New paper from @zhixingchen2.bsky.social's lab!
It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!
www.nature.com/articles/s41...
Congrats Donita!! So well deserved!
Feeling mitochondrially challenged lately?
Here are two classic reviews on #mitochondria that should help.
www.cell.com/current-biol...
www.cell.com/current-biol...
Thrilled to share a new preprint! 📝 🎉 Lewis lab PhD student Casadora wondered: Do mtDNA synthesis and lipid droplet biogenesis co-occur at the same membrane contact sites? Or can we discern distinct ER-mito contact classes? Evidence suggests the latter, relevant in overnutrition!
do you ever stare at the ceiling and think about how the worldwide scientific establishment did the impossible and created a COVID vaccine in under a year and the response of the general public has been to go on an unstoppable rampage to destroy science and scientists
A must-read for anyone in mitochondria research!
Journal of Cell Science has released a Special Issue on the Cell Biology of Mitochondria - articles, reviews, and expert insights covering dynamics, disease, and more!
View our summary mitoworld.org/special-issu...
Banner day for our grad students at the always amazing Dept. of Microbiology, Immunology & Cancer Biology Retreat. Congrats to Daniel and Salma for “lightning talk” and “poster” awards! Great science all around!!
🔥Smoking hot new paper and tweetorial from @djcalebc.bsky.social (collab with Chinnaiyan Lab)! 🔥
We are over the moon about this new work and its therapeutic implications for pancreatic cancer. Please have a read and share your thoughts/feedback! 🙏🏼
I'm thrilled to share that our story is now out in Science Advances! 🎉 We use quantitative imaging to map the mito central dogma, define translation hubs in the mitochondrial matrix, and show that they're replaced by Mitochondrial Stress Bodies (MSB) when mtRNA processing is perturbed 1/4
Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.
This one hurts a lot. Richard is a great scientist. His elegant work inspired me to get into mitochondrial biology and he went out of his way to help me establish myself in the field. So sad for our whole community.
Dr. Richard Youle was fired today. He is an eminent scientist who has done important work on brain diseases like dementia and Parkinson’s.
Musk and Trump are stopping NIH research into cures, for diseases from cancer to Alzheimer’s. Americans did not vote for this.
🧪 Scientists have created the first map of mitochondria throughout the entire brain
https://go.nature.com/42j9YCV
In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.
Learn more in this week's issue: scim.ag/3FA3Ygq
Abstracts are due TOMORROW! Please share!
mtDNA goes places, and sometimes nucleoids end up in stressful situations. Our next speaker @lauraenewmanphd.bsky.social
is keeping an eye (or two) on this, and will tell us all about it.
This week, usual time and place.
1/I am delighted to share a new Cancer Discovery paper about metabolism and clinical outcomes in patients with non-small cell lung cancer (NSCLC). From Ling Cai and Brandon
@faubert.bsky.social, @cri-utsw.bsky.social and UT Southwestern McDermott Center.
My editorial on the indirect cuts. This is an opportunity for campuses to come together to make the case for higher education. Leaders need to step up and ask for support and lead. www.science.org/doi/10.1126/...
Delighted to share our latest paper describing a method to read the levels of hundreds of metabolites or drugs in parallel using DNA sequencing. This method, which we call ‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection:
rdcu.be/d8xLv (1/6)
Proud to see this #relentlessdiscovery, by @rjdlab.bsky.social & colleages, visualized about how mitochondrial ETC is much more active in tumors that have metastasized than in tumors still growing in the kidney. Watch ⬇️ www.youtube.com/watch?v=-pmz... or read more ➡️ cri.utsw.edu/kidney-cance... 🧪
(A) Oxidative mitochondria, in red, retain cristae to house the electron transport chain, comprising complexes CI, CII, CIII, CIV, and CV. Glutamine metabolism in the oxidative tricarboxylic acid (TCA) cycle fuels ATP synthesis. Oxidative mitochondria can be identified by the retention of CV expression. Reductive mitochondria, in blue, lose cristae and use reducing potential to drive reductive ornithine and proline biosynthesis from glutamine. Reductive mitochondria distinctly present with pyrroline-5-carboxylase synthase (P5CS) filaments. (B) Reductive mitochondria in which P5CS has been oligomerized into filaments are sequestered via mitochondrial fission, a process that can be mediated by dynamin-like protein 1 (DRP1). Mitochondrial fusion sequesters oxidative mitochondria. This process can be driven by mitofusin 1 and 2 (MFN1/2).
ONLINE NOW! Subcellular mitochondrial heterogeneity enables opposing metabolic demands, by @brandontwchen.bsky.social, Yatrik Shah and @lyssiotislab.bsky.social, discussing the recent work by @keunwooryu.bsky.social et al.
Read it for free until March 19th at:
authors.elsevier.com/a/1kWLq3jDgW...
