Can generative AI accelerate neuroscience? Excited to share MoGen at ICLR 2026!🧠
We use point cloud flow matching to generate high-fidelity 3D neuron fragments, capturing intricate details like dendritic spines.
This work was a collaborative effort between our lab and clinical experts at UPK Basel. The parallel approach of using mouse circuit and human patient data is likely the most promising approach we have to understanding the mechanism of psychiatric treatments.
Full paper:
doi.org/10.64898/202...
New preprint with @sevberg.bsky.social! We map Hopfield-like binary networks onto spiking networks with dendrites … and it works! Same memory capacity, bigger basins of attraction, plus selective recall through dendritic gating, and more. How? Dendrites! See below.
Great opportunity to shape the future of X-ray connectomics (and much more 😉):
@psi.ch is looking for a new head of the Center for Photon Science
www.psi.ch/en/hr/job-op...
#paper:
Drying tissue samples enhances contrast in X-ray phase contrast imaging while largely preserving ultrastructure. 🧠🔬
doi.org/10.1107/S160...
@safekhan.bsky.social @andreas-t-schaefer.bsky.social
@crick.ac.uk @embl.org @imperialcollegeldn.bsky.social @esrf.fr @uclnpp.bsky.social
“We’re hoping doors will open for researchers to ask questions about how connections are made in the brain in mice and maybe, one day, humans.” - @andreas-t-schaefer.bsky.social
Read about the new NIH-funded program to map brain circuitry using X-rays: www.crick.ac.uk/news/2026-03...
Exciting new results from our neighbors in the @mace-lab.bsky.social! Using functional ultrasound imaging, they look at brain-wide activity patterns in response to arousing events, showing propagation from subcortical regions to the cortex, and find a surprisingly weak modulation by noradrenaline!
How do fish localize sound without interaural cues? @johve.bsky.social et al. found a behavioral algorithm for directional hearing that predicts behavior from a pressure/motion phase comparison and accounts for how this relationship varies with distance. www.cell.com/current-biol...
Job alert!
Join the Making Lab at the @crick.ac.uk.
As a senior engineer in system design, programming, and hardware–software integration, you'll develop systems that make unique experiments possible.
More about the role and apply here: crick.wd3.myworkdayjobs.com/External/job...
From @bdpedigo.bsky.social: a super efficient, highly reliable, and very generalizable method for mesh structure classification, applied here to spine detection across basically every synapse onto a cell in the MICRoNS dataset.
Four diverse individuals honored as winners of the 24th annual Wiley Prize in Biomedical Sciences.
The Wiley Foundation is pleased to announce the winners of the 24th annual Wiley Prize in Biomedical Sciences, which recognizes contributions that open new fields of research or advance concepts in a particular biomedical discipline.
Learn more: https://ow.ly/ZaiM50YhCF6
In @eLife: Neural connectome of the ctenophore statocyst https://doi.org/10.7554/eLife.108420
Version of record of our ctenophore nerve-net connectome paper.
What it's like to be a connectome
The winner of the 2026 Pradel Research Award is H. Sebastian Seung of @princetonneuro.bsky.social! He is being honored for for transformative advances in computational neuroscience. Learn more about his discoveries: www.nasonline.org/award/pradel... #NASaward #neuroscience
What's the relation between voltage and calcium in dendrites? Xiang Wu studied this in CA2 hippocampal pyramidal cells in behaving mice. www.biorxiv.org/content/10.6...
🔬🔦Our latest ‘Imaging spotlight’, by @carlesbosch.bsky.social, Ana Diaz, @adrianawanner.bsky.social & @andreas-t-schaefer.bsky.social, highlights the non-destructive X-ray tomography pipeline that the authors developed to map mouse brain ultrastructure & considers future applications & developments.
Poster of the EM course in Naples with marine samples. The Electron Microscopy Hands-On Course: sample preparation and imaging of marine environmental samples arises from a very strong and active collaboration between the Stazione Zoologica Anton Dohrn and the EMBL in Heidelberg. The aim of the course is to provide a theoretical and practical training on electron microscopy starting from the basics to the preparation of samples with high pressure freezing and image acquisition using TEM and SEM.
If you are interested in electron microscopy, registration is still open for the
"Electron Microscopy Hands-On Course: sample preparation and imaging of marine environmental samples"
at Stazione Zoologica in Naples.
WIth great teachers from Naples […]
[Original post on biologists.social]
Two nerve nets are formed in Hydra vulgaris: the endodermal (cyan) and the ectodermal (purple) net. (B) Intraepithelial neurons are randomly scattered between the epithelial cells of the two germ layers. (C) Two types of connections have been found between Hydra’s neurons. (D) Endodermal neurons are in physical touch with each other by forming neural handshakes by digiform endings, which get intertwined. (E) In other places, clusters of vesicles of different types can be released to mediate volume transmission between neurons and between neurons and other cells.
Our dispatch:
www.sciencedirect.com/science/article/pii/S096...
on the recent Hydra volume EM paper by Zhang, Rafa Yuste and colleagues:
#connectomics, without synapses
www.sciencedirect.com/science/article/pii/S096...
#neuroscience
A paper from my PhD lab is on Science! This is a really cool new way to utilize EM connectome datasets. Congrats to the team!
www.science.org/doi/10.1126/...
How do neural circuits generate the walking rhythm?
Using connectome simulations, @sarahpugly.bsky.social found a minimal central pattern generator (CPG) that produces oscillations in leg motor neurons. Same circuit motif for each 🪰 leg.
w @bingbrunton.bsky.social
www.biorxiv.org/content/10.1...
Last night Adam Kampff, the glue, the light, the catalyst, the builder, the smile, left us. He and his work transformed the lives of many labs, scientists, students. He inspired and was generous to his last transformation, working tirelessly to set up a foundation to continue the work.Thank you!
Our Method of the Year 2025 is...drumroll please...EM-based connectomics!!
Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬
www.nature.com/articles/s41...
Connectomics is Method of the Year 2025!!
@natmethods.nature.com
just released the news nature.com/articles/s41... In my perspective piece, I afford some predictions into the future and compare how we are doing vs. genomics www.nature.com/articles/s41...
An optimized X-ray nanotomography method offers an attractive alternative to volume EM for connectomics. @crick.ac.uk @psich.bsky.social psich.bsky.social @adrianawanner.bsky.social @andreas-t-schaefer.bsky.social @ucl.ac.uk @uclnpp.bsky.social
www.nature.com/articles/s41...
Very cool, congrats!
Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41...
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
This work was generously supported by a SERI-funded ERCStG @sbfi.admin.ch @erc.europa.eu
#paper!
X-rays can resolve #ultrastructure in tissues non-destructively.
www.nature.com/articles/s41...
Shoutout to key collaborators at @crick.ac.uk and @psich.bsky.social Ana Diaz, @adrianawanner.bsky.social and @andreas-t-schaefer.bsky.social, and to the whole team that made this possible.
By repurposing a radiation-hard epoxy resin from the nuclear/aerospace industry, we made samples withstand >1.15×10¹⁰ Gy and reached sub-40 nm resolution, revealing axons, dendrites, mitochondria and synapses without sectioning.
