My choice this week in @science.org
RCC1 depletion drives protein transport defects and rupture in micronuclei
doi.org/10.1083/jcb....

Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular organization. The plasmid-encoded ParMRC system forms actin-like filaments that segregate low–copy number plasmids. In m...

Out now in @science.org
Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape | Science www.science.org/doi/10.1126/...

Stem cell control in the lung by an autocrine injury-activated Igf complex Stem cells proliferate after injury to repair damaged tissue, and chronic injury can promote cancer. However, the injury-activated signals and regulatory mechanisms, and their relationship to cancer, ...

Just published in @science.org
Stem cell control in the lung by an autocrine injury-activated Igf complex | Science www.science.org/doi/10.1126/...

Please join us online tomorrow! @science.org and Westlake online symposium - Translational control by ribosome heterogeneity

Join me this time next week for the
@science.org and Westlake Online Symposium
Translational control by ribosome heterogeneity
Speakers: Amy Si-Ying Lee, Julie Aspden, Maria Barna
Date & Time Apr 15, 2026 8 pm Beijing; 1 pm UK; 8 am EST
en.westlake.edu.cn/academics/Sc...
Free registration

Awakening latent regeneration in mammals | Science www.science.org/doi/10.1126/...

Hyaluronic acid and tissue mechanics orchestrate mammalian digit tip regeneration | Science www.science.org/doi/10.1126/...

Check out 2 papers and a related Perspective on tissue regeneration in @science.org this week
Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration | Science www.science.org/doi/10.1126/...

Join me this time next week for the
@science.org and Westlake Online Symposium
Translational control by ribosome heterogeneity
Speakers: Amy Si-Ying Lee, Julie Aspden, Maria Barna
Date & Time Apr 15, 2026 8 pm Beijing; 1 pm UK; 8 am EST
en.westlake.edu.cn/academics/Sc...
Free registration

My choice in @science.org whilst I was on vacation a week or so ago
DOI: 10.1016/j.cell.2025.12.007
Multimodal supramolecular targeting chimeras enable spatiotemporally resolved protein degradation in vivo

Mitochondrial genomes on a string of pearls Transient membrane constrictions, or “pearling,” underlie the regular spacing of mitochondrial genomes

and its related Perspective also in @science.org
Mitochondrial genomes on a string of pearls | Science www.science.org/doi/10.1126/...

Pearling drives mitochondrial DNA nucleoid distribution The distribution of mitochondrial DNA–containing nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their regula...

Out now in @science.org
Pearling drives mitochondrial DNA nucleoid distribution | Science www.science.org/doi/10.1126/...

Harnessing viral strategies to reverse cognitive dysfunction through the integrated stress response The integrated stress response (ISR) is essential for cellular homeostasis and cognitive function. We investigated how persistent ISR activation affects cognitive performance by studying the PPP1R15BR...

Out now in @science.org
Harnessing viral strategies to reverse cognitive dysfunction through the integrated stress response | Science www.science.org/doi/10.1126/...

Systems-level organization of extracellular proteostasis One defining feature of complex organisms is the ability to maintain protein homeostasis beyond cellular boundaries. We review how extracellular proteostasis is organized as a hierarchical network spa...

Check out this Review published in @science.org whilst I was on vacation
Systems-level organization of extracellular proteostasis | Science www.science.org/doi/10.1126/...

Host-derived nitrate fuels indole production by Escherichia coli to drive chronic kidney disease progression Chronic kidney disease (CKD) is linked to an elevated fecal abundance of Enterobacteriaceae, but the ecological drivers of this shift and its impact on disease progression remain unclear. The uremic t...

Out now in @science.org
Host-derived nitrate fuels indole production by Escherichia coli to drive chronic kidney disease progression | Science www.science.org/doi/10.1126/...

WEDNESDAY 18 MARCH 2026 - NOON UK, 8PM China, 8AM EDT

WEDNESDAY 18 MARCH 2026 - NOON UK, 8PM China, 8AM EDT

WEDNESDAY 18 MARCH 2026 - NOON UK, 8PM China, 8AM EDT

WEDNESDAY 18 MARCH 2026 - NOON UK, 8PM China, 8AM EDT

WEDNESDAY 18 MARCH 2026 - NOON UK, 8PM China, 8AM EDT

@science.org
Registration Link for Audiences:
us02web.zoom.us/webinar/regi...

Also see its associated Perspective in @science.org
Extending the reach of a classic oncogene
Exocytosis exposes Src at the outer surface of cancer cells, poised for therapeutic targeting
www.science.org/doi/10.1126/...

Autophagolysosomal exocytosis inverts Src kinase onto the cell surface in cancer Overexpression of the proto-oncogene Src is common to a wide variety of cancers. In this work, we found that Src is noncanonically translocated and inverted onto the cell surface in cancer, both in vi...

Just published in @science.org
Autophagolysosomal exocytosis inverts Src kinase onto the cell surface in cancer | Science www.science.org/doi/10.1126/...

Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...

Just published in @science.org
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | Science www.science.org/doi/10.1126/...

Rethinking Cancer Metabolism - Westlake x Science\/AAAS Joint Online Symposium #01 (2026) Altered metabolism is a hallmark of cancer: malignant cells re-engineer nutrient acquisition and utilization to fuel unchecked growth and survival. Beyond functioning as a simple energy powerhouse, metabolic rewiring reshapes virtually every layer of cell regulation, from chromatin architecture a...

Join Matthew Vander Heiden (MIT), Sarah-Maria Fendt (VIB), Ralph J. DeBerardinis (UTSW), and me (Deputy Editor @science.org) online Wed March 18 to hear about the influence of metabolism on cancer progression.
Free registration below.
lifesciences.westlake.edu.cn/media/events...

Independent nuclear and organellar mechanisms determine apicoplast fate in malaria parasites

My choice this week in @science.org
@florentin-lab.bsky.social
doi.org/10.1083/jcb....

Termination of the integrated stress response Stress responses enable cells to detect, adapt to, and survive challenges. The benefit of these signaling pathways depends on their reversibility. The integrated stress response (ISR) is elicited by p...

Final version out now in @science.org
Termination of the integrated stress response | Science www.science.org/doi/10.1126/...

Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes Cells down-regulate protein synthesis when stressed to conserve energy and shift resources toward repair. We found that in some mammalian cells, including neurons, stress also resulted in the formatio...

Out now in @science.org
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science www.science.org/doi/10.1126/...

Bacteria gain a firm hold in the airways Pathogenic Bordetella avoid clearance from airways by hanging on to microtubules of ciliated cells

www.science.org/doi/10.1126/...