A tour de force study from Taipale&Yin labs. It expands the vocabulary of the Regulatory Code by adding 1131 TF:TF composite motifs that are different from the individual TF motifs. The new composite motifs are enriched in cell-type specific elements and active in vivo
www.nature.com/articles/s41...
Great collaboration between current and former members of my lab including Nagham Khouri-Farah and @EmmaWentWin, the Skene Lab @n_skene , and the Leslie lab at Emory. Stay tuned for accessiblity data revealing cell type specific enhancers!
We also integrate with human genetic data revealing cell types that contribute to both normal facial variation and craniofacial disease risk. There's even some evo devo tidbits including cell types that are likely to contribute to differences in human and neanderthal morphology
We do careful cell type and subtype identification revealing significant numbers of Cranial Neural Crest cells (CNCCs) from primary tissue for the first time. We also integrate with mouse and spatial human gene expression to identify specific subtypes of mesenchyme and ectoderm.
Happy to present the first preprint from my lab after relocating @CHOP_Research @ChildrensPhila Here we describe gene expression at the single cell level across major milestones of human and mouse development. preprint here: https://buff.ly/3PFWNoG
Impressive study from Alex Stark lab identifying 3 new types of silencer elements in Drosophila
New TF binds a particular isolated motif in non-accessible sites to recruit G9a. Deletion of these elements can lead to upregulation of nearby gene
www.sciencedirect.com/science/arti...