Don't be shy to take on a little two-week side project. These five months will be the most precious three years of your academic journey.

This essay affected me deeply.

“Emotional depletion becomes nor-malized. Fatigue becomes proof of commitment. Delayed gratification becomes professional identity.
There is nobility in that commit-ment, but endurance has a quiet cost….And steady depletion follows us home.”

As I said: 8 hours :)

Annette Dolphin obituary Other lives: Neuroscientist whose research showed how individual molecules can affect neurological disorders

Obituary of Annette Dolphin @annieneuro.bsky.social written by her sister in The Guardian. www.theguardian.com/science/2026...

Figure 2. FORCE1s reports in vivo neuronal activity with high fidelity under resonance scanning 2-photon microscopy (A-I) 2P-guided whole-cell patching and resonant-scan imaging in anesthetized mice. (A) Experimental schematic. (B) 2P images of a representative FORCE1s-Kv-expressing neuron are shown at high resolution (i) and the size and resolution used during voltage imaging (ii). The patching pipette is outlined. (C) Simultaneous electrophysiological recording (top, 10 kHz) and FORCE1s-Kv fluorescence imaging (bottom, 440 Hz). The fluorescence trace was low-pass filtered at 150 Hz to enhance the visualization of the spikes. Dashed boxes: epochs shown in panels D-E. Vertical lines: detected spikes. Gray triangle (left, and in panels D-E): -70 mV. (D-E) Zoomed-in subthreshold (D) and bursting (E) epochs. Panel D’s optical trace was low-pass filtered at 50 Hz to enhance the visualization of subthreshold fluctuations.

This is beautiful data. 2p optical reporting of subthreshold voltage, validated with simultaneous patch clamp. www.biorxiv.org/content/10.6... FORCE1s by François St-Pierre's group, with a bunch of great people joining in.

On April 19, 1898, Camillo Golgi first described what we now call the Golgi apparatus - a structure so striking and unusual that it took more than 50 years for scientists to accept it wasn’t just an artefact.

April 19 is #GolgiDay! Celebrate the cell’s most iconic and best organelle.

Yes, I kinda knew!

Fully documented source code for Elite on the 6502 (BBC Micro, Acorn Electron, Commodore 64, Apple II, NES) Fully documented source code for Elite on the 6502 (BBC Micro, Acorn Electron, Commodore 64, Apple II, NES), with more than 100 deep dive articles explaining how every aspect of this iconic game works...

Someone has documented the entire source code for Elite and explained how every line works, plus included deep dives into various functionality. Covers all main versions like BBC Micro, Commodore 64 and NES. You can also play online in browser. elite.bbcelite.com

Brought some compact discs up from the archive. Which one would you put in first?

Sadly, applications to the Advanced Python summer school have dropped significantly over the past 2 years.

Plus, there'll be no external funding for the 1st time in *17 years*.

Likely all because of GenAI - but programming skills still matter🔥

Deadline May 3, please help by sharing:
aspp.school

the median number of authors on a research paper who are familiar with the underlying code: 1

it generally feels like that number will decrease even further, honestly a quite scary development. 😕⬇️

Great news!

About double the energy density of conventional batteries, AFAIK.

Happy #FluorescenceFriday!

It would make sense that they now have more grades. Like A means come back next year, B in 2 years, C in 3, D in 4 etc.

I can imagine that the new ABC grades (of next year, in 3 years, or 4 years) doesn't fully reflect what the panels intended. Very harsh on any Bs from the invited top 44!

#ERC

Hmmm, affects me as my AdG 2025 proposal got a “B” 🫠 , but what can they do? They can’t keep up with demand which has skyrocketed.

In France, if you want to build a home above a certain size, you’re legally required to use a licensed architect.

Can you guess what that size is

Makroaufnahme: Ein Trauerrosenkäfer (Oxythyrea funesta), völlig bedeckt mit Blütenstaub sitzt im Zentrum einer weißgelben noch nicht ganz geöffneten Tulpe. Das Bild ist genau von oben in die Tulpe hineinfotografiert.

