ICYMI: 📰 RTI Messenger, Issue 57
➰️ Keeping you in the loop ➰️

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#RTImessenger #RNATx @umasschan.bsky.app

Hot off the press from the RTI: A Unified Mechanism of +1 Ribosomal Frameshifting

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A Unified Mechanism of +1 Ribosomal Frameshifting - PubMed Ribosomes decode 3-nucleotide codons and move in 1-codon increments to maintain the messenger RNA (mRNA) frame thereby accurately producing the encoded protein. In special cases, including viral genomes...

Hot off the press from the RTI: A Unified Mechanism of +1 Ribosomal Frameshifting
pubmed.ncbi.nlm.nih.gov/41974538/?ut... #RNA #RNATherapeutics

Post-Transcriptional Size-Dependent Expression of the Fission Yeast Cdc13 Cyclin - PubMed The major fission yeast cyclin, Cdc13, has been shown to increase in concentration in correlation with cell size, and has been proposed to thereby regulate cell size at division. However, the mechanism...

Hot off the press from the RTI: Post-Transcriptional Size-Dependent Expression of the Fission Yeast Cdc13 Cyclin
pubmed.ncbi.nlm.nih.gov/41929151/?ut... #RNA #RNATherapeutics

Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching Visualizing the structures of small proteins and complexes has been a longstanding challenge in single-particle cryo-EM. Some of these targets have been successfully resolved by binding to antibody fragments...

🧬 New BioRxiv preprint from the RTI: Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching buff.ly/2GRES82 #RNA #RNATherapeutics @umasschan.bsky.social

Hot off the press from the RTI: Bacteria producing the bioplastic polyhydroxybutyrate kill the nematode Caenorhabditis elegans

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Bacteria producing the bioplastic polyhydroxybutyrate kill the nematode Caenorhabditis elegans - PubMed Bacteria, both individually and as symbionts of other organisms, significantly influence ecosystems by providing nutrients and metabolizing exogenous compounds. Some bacteria polymerize small organic...

Hot off the press from the RTI: Bacteria producing the bioplastic polyhydroxybutyrate kill the nematode Caenorhabditis elegans
pubmed.ncbi.nlm.nih.gov/41961891/?ut... #RNA #RNATherapeutics

Registration for the 8th annual RNA Therapeutics: From Concept to Clinic is filling fast and closing soon. Join us June 24–26, 2026 for three days of cutting-edge science and translational insights — secure your spot now: buff.ly/vi22rN6 #RNATherapeutics #RNATx2026 @UMassChan.bsky.social

The RTI's @biorxivpreprint.bsky.social channel is now live!

Hot off the press from the RTI: Efficient Downregulation of Flt-1 Mediated by Splice Switching ASO in Murine Endothelial Cells

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Efficient Downregulation of Flt-1 Mediated by Splice Switching ASO in Murine Endothelial Cells - PubMed Impaired angiogenesis is a common feature of several pathological conditions, including neuromuscular disorders. Such vascular defects not only contribute to disease progression but also may compromise...

Hot off the press from the RTI: Efficient Downregulation of Flt-1 Mediated by Splice Switching ASO in Murine Endothelial Cells
pubmed.ncbi.nlm.nih.gov/41933450/?ut... #RNA #RNATherapeutics

Early bird registration is ENDS TODAY for our 8th annual #RNA Therapeutics: From Concept to Clinic, June 24–26, 2026 @umasschan.bsky.social‬ #RNATx2026 buff.ly/vi22rN6

Designing scientific careers, not just experiments Universities are rethinking how they prepare scientists for careers beyond the bench. From myIDP to Vanderbilt’s Career Architect, programs help trainees clarify values, explore options and build…

Designing scientific careers, not just experiments highlights the work the RTI's Cynthia Fuhrmann is doing with myID! buff.ly/6NTy05J
@UMassChan.bsky.social @asbmb.bsky.social #myIDP #STEMcareers

Hot off the press from the RTI: Testis-specific lncRNA Teshl regulates acrosome biogenesis to maintain sperm structure and function

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Testis-specific lncRNA Teshl regulates acrosome biogenesis to maintain sperm structure and function - PubMed Testis-specific lncRNA Teshl regulates acrosome biogenesis to maintain sperm structure and function

Hot off the press from the RTI: Testis-specific lncRNA Teshl regulates acrosome biogenesis to maintain sperm structure and function
pubmed.ncbi.nlm.nih.gov/41913266/?ut... #RNA #RNATherapeutics

Fen-Biao Gao named fellow of the American Association for the Advancement of Science Fen-Biao Gao, PhD, has been named a fellow of the American Association for the Advancement of Science.

Congratulations to the RTI's Fen-Biao Gao, PhD, on being named a fellow of the American Association for the Advancement of Science today for advancing our understanding of disease pathogenesis in frontotemporal dementia: direc.to/o3Dn

#FTD #AAASfellow
@aaas @umasschan

The Approval of Redemplo for Familial Chylomicronemia Syndrome and the Many Flavors of GalNAc-Oligonucleotides - PubMed In the fourth quarter of 2025, a press release announced the approval of the eighth small interfering RNA (siRNA)-based therapeutic. Redemplo (plozasiran), developed by Arrowhead Pharmaceuticals, is…

Hot off the press from the Alterman & Khvorova labs: The Approval of Redemplo for Familial Chylomicronemia Syndrome and the Many Flavors of GalNAc-Oligonucleotides

buff.ly/chHxiUY #RNA #RNATherapeutics @UMassChan

Fen-Biao Gao named fellow of the American Association for the Advancement of Science Fen-Biao Gao, PhD, has been named a fellow of the American Association for the Advancement of Science.

