2002 vs 2026 Evidence - In current issue, evidence links heart disease to inflammation—and drugs can stop it | Scientific American www.scientificamerican.com/article/new-evidence-links-heart-disease-to-inflammation-and-drugs-can-stop-it/ @nationallipid.bsky.social @aspcardio.bsky.social
More on the amazing story of CETP inhibition with obicetrapib - was associated with attenuated decline in kidney function in patients at high CV risk: Post hoc pooled results from the BROADWAY and BROOKLYN trials doi.org/10.1016/j.aj... @nationallipid.bsky.social @aspcardio.bsky.social
My latest podcast: with Jill Foos - What the 2026 Cholesterol Guidelines Mean for Midlife Women - YouTube www.youtube.com/watch?v=oVYPNX6kJik @nationallipid.bsky.social @aspcardio.bsky.social @escardio.bsky.social @familyheartfdn.bsky.social @menopausesociety.bsky.social
To sum up the Metabolic Vulnerability Index (MVX), we are fortunate to have my friend and developer of the MVX technology, Jim Otvos, provide his great comments (CLICK to ENLARGE). Test is available @Labcorp. I will be getting my test this week @nationallipid.bsky.social @aspcardio.bsky.social
Metabolic Vulnerability Index: MVX - Final Tutorial: UK Biobank Data. Test available @Labcorp pubmed.ncbi.nlm.nih.gov/41220154/ doi.org/10.1016/j.re... @nationallipid.bsky.social @aspcardio.bsky.social @escardio.bsky.social @eassociety.bsky.social @menopausesociety.bsky.social
Metabolic Vulnerability Index (MVX) Tutorial #5: Data from CATHGEN and Intermountain Health Studies. More to come in Tutorial #6. MVX is available @Labcorp
Paper is Open Access at pubmed.ncbi.nlm.nih.gov/36738747/
New mega-analysis showing statin therapy is associated with reduced risk of AD and related out comes, pubmed.ncbi.nlm.nih.gov/41761642/ @nationallipid.bsky.social @aspcardio.bsky.social @fabyollaveras.bsky.social @menopausesociety.bsky.social @eassociety.bsky.social
Metabolic Vulnerability Index (MVX) Tutorial #3: Moving on to the Metabolic Malnutrition Index (MMX) component of the MVX available at Labcorp Open Access at pubmed.ncbi.nlm.nih.gov/36738747/ @nationallipid.bsky.social @aspcardio.bsky.social @eassociety.bsky.social @menopausesociety.bsky.social
AFib and n3FA?? STRENGTH Trial tested high dose n3 carboxylic fatty acid (CA) drug (Epanova). Amongst 6,000 ω-3 CA group and 6,012 placebo group patients without history of AF, 126 (2.1%) and 75 (1.2%) developed AF. SMALL RISK RISKwww.sciencedirect.com/science/article/pii/S2666667726001777
Metabolic Vulnerability Index (MVX) Tutorial #2: After GlycA, one needs to learn more about the Inflammatory Vulnerability Index (IVX) component of the MVX @Labcorp
Paper is Open Access at pubmed.ncbi.nlm.nih.gov/36738747/ @nationallipid.bsky.social @aspca.org @eassociety.bsky.social
For Lipidologists: How are HDLs lipidated via the sterol efflux transporter ABCA1? Here is an advanced review by several notable HDL researchers www.ahajournals.org/doi/10.1161/... @nationallipid.bsky.social @aspcardio.bsky.social @escardio.bsky.social @eassociety.bsky.social
Before continuing with the MVX discussion I first have to go deep into some clinical chemistry re one of its key components, specifically the stable & reliable inflammatory test called GlycA Open access at pubmed.ncbi.nlm.nih.gov/32363327/ @nationallipid.bsky.social @aspcardio.bsky.social
Metabolic Vulnerability Index (MVX) Tutorial #1: More to follow. Test is available at @Labcorp Paper is Open Access at pubmed.ncbi.nlm.nih.gov/36738747/ @nationallipid.bsky.social @aspcardio.bsky.social @familyheartfdn.bsky.social @escardio.bsky.social
See this new useful panel offered at @Labcorp namely the Metabolic Vulnerability Index (MVX). It consists of 6 NMR biomarkersthat help predict mortality rather independent of other risk factors. Stay tuned for much more www.labcorp.com/tests/123590/metabolic-vulnerability-index-mvx-by-nmr
Here is a fabulous "PERSPECTIVE" in Clinical Chemistry superbly written by The NIH Lipid lab team of Rafael Zubiran and Alan Remaley. It fabulously discusses nuances and complexities of CRISPR editing in general and for ANGPTL3 Article is at drive.google.com/file/d/1_hj0... @nationallipid
Do yourself a big favor and listen to this wonderful and informative~30 minute interview with one of the giants of lipidology @JohnKastelein www.youtube.com/watch?v=Bdl-InjA2_s @nationallipid.bsky.social @aspcardio.bsky.social @familyheartfdn.bsky.social @eassociety.bsky.social
Brain Awareness Week is celebrated annually in the third week of March globally. Here is a reminder that cholesterol homeostasis is critical to brain health lnkd.in/e7Mn-XSW @nationallipid.bsky.social @aspcardio.bsky.social @escardio.bsky.social @menopausesociety.bsky.social
Statins enter every cell in the body including the brain as they can pass thru the BBB. Statin's CV benefit comes from reducing apoB, by inhibiting HEPATIC cholesterol synthesis which in turn upregulates LDL receptor & the liver, has far more LDLRs than other peripheral tissues.
