Huge thanks to my co-authors: Judy Chen, Bin Wan @wanb.bsky.social, Paule Joanne Toussaint, Alan C. Evans, and Sherif Karama for making this work possible!

Mediation analysis reveals 4 latent factors with distinct neural substrates. Different exposome domains shape cognitive development through separable brain mechanisms

Family environment shows the strongest spatial overlap with g-related brain patterns. Parental mental health and socioeconomic factors top the list

Brain maturation tied to g and the exposome converges on temporal, limbic, and frontal regions

Separable Brain Maturation Patterns Mediate Exposome Influences on Cognitive Development: a pure longitudinal study
‼️In 1,112 adolescents, we mapped 4,882 multimodal brain features × 112 exposome
✅ uncover the separable neural mechanism linking exposome to cognition
🔗 www.biorxiv.org/content/10.6...

Grateful to work with an incredible team: Yasser Iturria-Medina, Gleb Bezgin, Paule Joanne Toussaint, Ke Xie @kexie.bsky.social, Liang He, Judy Chen, Kirsten Hilger @kirstenhilger.bsky.social, Erhan Genç @erhangenc.bsky.social, Alan Evans & Sherif Karama

Our model showed strong effectiveness and high robustness (r > 0.98 at 500 bootstraps)

Stronger cognition associations ➡️ higher age-dependence in the associations

sMRI > DTI/RSI; global network attributes > local ones

Frontal, temporal and occipital regions showed the strongest associations with g factor

Excited to share our new paper in @commsbio.nature.com
Comprehensively mapping brain structure-cognition associations
‼️16,563 structural features ➡️ 8 cognitive measures
In 8,534 youth from the ABCD Study.
🔗 doi.org/10.1038/s420...

Huge thanks to all coauthors and the ABCD group!

4️⃣Suggestions for personalized intervention strategies and identification of targeted populations

3️⃣Causal effects from cognition and personality to mental health and the corresponding brain structural, pubertal, and environmental factors

2️⃣Mediation pathways from cognition and personality to mental health, and the corresponding brain structural, pubertal, and environmental factors

1️⃣Flowchart of the analysis

📢New Preprint! We present a data-driven causal framework (N=4501) linking cognitive & personality traits ➡️psychopathology, highlighting brain🧠pubertal🧬environmental🏡 interactions, and suggesting personalized intervention strategies.
🔗 biorxiv.org/content/10.64898/2025.12.25.696521v1

📢New Preprint:😃Brain Structure and Cognitive Ability during Adolescence (N=8534)‼️Regional structure, morphometric similarity (MRI), and structural connectivity (DTI) >> Hubs of critical maturation🧠‼️ doi.org/10.1101/2024...