Local disorder is associated with enhanced catalysis in an engineered photoswitch The A. sativa LOV2 domain is commonly harnessed as a source of light-based regulation in engineered optogenetic switches. In prior work, we used LOV2 to create a light-regulated Dihydrofolate Reductas...

Excited to share our new preprint on the mechanism of allostery in an engineered photoswitch enzyme. Grateful to have worked on this with James McCormick, @marielle.bsky.social, and @kreynoldslab.bsky.social 🧬🧪🦠
www.biorxiv.org/content/10.1...

Great episode of the Night Science podcast with Harmit Malik @harmitmalik.bsky.social @itaiyanai.bsky.social

youtu.be/UK4Ve-ybNMM?...