Unraveling the Dynamics of Oxytocin in Hypothalamic Neurons Oxytocin (OT) plays an important role in regulating social behavior, and dysregulation of the oxytocinergic system leads to social impairments, such as autism spectrum disorder. Central OT release is...

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KIF5B and Dynein‐Dependent Golgi Organization: Role in Adhesion‐Dependent Microtubule Acetylation KIF5B and dynein regulate Golgi organization and localization- Role in regulating MT acetylation: In control (CNT) cells, active Arf1 facilitates the recruitment of KIF5B and dynein to the Golgi, mai....

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Protein Kinase D Regulates Kinesin‐Mediated VEGFR2 Trafficking and Influences Retinal Endothelial Permeability Upon VEGF binding, VEGFR2 is autophosphorylated and recruits downstream signaling molecules, leading to protein kinase D (PKD)1 phosphorylation. We found that PKD1 phosphorylates KIF13B, a kinesin-3 ...

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Palmitoyl Acyltransferases Control the Membrane Localization of DNAJC5 to Regulate Unconventional Protein Secretion Acylation of DNAJC5 by PAT facilitates its association with the Golgi apparatus, enhancing the secretion of abnormal cytosolic proteins via unconventional protein secretion.

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Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule-dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential phys...

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Clathrins Are Involved in the Endocytosis of Host Cytosol in the Malaria Parasite This study characterized clathrin function in hemoglobin uptake from host red blood cells via the malaria parasite's specific endocytosis machinery, cytostome. Clathrin heavy chain, clathrin light ch...

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Copper Homeostasis at the Crossroads of Cellular Metabolism, Epigenetic Regulation and Protein Trafficking Copper homeostasis is maintained in the cell by epigenetic regulation, and various metabolic processes. Regulated copper homeostasis balances normal protein trafficking, amino acid metabolism, etc., ...

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The Role of Small Extracellular Vesicles in Tumor Development and the Prospect of Targeted Therapy Mechanisms of sEV uptake:① Membrane fusion.② Endocytosis.③ Receptor-ligand interaction.

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Beyond the Secretory Pathway: New Insights Into Protein Release While proteins bearing N-terminal signal or leader sequences are secreted via the ER-Golgi-plasma membrane axis of the conventional secretion pathway, many cytosolic proteins lacking signaling sequen...

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Virion Associated Importin Subunit Beta‐1 Augments Nuclear Import of HIV‐1 Pre‐Integration Complex - Yandrapally - 2025 - Traffic - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...

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Spatiotemporal Analysis of Glucagon Secretory Granule Dynamics - Ghignoli - 2025 - Traffic - Wiley Online Library onlinelibrary.wiley.com/doi/abs/10.1...

Strain‐Dependent Immune Signaling by Small Extracellular Vesicles Derived From Trypanosoma cruzi‐Infected Macrophages Chagas disease, caused by Trypanosoma cruzi, remains a major treatment challenge due to variations in host immunity and parasite strains. We found that small extracellular vesicles (EVs) from infecte...

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From Mechanisms to Therapy: Exploring the Role of Ferroptosis in Cervical Cancer Transformation and Treatment This review mainly discusses the role of ferroptosis in cervical cancer from four aspects: underlying mechanisms, stage-specific sensitivity, ferroptosis-related targets and biomarkers, and clinical ...

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Editors Choice Articles: Traffic Traffic is a cell biology and biochemistry journal devoted to intracellular transport, covering subcellular trafficking, membrane dynamics, organelle function & more.

Editor's selected articles of the last two years onlinelibrary.wiley.com/doi/toc/10.1...

Traffic Traffic is a cell biology and biochemistry journal devoted to intracellular transport, covering subcellular trafficking, membrane dynamics, organelle function & more.

onlinelibrary.wiley.com/journal/1600... Traffic is a cell biology and biochemistry journal devoted to intracellular transport in health and disease, covering disciplines such as developmental biology, neuroscience, immunology, and infection in eukaryotes.

FGF Signaling Promotes Lysosome Biogenesis in Chondrocytes via the Mannose Phosphate Receptor Pathway FGF signaling regulates lysosomal homeostasis in RCS chondrocytes by inducing TFEB/TFE3 nuclear translocation and activation. This promotes the expression of lysosomal genes and mannose 6-phosphate r....

