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Posts by Li Lei

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Phenotypically Wild Barley Shows Evidence of Introgression From Domesticated Barley Multiple studies have reported genetic evidence of crop-to-wild introgression in phenotypically wild accessions of wild barley (Hordeum vulgare ssp. spontaneum). We examined 318 Wild Barley Diversity...

Excited to share our new Molecular Ecology paper with @peterlmorrell.bsky.social, @chaochihl.bsky.social, & collaborators: phenotypically wild barley shows evidence of introgression from domesticated barley in the WBDC collection.
doi.org/10.1111/mec.... #Barley #Genetics

2 months ago 4 2 0 0
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Hi all, please join our session in Plant and Animal Genome Conference next Tuesday afternoon. #PAG2026

3 months ago 0 0 0 0
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Plant cistromics folks, let’s meet at #PAG2026 🌱
Join our Plant Cistromics session (Palm 8) to talk chromatin, regulatory elements & cis-reg networks in crops.
🗓 Tue, Jan 13
🕓 4:00 PM
Come share data, ideas & future collabs!

4 months ago 4 3 0 0
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It’s that time of year again — PAG abstract submissions are open! 🌿 I’m organizing a Plant Cistromics session this year, and we’d love to see your work. Submit an abstract and share your exciting research with the community!

6 months ago 0 1 0 0
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It’s that time of year again — PAG abstract submissions are open! 🌿 I’m organizing a Plant Cistromics session this year, and we’d love to see your work. Submit an abstract and share your exciting research with the community!

6 months ago 0 1 0 0
PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Decoding nature’s grammar with DNA language models | PNAS www.pnas.org/doi/10.1073/... - Serguei Pakhomov was a great co-author for this commentary on PlantCaduceus

9 months ago 2 1 0 0
Phylogenies and biological foundation models Biological foundation models are, at their core, evolutionary comparisons on massive scales. As with all comparative studies, evolutionary nonindependence determines their power. We chart how this aff...

Fascinating read connecting Felsenstein’s 1985 insights to modern biological foundation models. Love the perplexity idea—curious how it could extend to multi-omics & even guide loss functions for phylogenetically balanced training.

8 months ago 0 0 0 0
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Frontiers | Editorial: Crop Domestication and Selection – An Evolutionary View Affecting the Development of Agronomic Traits Crop domestication – the evolution of wild plants for human use – is central to agriculture. Through artificial selection, humans have shaped traits like lar...

Our editorial paper about evolution is out, welcome to check! Thanks for my co editors: Hong An, Tian Xiang, and my postdoc Bliss Beernink. www.frontiersin.org/journals/pla...

10 months ago 1 0 0 0
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Sodium azide mutagenesis induces a unique pattern of mutations Author summary Sodium azide is frequently used as a mutagen for experimental studies in plants. It induces primarily C → T changes. We find that these most often occur when a cytosine (C) is followed ...

New paper w/ @plos.org! @chaochihl.bsky.social identifies a unique mutational pattern among sodium azide-induced mutants. SNPs in 'CC' context and indels. Thanks to @justinfay.bsky.social @lilei0051.bsky.social @giuliafrascarelli.bsky.social @nanoporetech.com et al

journals.plos.org/plosgenetics...

10 months ago 5 3 0 0

I’m incredibly proud of my postdoc, @BlissBeernink, for delivering a fantastic talk at the @JGI Science Forum! Well done, and thank you for your great work! #Science #Research

1 year ago 2 1 0 0

@lbnl_next

1 year ago 0 0 0 0
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Thrilled and honored to share my career development journey with the incredible high school students from Oakland High who visited Berkeley Lab today! Inspiring the next generation of scientists and innovators is truly a privilege. #STEM #CareerDevelopment #NextGenScientists

1 year ago 2 0 1 0
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1,000 Scientist AI Jam Session: Advancing science with the U.S. national labs OpenAI and nine national labs bring together leading scientists for first-of-its kind event.

I’m thrilled to attend the 1,000 Scientist AI Jam Session: Advancing Science with the U.S. National Labs to test their new models—what an incredible opportunity! openai.com/global-affai...

1 year ago 1 0 0 0

Our workshop will be this afternoon at 4pm in palm 8. please come to join us!

1 year ago 0 0 0 0
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Heading to #PAG 32 in San Diego. Welcome to join our workshop of Plant Cistrome on Tuseday 4pm!

1 year ago 1 0 1 0

Thrilled to be invited to review a grant for the European Research Council! Honored to contribute to advancing groundbreaking research on a global scale.

1 year ago 2 0 0 0
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After weeks of hard work and dedication, even through the Thanksgiving break, my collaborators and I successfully submitted two proposals! I am deeply grateful to my amazing collaborators for their invaluable support and efforts throughout the proposal drafting process. Thank you all!

1 year ago 0 0 0 0

I’m thrilled to have been invited to give a job shadow session to Brentwood High School students! I shared my research and my journey to becoming a scientist with them, and they asked so many insightful questions. Thanks to those curious and enthusiastic high school students!

1 year ago 2 1 0 0

Hi all. Dr. Ronan O'Malley and I will organize a workshop of "Plant Cistromics" in #Plant and Animal Conference 2025 in Junary 14th at 4pm in San Diego. Welcome to join us at that time!

1 year ago 3 0 0 0
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Enhancers in Plant Development, Adaptation, and Evolution Abstract. Understanding plant responses to developmental and environmental cues is crucial for studying morphological divergence and local adaptation. Gene

Our review manuscript is out! Welcome to check: doi.org/10.1093/pcp/...

1 year ago 1 1 0 0

This paper from Gaia Cortinovis, Roberto Papa, et al. is now out. Multiple domestications and introductions of common bean beyond the New World make this an interesting system for studying the genetic nature of adaptation. www.nature.com/articles/s41...

1 year ago 0 2 0 0

Chaochih Liu, @lilei0051.bsky.social, and many others contributed to our study of introgression from cultivated into wild barley. ~ 16% of wild barley accessions appear introgressed. Some individuals display domestication-relate traits, but typically, the portion of the genome affected is small.

1 year ago 0 1 0 0

Our manuscript about barley introgression is online now, welcome to read it!

1 year ago 1 0 0 0

I am really excited that my postdoc Bliss Beernink and I finished writing a review paper about plant enhancers in a month and half. That's so impressive! I am proud of our team! We submitted it today! I really appreciate her working so hard to write this manuscript with me.

1 year ago 5 0 0 0

Good trick! I have never used it.

1 year ago 0 0 0 0
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Sodium azide mutagenesis induces a unique pattern of mutations bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

We've found that the common chemical mutagen sodium azide produces a very specific pattern of mutations in a specific nucleotide context. The 2 nucleotide context limits the types of amino acid changes observed.

We also find small indels are more abundant in treated lines.
doi.org/10.1101/2024...

1 year ago 4 3 0 0
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