Out now–our work on bacterial cGAS-like enzymes making 2′,3′-cGAMP! Read Uday's thread for updates since the preprint including determining our lab's first protein structure and developing a new system to study bacterial STING homologs in phage defense👇

@nitzantal.bsky.social @romihadary.bsky.social @soreklab.bsky.social use structure prediction and in silico binding site analysis to discover viral immune evasion proteins! Exciting for our lab @reneechang.bsky.social @riveralopz.bsky.social to help with this project.
www.science.org/doi/10.1126/...

Cell death is a fundamental mechanism of antiviral immunity across diverse organisms, including bacteria. As my final PhD project with @jbdsf.bsky.social, I was curious whether cell death is required for successful immunity with the ancient cGAS pathway known as ‘CBASS.’

Spoiler – the answer is no!