Our paper (@stoplab.bsky.social), in collaboration with the Nojima lab (@pol2rna.bsky.social @chiheron.bsky.social), on the role of chromatin modifier SETD2 at both ends of the transcriptional cycle, is now published in @emboreports.org 🪅 (1/5)
link.springer.com/article/10.1...
Finally published at long last (at least in the pre-view version). Explore the wild and woolly world of archaeal histones! Interactive archaeal histone graph incluced rdcu.be/fdFjv. Congratulations to first author Shawn Laursen
Are you excited by virology? Would you like to do a PhD? Three fantastic opportunities are available to do joint PhDs between @cvrinfo.bsky.social and @pirbrightinst.bsky.social
Details in the thread below - please share!
Deadline 8th May 2026, fully funded for UK Home students
(1/4)
The Angel of Death did not find Chuck Norris.
Chuck Norris found the Angel of Death.
Remembering the best (fictional) martial arts fight ever captured on film: www.youtube.com/watch?v=NlTy...
Very happy to see this out. 👏 @yinanwan.bsky.social
Bogdan Bintu and team.
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...
This Friday at the @uam-ibmib.bsky.social seminar: Katarzyna Klonowska from the Institute of Biooganic Chemistry PAS in Poznan will give a talk on mutation landscape in tumour suppressor gene syndromes - join us!
We’re recruiting! Three-year, fully funded #postdoc opportunity: pancreatic cancer #epigenetics & potential new treatments (funded by @ncn.gov.pl & @dfg.de ). Collaboration with @akispapantonis.bsky.social, University of Göttingen (OPUS-LAP). See the ad & contact me! drive.google.com/file/d/1vrFd...
Scientists have found a little RNA molecule – small enough to potentially form spontaneously, yet sophisticated enough to copy itself – that cd explain how life on Earth arose. Thanks @edogia.bsky.social of the @philholliger.bsky.social lab! blog.sciencemuseum.org.uk/in-the-begin...
It took a while but it’s finally published!
The GAP activity of SEAC (GATOR) is a metabolic switch that allows cells to quickly respond to changes in amino acid levels, both for inhibition and reactivation.
my head is still spinning from EMBO Selfish Genetic Elements this week! incredible gamut of mostly "non-model" species gives us appreciation and insights into diversity of unusual chromosome dynamics, selfish genes and weird sex. tx @lucasoldini.bsky.social @laurarossevo.bsky.social tanja schwander!
How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?
Excited to share our latest work in @science.org on a new small polymerase.
1/n
Are you a DNMT3 enthusiast wondering how they achieve specificity at CpG islands during development? And why is DNMT3B specifically required for methylation on the inactive X?
We set out to dissect the mechanism, now published in Genes & Development
genesdev.cshlp.org/content/earl...
[1/12]
A vanishing star births a black hole—without the fireworks | Science | AAAS @science.org 🔭🧪 www.science.org/content/arti...
Thrilled to announce that I’ve just opened my research lab at @helmholtz-hiri.bsky.social !
A huge thank you to my mentor Roi Avraham (and lab members!) for the incredible training and support that made this possible.
Excited to share our latest study in Nature Communications ✨
We map how cells clear DNA damage–stalled RNA polymerase II using a stepwise TFIIH → ubiquitin/VCP mechanism, keeping transcription and genome stability on track.
Paper: www.nature.com/articles/s41...
#Genomics #DNADamage #CellBiology
Attention RNA biology and antisense therapy folks: this is HUUUUUUGE!!! Termination windows as therapeutic opportunity!
Sounds super exciting! Good luck and try to enjoy!
I’m super excited to be opening a lab at WEHI. We’ll be focussing on how double-stranded RNA is regulated in cells, how failures in these pathways drive disease and new therapies to manipulate inflammatory responses to RNA.
#newPI #RNAsky
Our new preprint on SMCHD1! We’ve shown SMCHD1’s ATPase activity is critical for function in vivo, and excitingly a new DNA binding domain neighbouring the ATPase domain activates the enzymatic function, which is important for normal chromatin binding.
urldefense.com/v3/__https:/...
Congratulations!
I've joined the Editorial Board of @plosbiology.org
PLOS Biology is the flagship #PLOS journal in the Life Sciences. I'm looking forward to handling terrific cell biology papers for them.
#CellBiology
No joke: I got angry hate mail today for writing an obituary of a Black woman scientist—because the person felt she did didn’t deserve the recognition.
Which just makes me want to share it again: www.nature.com/articles/d41...
The way UK govt funds science is in the midst of a major transition, with creation of a much more direct link between government priorities & UKRI research funding.
My attempt to set in context the biggest upheaval in UK science funding policy since the 1980s:
softmachines.org?p=3252
Discuss #RNA 3' ends and their regulation at the EMBO Workshop "RNA 3' ends and beyond" in #Oxford, United Kingdom, 7–11 September 2026.
Deadline: 4 May 2026
https://meetings.embo.org/event/26-rna3
#EMBORNA3EndsBeyond #RNAsky #LifeSciences #meeting #EMBOevents 🧪
Sign up now for the EMBO Workshop "#RNA metabolism: Perspective from physiology to brain disorder" in Darjeeling, India, 25–28 October 2026.
Deadline: 15 May 2026
https://meetings.embo.org/event/26-rna-metabolism
#EMBOrnaMetabolism #RNAsky #LifeSciences #research #conference #EMBOevents 🧪
Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element www.biorxiv.org/content/10.6...
Join us;
We have an opening for a BBSRC-funded 3-year postdoc position to investigate the mechanisms of mRNA-specific translational regulation of the innate immune system.
#Postdoc #RNA #RBP #MolecularBiology #Virology #RNASky #AcademicJobs
hrwebapp.qub.ac.uk/tlive_webrec...
How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
