β-hydroxybutyrate enhances the metabolic fitness of CAR T cells in cancer β-hydroxybutyrate (BHB), the ketone body associated with a ketogenic diet, metabolically reprograms and fuels CAR T cells to achieve proliferation, cytokine production, and superior tumor control. The...

β-hydroxybutyrate enhances the metabolic fitness of CAR T cells in cancer: Cell www.cell.com/cell/fulltex...

An amazing meeting for Immunometabolism. Meet our welcoming and inclusive network of researchers. Submit your abstract to present your work! ECRs - we have a Bright Sparks session!!

It became the first nation 100% powered by solar energy — Now climate change threatens its survival this very century One country in particular became the first nation to be 100% powered by solar energy, but now, climate change threatens its survival in this century.

REMINDER: the countries that are contributing the least to climate change are feeling the worst of its affects. #Tokelau #SouthPacific #ClimateActionNow

energiesmedia.com/the-first-na...

Genetic delivery of designed protein nanoparticles displaying the SARS-CoV-2 RBD elicits potent neutralizing antibody and CD8 T cell responses
www.science.org/doi/10.1126/...

To celebrate #BiologyWeek, let's talk about how vaccines work!

See our “How do vaccines work?” infographic below 👇 and learn more in the Vaccines & Therapeutics section of our BiteSized #Immunology resource: https://bit.ly/482sVND

Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells Nature Immunology - Sinclair et al. combine quantitative proteomics and an autophagy flux reporter to map autophagy substrates and triggers during CD8 T cell differentiation. Proteins...

In case you missed it….great study from @lindavsinclair.bsky.social and Doreen Cantrell.

Autophagy and how it shapes CD8 T cell responses

-Differentially pruning naive and effector T cell proteomes
-Dynamically repressed by antigen receptors and inflammatory cytokines

rdcu.be/eJBFA

CAR-T cells containing CD28 versus 4-1BB co-stimulatory domains show distinct metabolic profiles in patients Cook et al. investigate the metabolic profile of DLBCL patient-derived CAR-T cells ex vivo. Comparing Axi-cel (CD28-co-stimulated) and Tisa-cel (4-1BB-co-stimulated) products, they find divergent meta...

Very excited to share our new study comparing the metabolic profile of patient-derived CAR-T cells ex vivo.

CAR-T cells containing CD28 versus 4-1BB co-stimulatory domains show distinct metabolic profiles in patients: Cell Reports www.cell.com/cell-reports...

Vote for your facourite topic for our 2026 LIG meeting

1️⃣ Immunology across the lifecourse
2️⃣ Immunology in a changing world
3️⃣ Signals & senses: external influences on imm.cells
4️⃣ Bench to bedside Immunology

📊 Show results

Congratulations John. So well deserved.

Running a genetic stop sign accelerates oxygen metabolism and energy production in horses Horses are among nature’s greatest athletes, yet the ancestral molecular adaptations fueling their energy demands are poorly understood. Within a clinically important pathway regulating redox and meta...

Running a genetic stop sign accelerates oxygen metabolism and energy production in horses | Science www.science.org/doi/10.1126/...

A French university is offering ‘scientific asylum’ for US talent. The brain drain has started | Alexander Hurst The Trump administration is cutting funding, while specifically targeting institutions like Columbia. No wonder academics want out, says Guardian Europe columnist Alexander Hurst

15 American scientists working in climate, health & astrophysics to be brought to the University of Aix-Marseille , under a 3-year "Safe Place for Science".

Europe positions itself to reverse the decades-long transatlantic brain drain.
🧪
www.theguardian.com/commentisfre...

Congratulations!

Greenpeace must pay hundreds of millions over Dakota pipeline protests, says jury Non-profit said in statement lawsuits like this aimed at ‘destroying the right to peaceful protest’

Fossil fuel companies should be forced to pay the public trillions in damages for the costs of their planetary arson. Instead they are trying to shut down one of the most important and storied environmental groups in the world. It's shameless - and it's not over. www.theguardian.com/us-news/2025...

Philadelphia bet its future on the ‘meds and eds’ now under attack by DOGE Government investment in research, hospitals and universities is what saved older cities after U.S. manufacturing imploded in the 1970s.

www.inquirer.com/columnists/t...

⏲️Only a few days to go until Vaccine Engagement Day 2025!

We'll be highlighting the vital role of vaccines in public health throughout the day 🌟

Want to get involved? Check out our vaccine engagement resources: www.immunology.org/news/bsi-lau...

#CelebrateVaccines

Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism Wang et al. reveal that DLAT, a pyruvate metabolism enzyme, modulates leucine metabolism by directly acetylating the leucine catabolism enzyme AUH at K109, leading to leucine accumulation and sustaine...

Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism: Cell Metabolism www.cell.com/cell-metabol...

Great talk! Well done on very interesting data.

👋Hello Bluesky! We foster collaboration between cancer researchers at @uclofficial.bsky.social, @kingscollegelondon.bsky.social, @qmbci.bsky.social and @crick.ac.uk.

Through our world-class facilities, events, training, and funding opportunities, we aim to support the discoveries that save lives.

I reported on patient outreach in Wisconsin ~10 years ago(?) when the HPV vaccine was rolling out on a large scale and it's really amazing to see this work come to fruition. 🧪

Trump’s war on climate science is pushing us into a dystopian future Withdrawing support for research and scrubbing climate data from US government websites has repercussions for Australia and the world. But there are ways around it.

"Ignoring #climate change won’t make it go away. Like the Ministry of Truth in George Orwell’s classic #dystopian novel, 1984, Trump seems to believe “ignorance is strength”. He’s trying to erase facts about the climate crisis, perhaps to keep people ignorant and subdued." 👇
⚒️ 🧪