An announcement of keynote speaker Alex Rives for Summer RosettaCon 2026. It shows his picture and notes that he is associated with Massachusetts Institute of Technology and Broad Institute, and that his talk will be August 4, 2026 at 7:30 p.m. It has the Rosetta Commons logo in the upper right corner. It states at the bottom to “Register @ rosettacon.org.” There is solid teal at the bottom with connected hexagon designs in the corners.

Summer RosettaCon 2026’s night two keynote speaker is Alex Rives, a leader in the AI community. Focused on responsible AI development, Alex works to use AI to accelerate scientific discoveries in biology for the greater good, including his work on Evolutionary Scale Modeling. zurl.co/N7N0e

A congratulations announcement to awardees of the NSF Graduate Research Fellowship Program in 2026. It lists the names of RaMP Trainees: Nicolas Langdon, Raksha Pradeep, & Miranda Simpson, RaMP Alumni: Ali Mobedi, and REU Alumni: Dawning (Jiajia) Fu, Samantha Schulte & Richard Zhu. The image is a web of connected molecules. The background is a light teal with some hexagons on it. The Rosetta Commons logo is in the upper right corner.

Update: Congratulations to our seven student awardees for the NSF Graduate Research Fellowship Program!

A congratulations announcement to awardees of the NSF Graduate Research Fellowship Program in 2026. It lists the names of RaMP Trainees: Nicolas Langdon, Raksha Pradeep, & Miranda Simpson, RaMP Alumni: Ali Mobedi, and REU Alumni: Samantha Schulte & Richard Zhu. The image is a web of connected molecules. The background is a light teal with some hexagons on it. The Rosetta Commons logo is in the upper right corner.

Congratulations to our six student awardees for the NSF Graduate Research Fellowship Program! We are so proud of you! Our pride extends to all our RaMP and REU students (current and alumni) who applied for the program. We can’t wait to see what you all accomplish in the years to come.

An announcement of the Summer RosettaCon 2026 Bootcamp/Hackathon How to Train Your Model on August 2 to 8, 2026 at the University of Washington in Seattle, WA. It states that more info can be found at rosettacon.org. The image shows a standing man typing on a laptop. The laptop has an image of a golden dragon. The back of the laptop has golden lines and code language coming out of it that connect to a yellow and golden model of a protein. The background is teal with hexagons in the bottom corners. The Rosetta Commons logo is in the upper left corner.

The How to Train Your Model Bootcamp/Hackathon will not only enhance your machine learning skills in protein design, but also your conference experience. The application deadline is May 1. And don’t forget, co-registration with Summer RosettaCon is required. Registration closes May 15. zurl.co/J65jT

We’d like to thank the course instructors Ian Anderson (UC Davis), Ben Orr (UCSF), and Mary Reilly (UC Davis) for putting this course together and sharing it with the community.

This course provides a practical, beginner-friendly overview of modern AI/ML tools for protein structure prediction and design, including AlphaFold, ESMFold, ProteinMPNN, and RFdiffusion, along with the workflows that connect them. Start the course today. zurl.co/DjX30

An announcement of two presentations from the protein design workflows group. The first is BioExcel Building Blocks by Adam Hospitall and the second is BoltzGen by Hannes Stark. It is announced that the talks are April 14, 2026 at 5 p.m. CET or 11 a.m. ET via Zoom. There are two images to represent each presentation. BioExcel shows lego looking yellow and teal pieces with arrows between them. BoltzGen shows protein spirals that are mainly blue, with one yellow and one pink spiral.

Tomorrow, April 14 is the next Protein Design Workflows Group presentation. Join us via Zoom for two presentations: BioExcel Building Blocks with Adam Hospital and BoltzGen with Hannes Stark, followed by group discussions. For more information, join the group’s mailing list: zurl.co/5UenJ.

An announcement of general registration being open for Summer RosettaCon 2026 through May 15. It has a picture of a previous attendee presenting her poster to three other attendees. There is the Rosetta Commons logo in the upper right corner. It also states that the conference is August 3 to 7, 2026 at the University of Washington in Seattle, WA. It gives rosettacon.org as the location to register and announces the theme as “Biomolecule engineering: From principle to practice” It has hexagon shapes in the corners on top of a teal background.

Summer RosettaCon brings together the Rosetta community each year for engaging presentations and lively discussions that can lead to new collaborations and discoveries. From undergrads to Principal Investigators, explore advances in protein design with our community.
rosettacon.org

There is an image of green, purple, and teal protein spirals on a black background with the announcement of the new RDF3 tutoritals being available. Additional text states “Whether you’re just starting with RFdiffusion3 (RDF3) or looking ot refine your design workflows, these three new tutorials for RFD3 guide you step-by-step through creating new protein structures for your design projects. Learn more at rosettacommons.org/news.” The Rosetta Commons logo is in the upper right corner. The background is a light teal with some hexagons in the corners.

