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Believe it or not, but the complement system is really cool stuff once you get beyond the textbook knowledge

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Intracellular complement Factor H promotes tumor progression through modulation of cell cycle and actin cytoskeleton - Communications Biology Factor H overexpression predicts poor prognosis across cancers through cell-intrinsic effects. Intracellular FH in tumor cells and fibroblasts interacts with E2F/Rb, reduces nuclear p53, alters actin ...

💡New research reveals a cell‑intrinsic, pro‑tumorigenic role of Complement Factor H that extends far beyond its traditional extracellular complement activity.
www.nature.com/articles/s42...

The temporal gene expression landscape of rhabdomyolysis-induced acute kidney injury reveals the timing of complement activation

www.nature.com/articles/s42...

@roumenina.bsky.social

Factor H-related 1 and heparan sulfate architecture contribute to complement dysregulation in C3 glomerulopathy - PubMed Altogether, we show that as renal function declines, a change in the FHR-1:FH ratio combined with changes in heparan sulfate architecture increase complement activity. These findings suggest that…

Altered heparan sulphate architecture causes FHR-1 to disrupt FH function, increasing complement activation on mesangial cells. This is similar to how GAG changes in the blood/retinal barrier affect complement activity. #GAGs #FHRs #complement buff.ly/No5uT9h

Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation - PubMed Factor H (FH) is a negative regulator of the alternative pathway (AP) of complement however, five human factor H-related (FHR) proteins, can also function ex vivo as positive regulators. We compare…

Interesting to see that FHR proteins have now been found to accumulate in the synovial lining in rheumatoid arthritis, co-localising with C3. Study concluded that FHRs (mainly FHR3) may be driving complement activation. #complement #RA #FHRs buff.ly/b3hOgIX

« Nous sommes malheureusement encore loin des 80 % de couverture vaccinale… | Centre de Recherche des Cordeliers 🎙️ HPV : prévenir les cancers liés au papillomavirus, c’est possible – Agissons ! Des membres du Centre de Recherche des Cordeliers ont co-signé une tribune dans Le Monde, afin de rappeler l'urgen...

Prévenir les cancers liés au papillomavirus, c’est possible – Agissons !
Des membres du CRC ont co-signé une tribune dans @lemonde.fr, afin de rappeler l'urgence de la vaccination contre les #papillomavirus humains (HPV).
Agir tôt, c’est protéger durablement.

www.linkedin.com/feed/update/...

Congratulations @nicolasmerle.bsky.social !

Breaking Bruch's: How changes in Bruch's membrane influence retinal homeostasis - PubMed Breaking Bruch's: How changes in Bruch's membrane influence retinal homeostasis

Introducing our new review, "Breaking Bruch's: How changes in Bruch's membrane influence retinal homeostasis." It explores how the extracellular matrix (ECM) maintains cellular health and how its remodelling reveals genetic disease predispositions.

A great initiative for early career researchers in @crcordeliers.bsky.social
organized by @zucmanrossi.bsky.social and team!
I am excited about discussing with the participants on scientific communication and the use of social media.

Excited to share our review: Complement and the hallmarks of cancer - hot off the press in Seminars in Immunology!
Everything you ever wanted to know about #complementbiology and #cancer but never sared ask is here👇
authors.elsevier.com/sd/article/S...

Want to learn about the role of the complement system in the response to cytotoxic cancer therapy? Check out our latest review:

kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...