Robert Rosenkäfer wohnt in Tulpenhausnummer 12 und ist gerade mit dem Hausputz beschäftigt.😁 Guten Morgen, Bluesky-Bande!

UK and EU finalise agreement to bring UK into Erasmus+ in 2027 Thousands across the UK set to benefit from re-opening of the historic Erasmus+ programme

The UK rejoining Erasmus is the best science news for a while! #AcademicSky

www.gov.uk/government/n...

Amazing find by @oliverrocks.bsky.social and @pm-mueller.bsky.social , such a cool discovery. Was fun to be involved.

#password

An unpopular but correct view, I believe. Hold on!

Steamed Hams full transcript Well, Seymour, I made it- despite your directions. Ah. Superintendent Chalmers. Welcome. - I hope you're prepared for an unforgettable luncheon. - Yeah. Oh, egads! My roast is ruined. But what if I were to purchase fast food and disguise it as my own cooking? Delightfully devilish, Seymour. Ah- Skinner with his crazy explanations The superintendent's gonna need his medication When he hears Skinner's lame exaggerations There'll be trouble in town tonight Seymour! Superintendent, I was just- uh, just stretching my calves on the windowsill. Isometric exercise. Care to join me? Why is there smoke coming out of your oven, Seymour? Uh- Oh. That isn't smoke. It's steam. Steam from the steamed clams we're having. Mmm. Steamed clams. Whew. Superintendent, I hope you're ready for mouthwatering hamburgers. I thought we were having steamed clams. D'oh, no. I said steamed hams. That's what I call hamburgers. You call hamburgers steamed hams? Yes. It's a regional dialect. - Uh-huh. Uh, what region? - Uh, upstate New York. Really. Well, I'm from Utica, and I've never heard anyone use the phrase "steamed hams. " Oh, not in Utica. No. It's an Albany expression. I see. You know, these hamburgers are quite similar to the ones they have at Krusty Burger. Oh, no. Patented Skinner burgers. Old family recipe. - For steamed hams. - Yes. Yes. And you call them steamed hams despite the fact that they are obviously grilled. Ye- You know, the- One thing I should- - Excuse me for one second. - Of course. Well, that was wonderful. A good time was had by all. I'm pooped. Yes. I should be- Good Lord! What is happening in there? - Aurora borealis. - Uh- Aurora borealis at this time of year at this time of day in this part of the country localized entirely within your kitchen? - Yes. - May I see it? No. Seymour. ! The house is on fire. ! No, Mother. It's just the northern lights. Well, Seymour, you are an odd fellow but I must say you steam a good ham.

Today is officially the 30th anniversary of Steamed Hams. On April 14, 1996, "22 Short Films About Springfield" aired for the first time!

Another example of the brain being bigger in the inside than it is outside.

It’s a Tardis.

RORY!

HOW have I never seen Total Recall until now?

Instantly my favourite Verhoeven film!

I sent ChatGPT some 💩 2D classes and this is what it said... similar energy 😅🫠

The topic of Mr. Back’s Ph.D. thesis, he told me, was distributed computer systems: Programs that rely on a web of independent computers known in computer parlance as “nodes” to work together to run their software. This was another technological pillar of Bitcoin. And Mr. Back’s thesis project focused on C++ — the same programming language Satoshi used to code the first version of the Bitcoin software.

I am hyperventilating, Dan Brown's Digital Fortress is better than this.

NODES. AND C++.

"I was convinced I had made a horrifying discovery. Not only was Mr. Back behind Bitcoin, but possibly all software on the Internet as we know it. It was time to bring in my whiteboard and some game theory."

RegioJet končí v Polsku. Peklo, které ohrožuje naši firmu, vysvětluje Jančura - Zdopravy.cz Dopravce tvrdě zkritizoval neférové podmínky na polském trhu.

Important 🇪🇺 rail news

🇨🇿 private operator RegioJet is pulling out of Poland on 3 May, not even a year after entering the market there

Run this through machine translation:
zdopravy.cz/regiojet-konci-v-polsku-...

View back up the valley.

Austrian Alps, Gastein, from the train.

Dorfgastein, Austria. From the train.