We found that mitochondrial transport was disrupted across FUS-ALS mice, whereas signalling endosome trafficking was selectively impaired in mice with innervation deficits.
This has been a big collaborative effort from many teams at IoN and Harwell @jamessleigh.bsky.social @dvillarroelc.bsky.social

Very excited to share our latest preprint! We looked at loss and gain of function, innervation, reinnervation, and in vivo axonal transport in a FUS-ALS mouse model!

www.biorxiv.org/content/10.1...

@uclqsion.bsky.social @beccasimkin.bsky.social @andrewtosolini.bsky.social @frattalab.bsky.social

An image montage advertising NeuroBioUK - 12th of September 2025 in York. The image is York cathedral superimposed over a fluorescent cortex mouse section coloured to look a bit like a dawn sky.

Registration is now open for NeuroBioUK 2025!
This year we're looking forward to hearing from our plenary speaker @cathyabbott.bsky.social. As ever, all other talks chosen from submitted abstracts so get submitting - we can't wait to see you there!

neurobiouk.sites.sheffield.ac.uk/registration

Expansion microscopy reveals nano-scale insights into the human neuromuscular junction Ramadan et al. employ expansion microscopy to visualize neuromuscular junctions in human and mouse muscles. Their findings demonstrate expansion microscopy as an accessible and cost-effective approach...

New paper from the lab 🚨: Expansion microscopy reveals nano-scale insights into the human neuromuscular junction: Cell Reports Methods www.cell.com/cell-reports...

Axonal pathophysiology in ALS: investigating the role of FUS-ALS mutations in axonal damage and regrowth at University College London on FindAPhD.com PhD Project - Axonal pathophysiology in ALS: investigating the role of FUS-ALS mutations in axonal damage and regrowth at University College London, listed on FindAPhD.com

If you are looking for a PhD, are passionate about neurobiology and enjoy microscopy, come and join us for a PhD project on axonal pathophysiology in ALS!

www.findaphd.com/phds/project...
Applications close on Friday 4th July 2025

@mndassoc.bsky.social
@uclqsion.bsky.social

If you're struggling to visualise mouse NMJs, we've got a protocol just for you!

bio-protocol.org/en/bpdetail?...

Dissection and whole-mount immunofluorescent staining of mouse hind paw muscles for #NMJ analysis

Lovely work from Rebecca Simkin @uclqsion.bsky.social @nicolbirsa.bsky.social‬