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CIN85 and CD2AP Are Novel Constituents of Dynamic Tubular Recycling Endosomes That Regulate Recycling Upon Recruitment by MICAL‐L1 In this study, we characterize tubular recycling endosomes and demonstrate that they are dynamic and undergo biogenesis upon CD98 internalization and fission over time. We identify CD2AP and CIN85 as...

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Eukaryote‐Wide Distribution of a Family of Longin Domain‐Containing GAP Complexes for Small GTPases The three longin domain-containing GAP complexes - CSW, folliculin, and GATOR1 - have a sporadic but pan-eukaryotic distribution and were likely already present in LECA in some form. Their catalytic ...

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✍️ The Jackson/Verbavatz Lab contributed to the publication of a new article
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📃 Eukaryote-Wide Distribution of a Family of Longin Domain-Containing GAP Complexes for Small GTPases
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Traffic has two calls for papers running: on #clathrin to to celebrate the 50th anniversary of its discovery and #UPS #unconventionalproteinsecretion onlinelibrary.wiley.com/page/journal...

Traffic has two calls for papers running: on #clathrin to to celebrate the 50th anniversary of its discovery and #UPS #unconventionalproteinsecretion onlinelibrary.wiley.com/page/journal...

Salmonella Typhimurium Manipulates Syntaxin 7 to Navigate Endo‐Lysosomal Trafficking in Host Cells Salmonella Typhimurium hijacks the host Qa-SNARE syntaxin 7 (STX7) to manipulate endo-lysosomal trafficking and sustain intracellular survival. STX7 displays cell–type–specific expression and localis...

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TENT5/FAM46: An Enigmatic Family of Secretory Tuners TENT5s multifaceted roles in key biological processes and human diseases. TENT5 is a family of four proteins (TENT5A–D) with tissue-specific functions influencing tumor proliferation, fertility, bone....

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A Sensitive and Versatile Cell‐Based Assay Combines Luminescence and Trapping Approaches to Monitor Unconventional Protein Secretion In this study, Denus et al. develop a powerful and highly customizable split luciferase-based assay allowing the analysis of multiple cargo proteins released by unconventional protein secretion. This...

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BicD and MAP7 Collaborate to Activate Homodimeric Drosophila Kinesin‐1 by Complementary Mechanisms Kinesin-1 is auto-inhibited and binds microtubules weakly. Binding of kinesin-1 to the adaptor protein BicD enhances processive motion, while the microtubule-associated protein MAP7 recruits more kin....

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TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells Epithelial-immune cell crosstalk is tightly regulated by secretion of immune cell mediators into luminal and serosal fluid spaces of epithelial tissues. We report two major new findings regarding how...

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Golgi Localized Arl15 Regulates Cargo Transport and Cell Adhesion The model illustrates the function of Arl15 in vesicular transport and cell surface organization. Arl15 localizes majorly to the Golgi and plasma membrane (PM), which is primarily dependent on Arf1-d...

Just Published: Golgi Localized Arl15 Regulates Cargo Transport and Cell Adhesion
Prerna Sharma, Pooja Hoovina Venkatesh, Shalini Samal, Neha Paddillaya, Nikita Shah, B. R. Rajeshwari, Abhay Bhat, Deepak Kumar Nayak, Archishman Dakua, Aravind Penmatsa …
doi.org/10.1111/tra....

Re‐Visiting the Intracellular Pathway of Transferrin on Board of a Mathematical Simulation The transport of transferrin is among the most extensively studied trafficking processes. In this commentary, we utilize a mathematical simulation of the endomembrane system to revisit transferrin tr...

Just Published: Re-Visiting the Intracellular Pathway of Transferrin on Board of a Mathematical Simulation
Franco Nieto, Luis S. Mayorga
doi.org/10.1111/tra....

Just Published: Golgi Localized Arl15 Regulates Cargo Transport and Cell Adhesion
Prerna Sharma, Pooja Hoovina Venkatesh, Shalini Samal, Neha Paddillaya, Nikita Shah, B. R. Rajeshwari, Abhay Bhat, Deepak Kumar Nayak, Archishman Dakua, Aravind Penmatsa … See all authors
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