Fifteen Years of PNPLA3: Transforming Hepatology Through Human Genetics Steatotic liver disease (SLD), caused by excess lipid accumulation in hepatocytes, is now a leading global liver condition triggered by metabolic dysfunction, alcohol, toxins and heritable factors. T....

A short overview of the PNPLA3 research field and of the new Liver International Special Issue! Fifteen Years of PNPLA3: Transforming Hepatology Through Human Genetics @stefano-romeo.bsky.social onlinelibrary.wiley.com/doi/10.1111/...

Review Article Metabolic Dysfunction–Associated Steatotic Liver Disease Giovanni Targher, M.D., Luca Valenti, M.D., and Christopher D. Byrne, M.B., Ch.B. Panel A: Factors related to insulin resistance and metabolic dysfunction, diet and environmental exposures, and genetic and epigenetic factors are the main drivers of MASLD development and its progression throughout the entire spectrum of liver disease. Panel B: Female sex and hormonal factors can also modulate the development and progression of MASLD.

MASLD has become the most common chronic liver disease worldwide. The authors review the features of the disease as well as pharmacotherapies targeting the associated liver and cardiovascular–renal–metabolic issues. Learn more: nej.md/4lpS4F0

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