Excited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n] rdcu.be/fdqbr

Tumour promotion through the lens of evolution Nature - This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable...

Tumor promotion through the lens of evolution

This review grew out of many long conversations, shared ideas, and lively discussions

It has been a real pleasure to think together with Allan, Paul, Eve, and Abel about how tumours develop and how carcinogens shape cancer risk

rdcu.be/fdC2J

Monthly median Received to Accepted time (days) at Nature Genetics

Real-world clinical utility of tumor whole-genome sequencing in solid cancers - Nature Medicine In a real-world cohort of 888 patients with solid cancers receiving whole-genome sequencing profiling, actionable biomarkers were identified in 73% of patients, and targeted therapies were associated ...

Why should tumor whole genome sequencing (WGS) be done for cancer?
In real practice of medicine study of 888 patients with solid cancers, WGS directly led to clinical consequences in over 40%
www.nature.com/articles/s41...

Here's a short guide to good practices for #8M, that we've prepared from the Equality Commission of @vhio.bsky.social.

2026-018-01 Postdoctoral fellow in cancer immunogenomics - VHIO Under the leadership of Josep Tabernero, VHIO is an internationally recognized cancer center. Its multidisciplinary, collaborative model drives scientific progress and innovative cancer treatments.

‼️Last days to apply for our postdoc position in the group! Please share!!
jobs.vhio.net/en/jobs/7256...

Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis LINE-1 (L1) retrotransposition generates somatic genomic variation in human cancer, but short-read sequencing has limited our understanding of its structural consequences and dynamics. Using long-read...

Today in
@science.org:
We are pleased to present our last work entitled:
"Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis"
by Zumalave et al.
www.science.org/doi/10.1126/...

Today is #WorldCancerDay

~1 in 5 people will develop #cancer in their lifetime

Each diagnosis affects not just one person, but families, communities, and futures

Grateful today for patients, clinicians, researchers & advocates - and to appreciate that progress depends on acting together

#WCD2026

Thanks Santi, very much appreciated!!

Convocatoria abierta para las Becas FERO 2026! 🔬destinadas a impulsar la investigación oncológica traslacional en España. 6 becas en 4 categorías diferentes
👉 toda la info fero.org/para-investi...
#BecasFERO #ConvocatoriaAbierta #OpenCall #FundaciónFERO #FERO

Huge congratulations to Fran on being awarded the ERC Consolidator Grant! 🎉

Such a well-deserved recognition of an outstanding trajectory and a truly creative, exciting proposal on T-cell clonal hematopoiesis.

Can’t wait to see the discoveries that come out of this project.

So proud of you! 👏✨

👏 ¡Enhorabuena Francisco Martínez Jiménez‼️
El jefe del Grupo de Inmunogenómica Computacional del #VHIO ha recibido una Consolidator Grant del @erc.europa.eu para investigar nuevas estrategias de inmunoterapia basadas en clones expandidos de linfocitos T.

➡️ https://linke.to/ERCFranMVHIO_Cast
#ERCCoG

new out in Nature www.nature.com/articles/s41...

Epigenetically driven and early immune evasion in colorectal cancer evolution - Nature Genetics This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.

New @natgenet.nature.com paper from the brilliant @eszterlakatos.bsky.social presents evidence that chromatin alterations disrupt antigen presentation & neoantigens in colorectal cancer. Also that immune escape is part of the "Big Bang", at the outset of CRC growth. www.nature.com/articles/s41...

Fantastic #Blutorial by our friends and colleagues at the @batllelab.bsky.social . We are so happy to collaborate with them.

@meritxellnov.bsky.social and Mireia Novell in the lab have participated in this very important piece on metastatic colorectal cancer. 👏🏼👇🏼👇🏼👇🏼

aacrjournals.org/cancerdiscov...

Postdoc | VHIO, Barcelona
Immunotherapies succeed in only ~20% of cases.
Help us break resistance by engineering the right environment.
Join the Aging & Cancer Lab 🌍
👉 Apply: vhiovidaprogramme.eu/recruitment/ | mauslab.org

Finding somatic mutations in healthy tissue that can lead to cancer, at scale. Yet another path to primary prevention
www.nature.com/articles/s41...
www.nature.com/articles/d41...

5/
As genomic profiling expands, such approaches are vital to balance patient benefit, cost, and sustainability. But will require systematic data generation and sharing to achieve real-world impact. End.

4/
We also model the statistical power needed for clinical implementation of such biomarkers, offering a roadmap for translating non-response biomarkers into clinical practice. Our analysis revealed that we are still underpowered to implement it with existing data

3/
Under stringent analytical control, we found several known and novel biomarkers, many aligned with resistance mechanisms (e.g., KRASG12X in colorectal cancer treated with comb. chemotherapy agents, immune escape events in melanoma patients treated with ICIs). See full list in Supp. Tables

2/
We analyzed data from >2,500 patients with WGS/WTS and matched clinical outcomes — the largest dataset of its kind — to systematically identify non-response biomarkers.

1/
🚀 Excited to share our preprint tackling a key gap in precision oncology: the lack of robust non-response biomarkers to guide clinical decisions.
These markers can spare patients from ineffective treatments and ease pressure on healthcare systems.
www.biorxiv.org/content/10.1...

Working alongside with Fran, a no brainer 👇🏼

🚨 International Postdoctoral Positions Open at VHIO! 🚨
The VHIO VIDA Postdoctoral Program is now open!
We’re a fully funded position for international postdocs to work on cutting-edge exciting projects, develop professionally, and pave the way toward independence.
👉 vhiovidaprogramme.eu

How exercise promotes the immune system vs cancer, working through a gut bacteria metabolite
www.cell.com/cell/abstrac...

End GDP mania: how the world should really measure prosperity The obsession with economic output as a measure of human development puts sustainability on the back burner. Researchers can now help to devise better indicators.

The obsession with economic output as a measure of human development puts sustainability on the back burner

Time to end the GDP mania

Our editorial inspired by a @nature.com paper that looks at how the world should really measure prosperity
🧪 #SGDs #doughnuteconomics
www.nature.com/articles/d41...

Doughnut of social and planetary boundaries monitors a world out of balance - Nature A revised ‘Doughnut’ providing a visual assessment of trends in social deprivation and planetary degradation over the past two decades shows more than doubling of global GDP accompanied by accelerating ecological overshoot but only a modest reduction in human deprivation.

The richest 20% of nations, with 15% of the global population, contribute more than 40% of annual ecological overshoot; the poorest 40% of countries, with 42% of the global population, experience more than 60% of social shortfall 🧪
A new analysis by Fanning & Raworth
www.nature.com/articles/s41...

Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...

In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...

Aberrant basal cell clonal dynamics shape early lung carcinogenesis Preinvasive squamous lung lesions are precursors of lung squamous cell carcinoma (LUSC). The cellular events underlying lesion formation are unknown. Using a carcinogen-induced model of LUSC with no a...

www.science.org/doi/10.1126/...

‘Half the tree of life’: ecologists’ horror as nature reserves are emptied of insects A new point in history has been reached, entomologists say, as climate-led species’ collapse moves up the food chain even in supposedly protected regions free of pesticides

Experts are concerned, as a number of scientists 🧪have recorded huge die-offs of insects in nature reserves around the world. The reported collapse of insect populations in supposedly protected regions is part of a newer phenomenon. 🌏🐜

Read more in @theguardian.com: