Differences in cells’ protein factories may help explain human diversity

Variation in the genes coding for RNA strands in ribosomes are associated with human traits, new research suggests.

Learn more: https://scim.ag/4vrvSR4

Great feature piece by @cofford.bsky.social in @science.org about our findings about rDNA sequence variation in the @ukbiobank.ac.uk and its association with body size traits. Don't miss it!!!

www.science.org/content/arti...

Thanks, Duncan!!

My lab and @smarino0111.bsky.social lab are currently looking for 2 PDRAs on a 3-year @bartscharity.bsky.social funded project. The posts will be based in Blizard Institute within Queen Mary Faculty of Medicine and Dentistry.
Check out the details and apply here: qmul-jobs.tal.net/vx/mobile-0/...

More acrocentric investigations, this one led by @arhie.bsky.social 🕵🏻‍♀️ “Biobank-scale genotyping of Robertsonian translocations reveals hidden structural variation on the human acrocentric chromosomes” 🧵[1/8]
📄 www.biorxiv.org/content/10.6...

Many thanks for all your guidance and support, Adam!!! 👏👏👏👏

Infinite thanks to @rakyanlab.bsky.social , @aphillippy.bsky.social, @mardakheh.bsky.social, @sergek.bsky.social and everyone else involved not yet around here (Elliott Whittaker Maia Cooper, Sasi Conte and Dave Evans) for making this happen!!! 🙌🙌

🚨 New Paper Alert!!! We continue exploring rDNA variation in the @ukbiobank.ac.uk and discover that the proportion of rDNA units harbouring specific sequence variants associates with human traits, particularly body size ones! Check it out 👇👇👇

New preprint from the lab! We dig into the regulatory roles of TEs in the mouse placenta, with some surprising findings. Led by the awesome @smamante.bsky.social. Particular kudos to him for navigating the many twists and turns of the project.

Data Scientist in Sutton | The Institute of Cancer Research View details and apply for this Data Scientist vacancy in Sutton. Salary : Salary range £39,805 - £53,500 (Salary appointment dependent on experience ) Reporting to: P...

Are you fascinated by cancer biology and also ❤️ 💻 ? Feel like this ->😻<- at the thought of exploring oodles of cancer genomes, single cells and spatial multiomics data? Then our core Data Science Team at @icr.ac.uk might be the place for you. Vacancy here: jobs.icr.ac.uk/vacancies/14...

A new test to predict which people with inflammatory bowel disease will get bowel cancer Dr Baker and Professor Graham are developing a non-invasive way to predict bowel cancer risk in people who have inflammatory bowel disease.

A big thank you to @bowelcanceruk.bsky.social and all their wonderful supporters for funding our research that aims to develop a blood test to predict bowel #cancer risk for people with inflammatory bowel disease #IBD. www.bowelcanceruk.org.uk/research/our... @icr.ac.uk

If you’ve heard me talk in the past ~5 years, you will know I have developed an obsession with acrocentric chromosomes. This is all of that, condensed into one paper. I will do a full thread in the new year, but for those that want something to read over the holidays, have at it. Such a cool story!

I was surprised to see A Natural History of Dragons by Marie Brennan was not mentioned!!! Obviously not technically speculative biology, but in some way speculating about how a dragon naturalist and her research would look like!

Postdoctoral Research Associate in Computational Muscle Biology at King's College London Apply for the Postdoctoral Research Associate in Computational Muscle Biology role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.

Final few days to apply for a postdoc pos. in our lab. If you have a passion for large data sets, data integration, sequencing and plenty of problem solving, then this could be for you!

Initial 12 months, but with a further 19months available for the right candidate!

www.jobs.ac.uk/job/DPK467/p...

Postdoctoral Research Associate in Computational Muscle Biology at King's College London Discover Postdoctoral Research Associate in Computational Muscle Biology jobs and more in higher education on jobs.ac.uk. Apply for further details on the top job board.

Please share far & wide. Looking for a #postdoc to get stuck in with a wide range of projects, with freedom to explore and lead the #computational #bioninformatics work

12 months to begin with, but for the right candidate we have funding for a further 19 months

www.jobs.ac.uk/job/DPK467/p...

Recruiting a comp PDRA for the lab 🚨

Working on multiple projects using integrated multi omics in bulk & single cell level

Passion for data, coding, bioinformatics & keen to lead our labs comp workflow

12 months in first instance but extendable for further 19 months

my.corehr.com/pls/coreport...

I had checked the README

i just hadn't reached the Glossary at the bottom (I had only seen the names in the function equivalents and I wrongly assumed that was the explanation you referred to).

It really doesn't 😅 still no idea what any of those words mean, although I assume yeet must have something to do with filter... somehow 🤷‍♂️

For someone who's not a parent of a teenager (nor live in the US, in case that's relevant), can someone explain why this is funny? 😶🤨 (no idea what bussin or yeep is supposed to mean, but I assume fr is "for real"?)

Specificity, length and luck drive gene rankings in association studies - Nature Genetic association tests prioritize candidate genes based on different criteria.

How do GWAS and rare variant burden tests rank gene signals?

In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!

🧬🧪🧵

www.nature.com/articles/s41...

Stained axons

@andreaserio.bsky.social and I are recruiting a postdoc to lead an exciting MNDA-funded project using multi-omics to study long axons in motor neurons and how they shape susceptibility to #ALS.

Get in touch for any questions and apply by 2 December:
my.corehr.com/pls/kclrecru...

Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database - Nature Communications Here the authors provide an explanation for 95% of examined predicted loss of function variants found in disease-associated haploinsufficient genes in the Genome Aggregation Database (gnomAD),…

New study of 800K+ genomes from gnomAD reveals most “pathogenic” variants in healthy people aren’t truly disease-tolerant. They are explained by annotation errors, mosaicism, or compensatory variants. 🧬
A big step for precision medicine!
www.nature.com/articles/s41...

We will soon be looking for a comp biologist or bioinformatician to work on a number of linked projects within the lab - main focus is on molecular control of muscle

Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!

Together with Chris Bell and Alexander Dawson, we are recruiting an PhD student (LIDo iCASE) at @qmulepigenetics.bsky.social to work on using long read nanopore technology to investigate DNA methylation on native DNA. This is a joint project with ONT. www.findaphd.com/phds/project...

The brain-muscle epigenetic interplay in neuromuscular disease - MRC DTP Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease marked by progressive motor neuron loss. Emerging evidence suggests a critical, previously underappreciated role for skeletal muscle in ALS onset and progression, highlighting pathological and molecular interplay between brain and muscle. However, systematic, high-resolution molecular analyses across these tissues remain scarce. This project will use advanced […]

🚨Second position available in the lab.

Through MRC DTP programme we have a PhD opportunity working on brain-muscle axis, analysing shared/divergent molecular signatures across bulk tissue and single cell.

Please spread the word!

kcl-mrcdtp.com/project/the-...

Postdoctoral Research Associate in Muscle Biology and Genomics | King's College London

🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important

Good collab with @droch.bsky.social so travel to CPH involved as well

www.kcl.ac.uk/jobs/126245-...

Yup, I can access that way

Still getting "access denied", unfortunately

Amazing news, Alex!!! Well done!!!! 🙌🙌

Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis Transcription of ribosomal RNAs (rRNAs) from rDNA repeats is the first step of ribosome biogenesis, accounting for a major portion of all cellular transcription. Often regarded as a housekeeping proce...

📣 New preprint 📣

We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.

Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)