UMass Chan congratulates Fen-Biao Gao, PhD, on being named a fellow of the American Association for the Advancement of Science today for advancing our understanding of disease pathogenesis in frontotemporal dementia: direc.to/o3Dn

#FTD #AAASfellow @aaas.org @rti-umasschan.bsky.social

ONE WEEK left for early registration to #RNATx2026 happening June 24-26! We know travel funding is limited for scientific conferences. Travel awards, inclusivity grants, & family support awards are available for trainees & ECRs; you must apply by April 3. @UMassChan.bsky.social buff.ly/vi22rN6

Divalent siRNA for prion disease - PubMed Prion protein (PrP) lowering is effective in animal models of prion disease and is being tested clinically in prion disease patients, but there remains a need for more potent PrP-lowering drug candidates....

Hot off the press from the RTI: Divalent siRNA for prion disease
pubmed.ncbi.nlm.nih.gov/41867745/?ut... #RNA #RNATherapeutics

Post-Transcriptional Size-Dependent Expression of the Fission Yeast Cdc13 Cyclin The major fission yeast cyclin, Cdc13, has been shown to increase in concentration in correlation with cell size, and has been proposed to thereby regulate cell size at division. However, the mechanism...

🧬 New BioRxiv preprint from the RTI: Post-Transcriptional Size-Dependent Expression of the Fission Yeast Cdc13 Cyclin www.biorxiv.org/content/10.1... #RNA #RNATherapeutics @umasschan.bsky.social

Hot off the press from the RTI: RNAi-mediated p38δ silencing mitigates anthracycline cardiotoxicity in female mice

pubmed.ncbi.nlm.nih.gov/41874387/?ut... #RNA #RNATherapeutics @UMassChan

The Approval of Redemplo for Familial Chylomicronemia Syndrome and the Many Flavors of GalNAc-Oligonucleotides - PubMed In the fourth quarter of 2025, a press release announced the approval of the eighth small interfering RNA (siRNA)-based therapeutic. Redemplo (plozasiran), developed by Arrowhead Pharmaceuticals, is the...

Hot off the press from the RTI: The Approval of Redemplo for Familial Chylomicronemia Syndrome and the Many Flavors of GalNAc-Oligonucleotides
pubmed.ncbi.nlm.nih.gov/41877501/?ut... #RNA #RNATherapeutics

RNAi-mediated p38δ silencing mitigates anthracycline cardiotoxicity in female mice - PubMed The anthracycline antibiotic doxorubicin (DOX) is a potent chemotherapy drug, but its use is limited by dose-dependent cardiotoxicity. We previously reported that genetic deletion of p38δ protects female...

Hot off the press from the RTI: RNAi-mediated p38δ silencing mitigates anthracycline cardiotoxicity in female mice
pubmed.ncbi.nlm.nih.gov/41874387/?ut... #RNA #RNATherapeutics

Hot off the press from the RTI: An siRNA targeting S6k1 identifies photoreceptor phospholipid metabolism as a contributor to lipid buildup in age-related macular degeneration

buff.ly/wHy3jKw #RNA #RNATherapeutics @UMassChan

An siRNA targeting S6k1 identifies photoreceptor phospholipid metabolism as a contributor to lipid buildup in age-related macular degeneration - PubMed Age-related macular degeneration (AMD) remains a leading cause for visual impairment in the elderly. We recently showed that activated mammalian target of rapamycin complex 1 (mTORC1) in photoreceptor...

Hot off the press from the RTI: An siRNA targeting <em>S6k1</em> identifies photoreceptor phospholipid metabolism as a contributor to lipid buildup in age-related macular degeneration
pubmed.ncbi.nlm.nih.gov/41858838/?ut... #RNA #RNATherapeutics

RTI's Jon Watts speaking at OPT today on Prime Editing with Chemically Modified Templates and Modification-Tolerant Polymerases #RNATherapeutics @JWattsgroup.bsky.social

Hot off the press from the RTI: Lowering the HTT1a transcript as an effective therapy for Huntington's disease in a knockin mouse model

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Cynthia Fuhrmann recognized with Distinguished Service Award from National Postdoctoral Association The honor recognizes sustained efforts or leadership contributions to positively impact the career development of postdoctoral scholars.

Cynthia Fuhrmann recognized with Distinguished Service Award from National Postdoctoral Association
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#NPAW #nationalpostdoc @UMassChan.bsky.social

Lowering the HTT1a transcript as an effective therapy for Huntington's disease in a knockin mouse model - PubMed Lowering <i>huntingtin (HTT)</i> transcript levels has been a major focus of therapeutic development for Huntington's disease (HD), but which transcript should be lowered? HD is caused by a CAG repeat...

Hot off the press from the RTI: Lowering the <em>HTT1a</em> transcript as an effective therapy for Huntington's disease in a knockin mouse model
pubmed.ncbi.nlm.nih.gov/41849583/?ut... #RNA #RNATherapeutics