Many thanks to funders including @cancerresearchuk.org @bloodcanceruk.bsky.social @cclguk.bsky.social
and The Howat Foundation that supported this work.

Many thanks and congratulations to Katerina Himonas
for driving this work.

For those who are interested in using CSFmax in their research, the bespoke medium will be available at cancertools.org/cell-culture...

In this work we describe the development of new cell culture medium (CSFmax) that recapitulates the unique metabolite composition of the cerebrospinal fluid (CSF).

We also reveal that autophagy in critical for metabolic adaptation and survival of CNS-resident ALL cells.

Delighted to share our manuscript "Physiological cerebrospinal fluid like medium reveals autophagy dependency of leukaemia in the central nervous system"

Great collaborative team effort with @chrishalsey.bsky.social and Saverio Tardito

www.biorxiv.org/content/10.6...

A metabolism-specific drug-repurposing screen reveals itraconazole as a potent OXPHOS inhibitor in acute myeloid leukemia Key Points. Nutrient sensing drug-repurposing screen identifies itraconazole, an FDA-approved azole antifungal, as a mitochondrial metabolism inhibitorItra

Hot off the press from @helgasonlab.bsky.social ashpublications.org/blood/articl...

Thanks to all the local colleagues at
@uofgcancersciences.bsky.social @glasgow.ac.uk @cruk-si.bsky.social and international collaborators who played an essential role in this work!

And many thanks to funders including
@bloodcanceruk.bsky.social and @cancerresearchuk.org

#BloodCancerResearch

A metabolism-specific drug-repurposing screen reveals itraconazole as a potent OXPHOS inhibitor in acute myeloid leukemia Key Points. Nutrient sensing drug-repurposing screen identifies itraconazole, an FDA-approved azole antifungal, as a mitochondrial metabolism inhibitorItra

Delighted to share our publication in
@bloodjournal.bsky.social where we describe the identification of antifungal itraconazole as a potent inhibitor of mitochondrial metabolism in AML

Great effort by joint first authors Katerina Himonas and Lucie de Beauchamp.

ashpublications.org/blood/articl...

Happy holidays from the Helgason Lab. Wishing everyone has a wonderful festive break 🎄🎅🤶

Research is never a solo effort.
It takes teamwork. It takes belief. It takes collaboration across disciplines, institutions, and communities.
We know what it takes to beat blood cancer.
#BloodCancerAwarenessMonth

Located at the Wolfson Wohl Cancer Research Centre and CRUK Scotland Institute, in Glasgow.

Supervisory team: @helgasonlab.bsky.social Daniel Murphy, Peter Hall, Kevin Blyth, Bodhayan Prasad

Deadline: 30th June

CRUK Scotland Centre - Investigating Asbestos exposure and other environmental factors underpinning Lung cancer inequalities in the Scottish population at University of Glasgow on FindAPhD.com PhD Project - CRUK Scotland Centre - Investigating Asbestos exposure and other environmental factors underpinning Lung cancer inequalities in the Scottish population at University of Glasgow, listed o...

PhD opportunity (open to UK-Students only):

Interested in PhD project where you investigate environmental factors driving lung cancer inequalities?

The project allows you to learn computational and lab experimental approaches

Deadline: 30th June

Please share!
www.findaphd.com/phds/project...

Networking…

Great trip to Iceland for this year’s Lab Retreat. Stimulating science discussion at the University of Iceland, followed by networking and some sightseeing 🚐 🌬️🌈 🇮🇸
Team and landscape photos below 👇👇👇

Fantastic Martha - congrats again!!!

We are looking for a Research Associate to join the Mitochondrial Oncogenetics (@mito-oncogene.bsky.social) lab and investigate the impact of mitochondrial DNA on tumour microenvironments

📅Closing date: 7 February 2025

👉Find out more and apply here: www.crukscotlandinstitute.ac.uk/careers/scie...

Research Assistant/Associate Position in the lab. Fully funded until February 2028. Please apply if you are passionate about inter-organ signalling and intestinal biology...And off course, our wonderful Drosophila!

Position details and application link below

www.jobs.gla.ac.uk/job/research...

Save the date!
Hope to see you in Dundee in June.

We hope all friends and colleagues will have a well deserved break during the festive season 🎄
We certainly had fun during our Western themed Christmas lunch 🤠