Nice to join several top neurologists on this paper. A Preventive Neurology Perspective on Promoting Brain Health and Preventing Cardiovascular Disease. Clin Geriatr Med 2026 doi.org/10.1016/j.cg... @nationallipid.bsky.social @aspcardio.bsky.social @eassociety.bsky.social
There are 2 forms of cholesterol - An alcohol ending in -OL (the active "free" form) & an ester ending in -YL (the storage/transportation form). The esterifying enzymes attach an acYL group (fatty acid) to free cholesterol are ACAT 1 & 2 in specific cells & LCAT (alpha and beta) within lipoproteins
CIMT can be even more important than CAC as vascular pathology appears before calcification. A significant proportion of low-risk individuals may have undetected plaque, justifying reconsideration of early screening strategies. Open access at pubmed.ncbi.nlm.nih.gov/41449009/
More Basics: Apart from biochemistry there is Clinical Chemistry and the cellular machinery that control everything. @nationallipid.bsky.social @aspcardio.bsky.social @familyheartfdn.bsky.social
This is a 9-minute podcast in the famed Lipid Curious series by Visha Priya Pulipati that sort of positions who I am and how I got there. I stumbled into and tried to master the importance of lipids before most clinicians. Enjoy. www.buzzsprout.com/2508586
More of my teaching slides to help all better understand lipid and lipoprotein complexities. Wish you could view the animated versions. Note: lab lipoprotein cholesterol assays measure both free and esterified cholesterol. See if you can figure out why one of obicetrapib's trials was called TULIP.
New AHA pediatric hypertriglyceridemia guideline - www.ahajournals.org/doi/10.1161/ATV.0000000000000195 @nationallipid.bsky.social @aspcardio.bsky.social
Part of the HDL story not usually taught: After receiving TG from apoB particles via CETP, HDLs undergo lipolysis via the actions of hepatic & endothelial lipase. Ultimately the products of lipolysis are very small HDLs & apoA-I which are handled by the Megalin/Cubam complex in the renal tubules
CETP inhibition: A Potential Pathway for Targeting Cholesterol Dysregulation in AD. Open access at www.sciencedirect.com/science/article/pii/S266666772600036X?via%3Dihub @nationallipid.bsky.social @familyheartfdn.bsky.social @aspcardio.bsky.social @menopausesociety.bsky.social
These HDL slides illustrate some of the many complex pathways used by HDL's as it contributes to cholesterol homeostasis. Of course, the HDL-C metric tells you nothing about whether these pathways are occurring or not. If you are using any ratio that includes HDL-C, please cease immediately.
To help all better understand lipoprotein concentrations. Moles are a way of counting #s & 1 mole is the # of particles or 10 to the 23rd power & a nanomole is a billionth of a mole or 10 to the 9th power. HDLs BY FAR are the most numerous particles in plasma & VLDLs & IDLs are by far the fewest.
Here is where we are with PCSK9 inhibitors: 3 on the market, another (new class of drugs) just approved and coming in the near future an oral one. @nationallipid.bsky.social @aspcardio.bsky.social @escardio.bsky.social @familyheartfdn.bsky.social