Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease - Nature Mapping of neurogenesis in human hippocampi across ages and different cognitive abilities using multiomic single-cell sequencing reveals distinct signatures between cognitive preservation and decline.

New @nature.com
The brains of Super Agers produce more neurons than people some 50 years younger, a neurogenesis resilient signature linked to exceptional cognitive health and memory skills
nature.com/articles/s41...

Committee Releases Conferenced Defense, Homeland Security, Labor, Health and Human Services, Education, and Related Agencies, and Transportation, Housing and Urban Development, and Related Agencies Bi... United States Senate Committee on Appropriations

The conference (agreement between House and Senate) appropriations bill that includes HHS and NIH was released this morning.

www.appropriations.senate.gov/news/majorit...

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Interested in stable isotope infusions but daunted by jugular catheter surgery? New from postdoc @kimyumi0201.bsky.social: our simple tail vein catheter method enables anesthesia-free infusions in awake, freely moving mice. 🧵

After NIH grant cuts, breast cancer research at Harvard slowed, and lab workers left Amid NIH funding delays, reversals and uncertainty, a scientist at Harvard who studies breast cancer has lost one-third of her lab employees and wonders if she can continue her research experiments.

Amid NIH funding delays, reversals and uncertainty, a scientist at Harvard who studies breast cancer has lost one-third of her lab employees and wonders if she can continue her research experiments. n.pr/4a4N3zD

A few more photos of our lab members since Bluesky has photo limits 🙃

Had a lovely time talking science with our peers at #MidwestMetabolism - until next year!! @palpurab.bsky.social @vipinrawat482.bsky.social @meteozgurses.bsky.social

If you’re at the Midwest Metabolism Meeting, make sure you stop by our posters! We have 6 lab members presenting today @meteozgurses.bsky.social @vipinrawat482.bsky.social @palpurab.bsky.social @juliannasupplee.bsky.social @linalietuv.bsky.social

Excited to share our work @nature.com! Postdoc @mariopalma.bsky.social, with major contributions from @retickerflynn.bsky.social and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression. #TeamFSP1

www.nature.com/articles/s41...

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…

Excited to share our latest work out today in @cp-molcell.bsky.social, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo! www.sciencedirect.com/science/arti...
!

Working on some very important, very serious experimental procedures…

Congratulations!

@thermofishersci.bsky.social vendor show today 🤪 can you guess who unwillingly stood for the picture????

Latest lab photo from celebrating Dr. Coloff’s birthday earlier this month!!!! 🥳

Congrats to @meteozgurses.bsky.social for being selected to present his work at Chicago Mass Spec Day last month!!

🤩🤩🤩 @palpurab.bsky.social

Ceramide-induced Endoplasmic Reticulum Stress as a Targetable Vulnerability in Endocrine Therapy-Resistant Breast Cancer www.biorxiv.org/content/10.1101/2025.08....

The Hormone Dependent Cancer Gordon Research Conference got a sneak peak at Purab’s new work before it hits the journals - watch this space, publication dropping soon!!!! 👀 @palpurab.bsky.social

Even MORE exciting Coloff lab news!!! 🥳 after graduating with her PhD from Penn, @juliannasupplee.bsky.social has moved to Chicago to continue her work in cancer lipid metabolism with us as a postdoc!!! Welcome Julianna!!! 🤩

Join us in at Moffitt! The Metabolism Program is recruiting at the Assistant Member (Assistant Professor) level. Review of applications starts September 1st. Please share! Details here: moffitt-cancer-center-careers.hctsportals.com/jobs/1883440...

We also have to give a shoutout to @linalietuv.bsky.social for completing her preliminary exam!! She will now enter the next phase of her program: PhD candidacy 😱

EXCITING COLOFF LAB NEWS: Philippa successfully defended her thesis, “Serine Starvation Modulates mRNA Splicing Through Depletion of SR Proteins,” last month and is officially Dr. Burns!!! Congratulations Philippa!! 🍾

We had the pleasure of hosting Christian Guerrero, a high school student part of @uicancercenter.bsky.social CHESS program, for several weeks this summer. Thank you Christian for your curiosity and hard work, and we can’t wait to see what you do in your future!!

Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.

Proudly presenting Simon’s @simonsterson.bsky.social‬ paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8

From Nobel prize winning cancer researcher Bill Kaelin
Killing the Science Golden Goose - The American Journal of Medicine www.amjmed.com/article/S000...

Congrats to Rushika and Gilles on this really cool work!

05.02.2025 MEDIA ADVISORY: Senate HELP Committee to Hold Hearing with Secretary Kennedy on HHS Budget WASHINGTON – On Wednesday, May 14, the Senate Health, Education, Labor, and Pensions (HELP) Committee will hold a hearing with U.S. Department of Health and Human Services (HHS) Secretary Robert F. Kennedy Jr. to discuss President Trump's proposed HHS budget for fiscal year 2026. This is the first time in at least two decades that the HHS Secretary is testifying on a presidential budget before the HELP Committee. Agenda: Hearing on Fiscal Year 2026 Department of Health and Human Services Budget; Date: Wednesday, May 14, 2025 Time: 1:00 PM ET/ 12:00 PM CT Location: 430 Dirksen Senate Office Building Witnesses: Robert F. Kennedy Jr., Secretary, Department of Health and Human Services

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PLEASE READ, LIKE, REPOST this "1/3" post

There is a Senate Hearing May 14th with RFK Jr to discuss Trump's proposed HHS budget. Please find call/email the members of the committee every day until then (I have compiled contact info for the members in post 2/3)

Coloff lab 🤝 AACR

Last but not least, Mete will be presenting his work at this afternoon’s poster presentation as well. Make sure to check him out!! @meteozgurses.bsky.social

Loooooove single cell RNAseq???? So does Lana! Come talk with her at her poster in the afternoon session #AACR25

Make sure to stop by our resident ceramide nerd’s poster tomorrow between 9-12!