Three RFdiffusion3 (RFD3) tutorials are now available. These tutorials walk you through how to use RFD3 to generate structures for: protein-protein interface design, enzyme design, and nucleic acid binder design, and can be expanded to other areas of interest. Check them out @ zurl.co/og3XK

An announcement of the last chance to register for Summer RosettaCon 2026’s conference at the early bird rate. It has a picture of two previous attendees, one of whom is giving a thumbs up. There is the Rosetta Commons logo in the upper right corner. It also states that the conference is August 3 to 7, 2026 at the University of Washington in Seattle, WA. It gives rosettacon.org as the location to register and announces the theme as “Biomolecule engineering: From principle to practice” It has hexagon shapes in the corners on top of a teal background.

Today is the last day to register for Summer RosettaCon 2026 at the early bird rate. We hope you’ll join us in Seattle, WA as we gather and discuss this year’s theme, “Biomolecule Engineering: From Principle to Practice.” Register today!
rosettacon.org

An announcement of two presentations from the protein design workflows group. The first is AI.zymes by Adrian Bunzel and the second is BinderFlow by Carlos Chacon. It is announced that the talks are March 31, 2026 at 5 p.m. CET or 11 a.m. ET via Zoom. There are two images to represent each presentation. AI.zymes shows a protein that is gray, black, and blue in the middle. BinderFlow shows protein spirals that are yellow, purple, and red.

Tomorrow, March 31 is the next Protein Design Workflows Group presentation. Join us via Zoom for two presentations: AI.zymes with Adrian Bunzel and BinderFlow with Carlos Chacón, and thoughtful discussions. For more information, join the group’s mailing list: groups.google.com/g/protein-de....

There is a screenshot of the rc-run github page with the announcement of the new tool being available. Additional text states “We are pleased to announce a new Rosetta Commons workflow optimization tool: rc-run. Rc-rcun (invoked as rc) is a command-line utility tool for running containerized and native biomolecular software. Learn more at rosettacommons.org/news.” The Rosetta Commons logo is in the upper right corner. The background is a light teal with some hexagons in the corners.

With the goal of becoming a seamless part of your daily computational workflow, we introduce the new utility tool rc-run. Explore rc-run @ github.com/RosettaCommons/rc, then let us know any feedback on additional tools or applications that you would like rc-run to support through the github page.

A picture of Hannah Wayment-Steele along with the text “Member Spotlight, Hannah Wayment-Steele, Asst. Prof. of Biochemistry, University of Wisconsin-Madison.” It also includes a quote that states “I value the openness Rosetta has around science, because it helps fuel scientific growth.” The background is a light orange. The Rosetta Commons logo is at the top and spiral teal and orange proteins are at the top and bottom of the image.

Meet Hannah! Hannah’s lab’s major aim is to obtain a predictive understanding of protein dynamics by combining deep learning and experiments to better understand how biomolecular dynamics works. Learn more about Hannah and her lab in our March 2026 newsletter.
zurl.co/Lz6JN

An announcement partly with an image and partly with text for an upcoming bootcamp/hackathon as part of Summer RosettaCon 2026. The image shows a standing man typing on a laptop. The laptop has an image of a golden dragon. The back of the laptop has golden lines and code language coming out of it that connect to a yellow and golden model of a protein. The background has blue walls with computer codes written on them. The text reads “Get ready to take your machine learning skills in protein design to the next level. August 2 - 8, 2026, Summer RosettaCon 2026 Bootcamp/Hackathon, How To Train Your Model, University of Washington - Seattle, WA. For more information and to apply, please visit: rosettacommons.org/education/workshops. In the bottom left is the Rosetta Commons logo.

Bookending Summer RosettaCon, intermediate/advanced machine learning researchers are invited to our How to Train Your Model Bootcamp/Hackathon. Join us for an immersive, project-based learning experience for moving beyond "out-of-the-box" models. Apply today. sites.google.com/omsf.io/htty...

Four pictures of participants during the hackathons and one group picture of all attendees. The pictures show students and staff working at tables on laptops. The group photo shows palm trees in the background. The text says “Megathon 2026, Highlights from Puerto Rico.” The Rosetta Commons logo is on the bottom left.

What do well-documented datasets and protein design tutorials have in common? These amazing researchers! At our first Megathon, participants worked all week long at a Data Bazaar and Tutorial Hackathon to create resources that can be used in the Rosetta Commons community and beyond. bit.ly/476wS2z

An image of the Padrãos does Descobrimentos (Monument to the Discoveries) sculpture in front of purple and orange lit clouds during sunset. The portion of the sculpture shown is primarily white colored and shows three men dressed in clothes from the late 15th century with the man in the front holding a model of a sailing ship. The text on the image says, “European RosettaCon, Lisbon, Portugal, Crossing Boundaries with Protein Design, Registrations are open, Early bird until 31st of May, 28th to 30th of October, 2026, NOVA University Lisbon, Campolide Campus, Rectory.” It has the Rosetta Commons logo at the bottom of the image in the middle.

