Thank you 😊😊

🎄 𝐂𝐡𝐫𝐢𝐬𝐭𝐦𝐚𝐬 𝐋𝐢𝐩𝐢𝐝 𝐓𝐢𝐦𝐞! 🎄

Thrilled to share a special pre-holiday gift to 𝗟𝗼𝗹𝗶𝗰𝗮𝘁𝗼 & 𝗡𝗶𝗰𝗸𝗲𝗹 𝗟𝗮𝗯𝘀!

𝐏𝐈(𝟒,𝟓)𝐏𝟐 𝐚𝐬𝐲𝐦𝐦𝐞𝐭𝐫𝐲 is essential for the unconventional secretion of 𝐅𝐆𝐅𝟐, driving rapid formation of a lipidic membrane pore, enabling membrane translocation ⏩⏩

🔗 www.nature.com/articles/s41...

🎉 Congratulations to the winners of the Best Poster Awards at #BiomembraneDays2025 sponsored by @lipotype.bsky.social

🏆Manpreet Kaur (with @fabiololicato.com &W. Nickel)
🏆Jana Kroll (@janakroll.bsky.social @mdc-berlin.bsky.social)
🏆Ha Ngoc Anh Nguyen (with @jamessaenz.bsky.social)

🚀Science rocks!

This work is the result of a shared @dfg.de grant between @walter-nickel-bzh.bsky.social and me, carried out by our joint PhD student @manpreet0700.bsky.social at @uniheidelberg.bsky.social @bzh-hd.bsky.social . A great team effort! 🙌

If our hypothesis holds, disrupting PI(4,5)P₂ asymmetry in cells should slow FGF2 translocation. To test this, @manpreet0700.bsky.social introduced PI(4,5)P₂ micelles in the media—enriching the outer leaflet and disturbing the natural asymmetry. And yes, it made a difference.

Plasma membrane transbilayer asymmetry of PI(4,5)P2 drives unconventional secretion of Fibroblast Growth Factor 2 Unconventional secretion of Fibroblast Growth Factor 2 (FGF2) is based upon direct self-translocation across the plasma membrane, a process that involves the transient formation of a lipidic membrane ...

🚨 Lipid Time! 🚨
Excited to share our latest story now on @biorxiv-biochem.bsky.social !
Our brilliant PhD student @manpreet0700.bsky.social , together with @walter-nickel-bzh.bsky.social and myself, shows how PI(4,5)P₂ asymmetry in the plasma membrane drives the unconventional secretion of FGF2!
👇👇👇

If someone ever asks me a question “What is your happy place?” My answer would be, A) in lab, pipetting, B) Talking about science, anywhere anyday anytime, that’s my happy place