I absolutely think platelets could be a powerful 'liquid biopsy' source for AML/CML as well - based on our prior published data showing a trend (⬆️ or ⬇️) in platelet gene expression across the chronic MPN subtypes - ET/PV to MF - and therefore, potentially to chronic leukemias. Thank you for the qn!

Using matched WBC and platelet RNA-seq from MPN patients, we identify myelofibrosis-associated transcriptomic signatures specifically enriched in platelets. Multinomial LASSO modeling highlights platelet-derived gene expression as a dominant and predictive biomarker of myelofibrosis, outperforming clinical parameters and WBC signatures.

Happy to share a preprint here (bit.ly/4c6yECo) - years in the making that asks a deceptively simple question: when it comes to reading #MPN disease from peripheral blood, do #platelets or white blood cells tell us more?

Details:
bit.ly/4caanLT

Thanks for your read!
#MPN #platelet #WBC #RNAseq

USA - exponential growth of the top 1% wealth vs flat line for bottom 50. Nerds want to do some curve fitting to figure out this growth rate constant - RC. Rampant Capitalism

Can anyone do some curve fitting to find the exponential we need to fit to find the formula for the rise of the US 1%’s wealth and then maybe their delta over the bottom 50%?

I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.

So good to see you in our neck of the woods! Oddly enough, not the best week weatherwise it appears to come to the Bay Area :( Hope you had a good time nevertheless.

National Library of Medicine and 24 other accounts | 11511545 Apportionment file 11511545 (National Library of Medicine and 24 other accounts) retrieved from OMB public records

OMB has posted the full-year apportionments for NIH.

openomb.org/file/11511545

I believe this means that NIH now has the spending authority to fund grants!

There may be nuances and I will be tracking these as best I can.

Action Item...Action Item...Action Item

Time to comment on the Framework for the NIH-Wide Strategic Plan

grants.nih.gov/grants/guide...

Comments due by May 16, 2026

we are losing so much talent, progress, and hope for no good reason www.vox.com/future-perfe...

Current NIH leadership want you to think they are using rigorous, consistent & scientific processes to screen studies to align them with agency priorities.

But the process that they have put down on paper is a sham.

It’s important to know NIH is not following its own guidance. Here’s why:

🧵1/

Pls re-post: My department @oxfordbiochemistry.bsky.social are recruiting for several new faculty positions (links below). Broad search in molecular biology/biochemistry, across prokaryotes and eukaryotes. Interested in understanding life at the molecular level, this job might be for you!
1/n

WHERE OH WHERE would we be without "deranged activists"!!! (ha ha i see now trademarked 🤣)

a cartoon cat with the words now im concerned on a number of levels ALT: a cartoon cat with the words now im concerned on a number of levels

All in all, this update reveals a number of issues to be concerned about:

(1) Slow pace of grant making, particularly for new and competitive renewal grants

(2) OMB apportionment delays as a possible cause

(3) Slow pace of institutional training grants

(4) Increased use of multiyear funding

9/9

Made a short video as a response. 3 questions remain for me.

1) What is the definition of a "DEl activity," and how is it being communicated to NIH staff so they can determine whether a grant qualifies?

(Continued below)

Thanks, @maxkozlov.bsky.social .

I will go further. This deranged activist was also known for criticizing NIH Director Francis Collins during the Obama administration when he felt that Collins was making decisions not aligned with the best interests of the NIH.

www.science.org/doi/10.1126/...

1/3

White House stalls release of approved US science budgets The US Congress rejected sweeping cuts to science agencies. But the NIH, the NSF and NASA have had their spending slowed.

Congress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers.

The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇

these $$$ could have funded biomedical research, including some of the 1000+ NIH grant proposals that were found to be highly meritorious in peer review

the payoff for that investment would be immediate ($2.63 per USD) and sustained (education, training, discoveries, careers)

House passes budget bill to end partial government shutdown The measure funds most of the federal government through Sept. 30, while providing the Department of Homeland Security with short-term funding for two weeks. Lawmakers will return to negotiate potenti...

NEW: The House passed a bill to end the partial government shutdown Tuesday afternoon, cleared by a bipartisan vote under the insistence of President Donald Trump. https://to.pbs.org/4qgEm9M

Update from Catie Edmondson

Update:

"Senate Democrats have struck a deal with Republicans and the White House to pass five [bills and] a stopgap measure to fund the DHS for two weeks while they continue negotiating guardrails to rein in immigration agents."

#ICE #DHS

www.nytimes.com/live/2026/01...

Larry Summers is not only pals with Epstein but also can't write a coherent email YouTube video by Dr. Arghavan Salles, MD, PhD

Friends, it’s time to let that imposter syndrome go. Former Harvard president and former secretary of the treasury Larry Summers can’t even write a coherent email. Plus, his bestie was a pedophile sex trafficker. And the sex trafficker’s other bestie is president.

You deserve that promotion!

NIH Study Section Watch Day 1: No communication about rescheduling.

long time no see, Svasti! great to connect here.

'Born Poor’ in America, They're Now Fighting to Shake Poverty’s Lingering Impact | FRONTLINE Watch the prologue from "Born Poor" — a documentary made over 14 years that follows kids in three families who try to overcome poverty from childhood through the teen years to young adulthood.

Odd or jarring as it might be for some in my professional community, this brilliant @pbs.org documntary echoes aspects of my bkgrnd.

Science was the path for me & that was entirely fortuitous.

Hope many of you find a chance to watch this & think on how (& to whom) we open doors of opportunity!

What if NIH had been 40% smaller? Replaying history with less NIH funding shows widespread impacts on drug-linked research

This may be the most important paper ever published about NIH funded research.

www.science.org/doi/10.1126/...

NIH's updated multi-year payout policy (funding all years of a grant upfront vs. annually) could dramatically reduce new R01s available. While total awards are "catching up," the impact on new investigators remains concerning. With budget negotiations underway, now's the time to contact your reps!

I am leading a workshop tonight for students in my department on how to apply for the NSF GRFP, but have not received answers from NSF to my questions about whether they are still funding applications in neuroscience and cognitive science, etc. If anyone has info please let me know.
(continued)

We Are Here | Driving Health, Opportunity & Stronger Communities YouTube video by Big Ten Conference

This ad for us scientists and educators from the Big Ten Academic Alliance is nicely done!

Share widely please - not just in reposts but also in speaking with members of your community.

www.youtube.com/watch?v=sWmc...

😀😍 How are we middle class Indians if we dont get the Costco cake?!

Congrats to the Maliks!

@jengreitz.bsky.social l & my lab want to co-hire a computational biologist/biostatistician with project management expertise to help map the regulatory code of the human genome and discover genetic mechanisms of disease.

Details below
careersearch.stanford.edu/jobs/computa...

Plz RT

Few examples:

1) understand where the payline is and what score compression looks like. I suspect a 1 will be required. Maybe 1 or 2 apps will be funded per SS.
2) be kind to ESI/NI and other discriminated groups
3) maybe drop the whole "this is an A1 but I'm going to pretend it's not" approach.