European RosettaCon invites researchers in protein design, biomolecular dynamics, advanced microscopy, and structural determination methods to “cross boundaries in protein design” together. Join us to reach beyond traditional frontiers and into interdisciplinary approaches. europeanrosettacon.org

A flyer for Summer RosettaCon 2026. The top image shows a large group of people with their arms up standing on a cliffside with evergreen trees, a blue river, and hills covered in green trees in the distance, behind the group of people. There is the Rosetta Commons logo in the upper right, and some teal and orange hexagon structures in the corners. The bottom is a teal color with text that reads "Summer RosettaCon 2026, Frontiers in computational protein engineering: advances in AI, structural modeling, and design, August 3-7, 2026, University of Washington, Seattle, WA, Early bird registration ends March 31, rosettacon.org."

Computational protein modeling and design is a rapidly evolving field, with new emerging methods, tools, and applications. Each year the Rosetta community gathers to explore where the science is heading next by exchanging ideas and sharing new work at Summer RosettaCon. Register Today rosettacon.org

Science update:

Baker lab introduces NeoNectins, which help the body respond to surgical implants, healing gels, and other biomaterials. The study was led by postdoctoral scholar Xinru Wang, PhD, and visiting researcher Jordi Guillem-Marti, PhD

Quick read: rosettacommons.org/2025/06/26/d...

We'd like to thank our generous sponsors for making SRC 2025 a successful event. Your support fueled innovation, collaboration, and community.
Our sponsors this year: @vilyatx.bsky.social, Lila Biologics, Merck, NOVOPROTEIN, and @levitate.bio.
Explore these companies and their great work.

Introducing Deep-Learning–Designed Macrocycles: High-Affinity Protein-Binders Members of the IPD: Gaurav Bhardwaj, Frank DiMaio, and 2024 Nobel laureate David Baker have unveiled a deep-learning framework capable of the de novo design of macrocyclic peptides that bind protei…

Members of IPD: Gaurav Bhardwaj, Frank DiMaio, and 2024 Nobel laureate David Baker have unveiled a deep-learning framework capable of de novo design of macrocyclic peptides that bind proteins with nanomolar affinity and remarkable precision.
Read more: rosettacommons.org/2025/06/26/i...

Registration for the Biomolecular Modeling and Design with Rosetta and ML Tools Workshop (November 17–19, 2025) is now open. The goal of the workshop is to educate and train academic and industry users on the Rosetta software suite.

Explore more: meilerlab.org/tutorials/

We're excited to introduce our #RaMP 2025-2026 cohort. Watch this space for more updates.

It should be working now!

RFdiffusion: Beta Documentation Now Available

We’re excited to announce that RFdiffusion now has official, Rosetta Commons-curated documentation! Read more: rosettacommons.org/2025/07/16/r...

Release v1.0.0 · ajasja/prosculpt What's new Prosculpt now easier to install -- uses containers! Prosculpt now easier to run on SLURM -- all SLURM (queue, number of tasks) info can be given in the prosculpt yaml file. What's Chan...

We listened to your feedback. Proscuplt is:
*Easier to install - now uses use containers 🚀
*Easier to run in SLURM - specify queue & task details directly in the prosculpt YAML file.

github.com/ajasja/prosc...

Big thanks to Federico Olivieri, Alina Konstantinova, Nej Bizjak, and Žan Žnidar🙏

Looking Ahead: What’s Changing for RosettaCons in 2026 As the Rosetta Commons community continues to grow, the Executive Board has been actively rethinking how we plan and structure our annual gatherings. The goal is to create events that are more sust…

We’re making a few intentional changes to our US-based Rosetta conferences next year to better support our growing community. We want to hear what you think.

Learn more about the changes: rosettacommons.org/2025/06/26/l...

Share your thoughts: docs.google.com/forms/d/e/1F...

Rosetta Commons Opens Applications for 2025 Biosecurity Fellow Rosetta Commons is now accepting applications for our next Biosecurity Fellow! This unique 12-month fellowship offers the opportunity to work at the intersection of computational protein design and…

RC Biosecurity Fellowship is accepting proposals: 12-month program offers a chance to shape how protein design tools are developed & governed. Fellows lead initiatives, engage with our labs & policy experts, & help bridge science and policy around biosecurity.
rosettacommons.org/2025/06/26/r...

All about Prosculpt by Ajasja Ljubetic Prosculpt is an open-source library that encapsulates RFDiffusion, ProteinMPNN, AlphaFold2, and Rosetta into an easy-to-use workflow. The input is a yaml file describing the prob…

News from the Rosetta community: Prosculpt – an open-source library integrating RFDiffusion, ProteinMPNN, AlphaFold2 & Rosetta into one easy workflow

More via @ajasjaljubetic.bsky.social : rosettacommons.org/2025/05/28/a...

We are very excited to announce that early bird registration for European RosettaCon 2025 is now open!

More information here: europeanrosettacon.org

Members of EU Rosetta Con 2024

Early bird registration for 𝐄𝐔 𝐑𝐨𝐬𝐞𝐭𝐭𝐚 𝐂𝐨𝐧 𝟐𝟎𝟐𝟓 is open! 🎉🎉🎉

Come join us for three days of protein design fun! (October 20-22, 2025)

Direct registration link: pretix.eu/SBD/RCon2025/
Website: europeanrosettacon.org

We are looking forward to seeing you!

Please share this far and wide:)