📎 www.reuters.com/legal/litig...

The pharma arms race just moved to silicon.

Would you trust an AI-designed drug more or less than a traditional one?

Same day, Amazon launched a biotech AI tool. The entire pharma industry just shifted gears.

For anyone on GLP-1 meds: AI-accelerated development could mean better formulations, faster approvals, fewer side effects, and more options.

The next drug that actually works might be AI-designed.

Novo Nordisk just partnered with OpenAI to deploy AI across drug discovery, manufacturing, and commercial operations. Not a pilot. Full deployment.

The context: Eli Lilly got oral GLP-1 Foundayo approved. Zepbound is gaining ground. Novo is behind.

Short-term budget fix. Long-term health cost.

This tension will only get worse as demand grows and prices stay high.

The question is no longer if GLP-1s work. It's who actually gets to use them.

12% of U.S. adults take a GLP-1. The meds are doing exactly what they promised.

But the people who need them most are being cut off first. Low-income patients on Medicaid.

California, Pennsylvania, South Carolina, and New Hampshire just dropped Medicaid weight-loss coverage.

Michigan raised the BMI requirement to 40.

NYC and Boston are slashing city employee plans.

Spending on these meds jumped from $13.7B to $71.7B in five years. A 5x spike.

States panicked.

GLP-1s cut U.S. adult obesity from 40% to 37% in two years. The first real drop in decades.

Then the bill arrived.

🧵

What's your biggest GLP-1 struggle right now?

A. Side effects spiking after a dose increase
B. Hunger creeping back by day 5
C. Eating so little you worry about nutrition
D. The fear of eventually stopping the meds

Drop a letter.
The most picked one is mojo's next post.

Source: E! News, USA Today, Page Six

How many tries did it take you to find the right fit?

No pretending it was willpower. mojo's seen too many people quit after one bad try. Three meds, three very different reactions. Your body decides, not you.

She lost 50 lbs. Not 30, she specifically corrected that. Dec 2025 she posted a video: "I've had plastic surgery over the years, and I use Mounjaro." "I'm pain-free now. I can play tag with my son."

Then came the weight loss. Three tries before anything worked.
Ozempic → nauseous holding her son, stopped
Wegovy → vomiting so bad she couldn't lift her head, lost 30 lbs but couldn't function, stopped
Mounjaro → her body finally accepted it

She got tested. It was. Turned out to be steroid injections from a C-section and breast reduction years ago, quietly accumulating in her body the whole time. She had no idea.

She wanted to tell everyone to go to hell. But scrolling through, she noticed something different. Doctors in the comments saying this wasn't weight gain. It looked like Cushing syndrome. Cortisol through the roof. Fatal if untreated.

Feb 2024, she went on Jimmy Fallon. Next day the internet exploded. Not because of anything she said. Her face was swollen beyond recognition. Moon face. Fat. Old. The comments were brutal.

"I've had plastic surgery over the years, and I use Mounjaro. Sorry to whoever feels let down."

Amy Schumer went on Instagram and told everyone exactly how she lost 50 lbs. Not to look hot. To survive.

② Pinch the fat: The pressure distracts your brain from the prick.

③ Warm it up: Let it sit at room temp for 15 mins to prevent cold stinging.

Deep breath. Press. You've got this.

Stared at your belly for 3 mins and couldn't press the button? You're up against your brain's natural defense mechanism.

3 facts to ease your fear:

① Tiny needle: 4mm is as thin as 2 hairs. Hits fat, not nerves. Barely felt.

Why obesity drugs work better for some people: these genes hold clues Nature - Study of almost 28,000 people also identifies genetic variants that raise the risk of gastrointestinal side effects from GLP-1 medications.

Sources: Nature, Washington Post
www.nature.com/articles/d4...
www.washingtonpost.com/health/2026...

Clinical trials already hinted that 10-15% of people are low responders. Now we have the receipts.

Genetics aren't destiny. Dose, habits, and duration still matter.

But if the scale isn't moving, stop blaming your willpower.
It's just biology.

If your GLP-1 isn't working, you didn't fail.

A new 23andMe study of 28,000 people just confirmed it. Variants in your GLP-1R and GIPR genes directly affect your weight loss and your side effects.

🔗 Source Study: Published in the BMJ
www.independent.co.uk/news/health...

A new BMJ study of 600,000 veterans shows GLP-1 doesn't just reduce weight. It lowers the risk of alcohol, nicotine, and other addictions by 14%.

It alters the brain's reward system, turning off the constant cravings for dopamine.

It was never your lack of willpower. Your brain was just too loud.

GLP-1 medications don't just move a number on the scale.
They shift the entire picture, cardiovascular risk, blood sugar, liver health, metabolic health.

You're not chasing one digit.
You're rebuilding your whole health.

This World Health Day, we're here for all of you.
Not just the weight.

• Your blood pressure is trending down
• Your HbA1c is improving
• You're sleeping through the night again
• You climbed stairs without losing your breath

You stepped on the scale this morning.

The number didn't move.
And just like that. Your whole day felt like a failure.

But here's what the scale can't tell you: 👇

#WorldHealthDay #GLP1 #MetabolicHealth

Source: Abrasel survey (1,417 establishments), journalist @pavarini
x.com/pavarini/st...

Has GLP-1 changed how you eat with friends?