Richard thanks for your work. Read about the two species of RCT here and the third layer estimand in this preprint. This is part of a trilogy of papers exploring modern RCT structure which contributed to the pandemic ventilator guideline failure.
zenodo.org/records/1958...
Ed this is the third in a series of articles relating to RCT structure. This one presents the third estimand, and the “cause-mixture paradox”.
It discusses the emergence of “synthetic data generating processes” (SDGPs) in critical care and elsewhere.
zenodo.org/records/1958...
It’s hard to correctly state the contribution Richard has made to statistical education. He’s made the subject come alive for so many students (myself included) and continues to iterate and improve on what is already wonderful pedagogy: all for free. An inspiration to educators everywhere. 🤩🙏🎓
Yet they keep doing these synthetic syndrome RCT.
Read about the “third estimand”in this preprint, the third in the “RCT structure trilogy”. Every crit care doc should learn to do basic structural RCT analysis.
zenodo.org/records/1958...
Yeah and if you didn’t like him wait till you read the “RCT structure trilogy” about “synthetic data generating processes” (SDGPs) and the ecosystem that creates and studies them.
zenodo.org/records/1958...
That’s not enough for crit care syndrome RCT. Here there is a “third layer estimand” causing the “cause-mixture paradox” as in REMAP CAP and decades of CS for CAP RCT & 3+ decades sepsis & ARDS RCT
Why do they reverse? Study the 3rd Layer!
E3 = sum(i)_pi¡(S = 1)E2(i)
zenodo.org/records/1958...
Preprint in review (third of the RCT structural series). This examines the 3 layer structure of RCT of crit care syndromes.
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Lynn’s Paradox
“A phenomenon in which sequential cause-agnostic randomized trials (CARs) testing a treatment for a disease-agnostic syndrome yield opposing conclusions across studies because enrolled participants represent a shifting mixture of diseases with opposing treatment effects.”
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The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
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The danger to the public of using syndromic entry criteria for RCT in critical care.
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The danger to the public of using syndromic entry criteria for RCT in critical care.
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The danger to the public of using syndromic entry criteria for RCT in critical care.
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The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
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The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
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The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
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The danger to the public of using syndromic entry criteria for RCT in critical care.
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The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
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The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
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The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
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The danger to the public of using syndromic entry criteria for RCT in critical care.
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The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
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The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
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The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
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The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
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The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
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The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
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The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...