I think the skeet that Mike quote-skeeted is incredibly misleading and should be corrected

Agreed—migraine mechanism likely to be orthogonal to the headache mechanisms that would benefit from IV fluids

Isn't this 3 unrelated families?

Editors, save yourselves and the rest of us time: only send something out for add'l rounds of review if addressing reviewer comments is material to the decision. If a reviewer tells you it's just not important science, you should decide after the first round whether you agree or disagree.

One thing that drives me nuts in peer review is when there are concerns about a manuscript's fundamental significance or fit for journal and it gets pushed on to a 2nd or 3rd round of review before rejection. This is not something you can fix in an additional round of review!

It is totally a disaster unless you use one of the helpful scripts people have uploaded. There are a few nice ones on GitHub!

I interpret it as "85% of the people employed in research jobs at t=0 had research jobs two years before, and there was no significant difference in genders."
If you had matched non-parent controls, you could see if there is a "future parenthood" penalty there, but the null is they also would be 85%

Resolved: that the university buy a Nion for classroom instruction

If you do later break your oath, I doubt you'll hear any complaining from the fans!

This is interesting...our experience is we get devitrification under similar thermal annealing cycles (although we used buffered protein solutions instead of whole cells, so one possible difference is the intrinsic cryoprotectant ability of cells)

Is this an Arctis?

Theoretically a superior approach to blotting, but in practice, we have yet to see a device that is suitable for replacing our plungers for daily experiments! So I contend that the field remains open, as alternative approaches might end up working better in practice

I suspect most cryo-EM experts leave unsaid that we all think filter paper blot-based plunge freezing will be obsolete in 10 years but we have no idea what technique will obsolete it.

the posting is live jobs.rutgers.edu/postings/270...

I think we can do it in about 32 months?

It's time for me to hire someone so we can determine the origin of life in the universe together. Is that of interest to anybody

taken for granted. My hope is that you continue to have these fonts of joy and meaning all the days of your life. And every line of code you write with your eye tracker is a contribution to humankind's struggle to overcome disease and suffering.

I am glad I stumbled on your thread. Yours is a name I knew only from the impact your work has had on science, and I am grateful for your sharing. I recently lost a friend who passed away 16 years after his ALS diagnosis. Bathing him and helping him eat, showed me there were so many things I had

This unforgettable line from a papillomavirus talk at ASV many years ago remains lodged in my brain:

"When two college students come into contact, one never knows which epithelia will be implicated."

we’re going to destroy humanity,” and now he is allegedly going to get handed a $10 billion stake in OpenAI because he’s going around saying “oh no, nobody should give me equity, that’s ludicrous.” '
Good to see Anthropic joining the business negging arena ;)

Matt Levine calls this "business negging."
'Nobody in history has ever been better at, like, business negging than Sam Altman. He got OpenAI to a $150 billion valuation in part by going around saying “oh no, nobody should allow us to build our product,

We had a cure for hemophilia A, until today.
This feels so strange to say, or to contemplate: that we can un-cure a disease because of collective disinterest.

I think I remember mine updating to Council Review Completed for a while before anything concrete actually happened. In a normal year you will get Council Review Completed after review for a long time before you get NoA or no NoA because IC hasn't processed the award or maybe is waiting for funds

1. Greenland has universal healthcare
2. If we take country, we get whatever that country has
3. Therefore, if we take Greenland, we get universal healthcare
I believe that was the train of logic supporting the Venezuela incursion, in any case.

dicing up some grubs for old-fashioned diagnostic virology

At what resolution in cryo-EM do you see clear holes in aromatics? I see in some X-ray crystallography literature people are saying 1.6Å, but in cryo they seem quite visible at lower resolutions than this.

Employee directory lists them as "non-government," so they may not actually be "working for" NIH OD.

life achievement: replaced my chainsaw chain for the first time

The description of this system (and even many of the specific details) was terrifyingly familiar to me in NJ. I traipse through too many stories like this as a co-director of our local interfaith shelter. The enormity of the "wrongness" of it is difficult to sit with.

I live near Great Swamp but my first visit was underwhelming compared to nearby spots. Any recommendations of how to best experience it?