The immune system is dangerous, usually more to pathogens than to you. But only because it’s so tightly controlled.

Activating a T cell can have horrific consequences. You really don’t want to trigger one unless it’s absolutely necessary. You need to be sure. How?
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T follicular helper and regulatory cells in human lymphoid tissue mature distinctly, defined by PD-1 and ICOS protein levels @lgraca.bsky.social
www.science.org/doi/10.1126/...

A single shot of a flu drug could outperform vaccines—and protect for an entire season One injection of a long-lasting drug showed up to 76% efficacy in a large trial

In some good news- this is an interesting idea. Lencapavirification (yes I made that term up) of flu antivirals:

www.science.org/content/arti...

Details on the drug here.
www.nature.com/articles/s41...

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