite outgrowth, axon guidance, synapse organization, and intracellular trafficking (right). Figures from Cusseddu et al. (2021) under a Creative Commons CC BY license.

The MACF1 puzzle: when a cytoskeletal giant causes multiple brain disorders | Beyond the Ion Channel

...we just published our new post on why interpreting MACF1 variants is so difficult, highlighting how this massive spectraplakin gene can produce distinct neurodevelopmental phenotypes.

2 months ago 1 2 0 1
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🔬 Postdoc position – Infection Biology & Cryo-ET (Zurich) 🇨🇭
We are looking for a motivated Postdoc to join our interdisciplinary team.
📩 Interested? Check out the job advert:
www.imm.uzh.ch/dam/jcr:cb17...

👉 More info on the lab: www.weiss-laboratory.com
Please share with interested colleagues!

3 months ago 29 23 0 3
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Interested in cell-cell communication and microscopy? We are searching for a motivated postdoctoral researcher to join Münster! Please Apply! @uni-muenster.de

3 months ago 22 24 1 0

New from the lab: we report the development of our glutamine biosensor, iGlo, and use iGlo to study spatial and temporal dynamics of glutamine metabolism. Plasmids are being deposited with Addgene!

3 months ago 7 3 0 0

I purchased a kindle for my daughter- she asked for one after watching me read mine. I too worry we’ll lose reading as a hobby. 😞 too much quick fix dopamine in reels & tiktoks

3 months ago 2 0 1 0
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Not my cat but very much my cat’s vibe. #CatsOfAcademia

3 months ago 3 0 0 0