Structures of the QatBC complex from Angela Gao and Doug Wassarman in our group reveal an evolutionary link between QatABCD and Type IV CBASS and a role for protein deazguanylation in diverse anti-phage defense systems

www.nature.com/articles/s41...

www.science.org/doi/10.1126/...

Agree - ComEC has been everybody’s nightmare (even for some of the genetics)…. thus, exciting to see the structure solved 🤩

Structural basis for DNA processing and membrane translocation by ComEC in natural transformation Natural transformation is one of the major pathways of horizontal gene transfer in bacteria, enabling the acquisition of extracellular DNA and its integration into the host genome. ComEC is a membrane...

ComEC structure is out!! 😍
Congratulations to the authors! That’s not an easy one. We have been trying for years to get that structure…
We failed and gave up.

Open Positions -

Open postdoc position in my lab on HGT and interbacterial competition. We seek candidates with a PhD in microbiology (or related fields)+ strong 1st-author publications.
Curious, highly motivated, and dedicated team players ready to contribute fully are encouraged to apply. Details: tiny.cc/cz01101

😱 Wow: Competence-mediated DNA uptake diversifies Vibrio cholerae sedentary chromosomal integrons:

👇

www.science.org/doi/10.1126/...

@science.org #vibrio

Now out in its final form! www.science.org/doi/10.1126/...

Diversity-generating retroelements for programmable targeted hypermutagenesis - Nature Biotechnology Diversity-generating retroelements are engineered for directed evolution in E.coli.

🔈Paper out! We turned the most fascinating phage host-switch mechanism, diversity-generating retroelements, into a programmable mutagenesis tool, DGRec. You can perform targeted hypermutation of any 50-200bp sequence directly in vivo in E. coli www.nature.com/articles/s41...

Finally published. Many thanks to a wonderful collaborative team and scientific platforms!!! And thanks to editors and reviewers for enthusiasm and a great review.

www.nature.com/articles/s41...

The type VI secretion system of Vibrio cholerae fosters horizontal gene transfer A water-borne pathogen seeks out and captures its neighbors’ genes.

Thanks Freddie🙏 🤩
You are not the first one telling me that the paper will be good for teaching 🤓
Unfortunately, no microscopy🔬 this time (in contrast to old T6SS paper).

The type VI secretion system of Vibrio cholerae fosters horizontal gene transfer | Science www.science.org/doi/10.1126/...

Now out in its final form in @jacs.acspublications.org: Reaction pathways & photoreaction yields of bifunctional lipid probes. The numbers that explain why we spend so much time optimizing protocols for cellular assays. 😉 pubs.acs.org/doi/10.1021/...

Thanks so much Dor - very kind of you 🙏.
Glad you enjoyed reading it 🤩

I really enjoyed reading this story. Congrats, Melanie!

Ilana Gabanyi is group leader at the Gulbenkian Institute for Molecular Medicine #Portugal. Learn how her EMBO Installation #Grant supported her transition from postdoctoral associate to young principal investigator: www.embo.org/people/a-new-home-for-th... 🧪 #opportunity

Amazing work from @fredoleroux.bsky.social lab - serious sampling w/ >1000 phages sequenced.
I love this paper❗So much new biology still to discover from this treasure box of phages +vibrios 🤓
Bin congrats to Freddie, Jeff, Karine et al + their collaborators @epcrocha.bsky.social & team 🎉👏

>1000 lytic vibriophages sequenced. 4 years later… still there. Same genomes. Same vibes. Different story. When nothing changes—but everything does. Congrats to Jeff & Karine et al. and @epcrocha.bsky.social for the intellectual turbulence ;-)
www.nature.com/articles/s41...

Congrats to Chase Morgan @phagemorgan.bsky.social and the phage team!

Excited to share the last installation of my PhD work. Worked with an all-star team on this one who really made this all come together beautifully. @ranidreamer.bsky.social @amardeeep.bsky.social @benadler.bsky.social and many others. www.cell.com/cell-reports...

Thanks a lot 🙏
We discontinued our Acinetobacter work but I could NEVER do research without Vibrio 😊

I miss Vibrio. This is absolutely fascinating science.

Thanks so much, Natália.
Hope all is well 🤩

Add-on: picture of the 3 technicians Laurie, Sandrine, Loriane & bioinformatician Alexandre, who carried out this work with me.
And what I almost forgot: sincere thanks to the three anonymous reviewers. Their constructive, fair feedback truly shaped the final manuscript-thank you, whoever you are 😉

Thanks so much, Seema 🙏 - very kind of you 🤩

Thanks Luiz - very kind of you 😀

Thanks so much Jesse 🤩

Thanks Luuk 🤩

We are recruiting postdocs to work on antimicrobial resistance and bacterial cell envelope biology. PLEASE SHARE.

...for the vibriologists #MicroSky

Thanks so much Tracy 😍

Such a lovely story 😊😊

Thanks Paul 🤩