The culmination of a fantastic collaboration between our lab and Bob Yauch’s lab that resulted in the uncovering of a proteosomal regulatory mechanism for PP2A. Congratulations to all the authors!
www.nature.com/articles/s41...
Thrilled to share our new work on how the human RAD51 paralogs cooperate to build and stabilize RAD51 filaments, published today in Nature.
www.nature.com/articles/s41...
Congratulations to all authors!
How do SMC complexes load onto DNA to get ready for loop extrusion?
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
The figure was made by @falconierivisuals.bsky.social, so credit for that goes to her
We also discovered 4 previously uncharacterised proteins, which we named centromeric subunits 1-4 (CS module), surprisingly repurposed from the outer kinetochore Dam1/DASH complex. It will be very interesting to see how many other species contain this CS module
Holocentric kinetochore assembles into a self-contained, head-to-head dimers that entrap and loop DNA, creating a point-centromere-like architecture, suggesting that kinetochores might assemble into such foundational "unit modules" to drive diverse centromere architectures across species
Happy to share our latest work on the structure and assembly of holocentric kinetochores! Huge thanks to Ines for a very fruitful collaboration, Claudio for all the support, and congratulations to Christine and all co-authors!
www.biorxiv.org/content/10.1...