Psilocybin restores behavioral and neuroplastic deficits induced by chronic stress in rats Psychedelics have emerged as a promising novel therapeutic approach for major depressive disorder (MDD). Altered activity and structural atrophy of th…

Psilocybin restores behavioral and neuroplastic deficits induced by chronic stress in rats
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From uniform pharmacotherapy to precision psychiatry: reinforcement sensitivity associations with SSRI outcomes - Psychopharmacology Psychopharmacology - Selective serotonin reuptake inhibitors remain the first-line pharmacotherapy for depression and anxiety disorders, yet remission rates are low and variability in treatment...

From uniform pharmacotherapy to precision psychiatry: reinforcement sensitivity associations with SSRI outcomes
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Cannabidiol at the crossroads: panacea, placebo, or problem? - Neuropsychopharmacology Neuropsychopharmacology - Cannabidiol at the crossroads: panacea, placebo, or problem?

Cannabidiol at the crossroads: panacea, placebo, or problem?
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Cannabinoid Modulation of Emotion, Memory, and Motivation Covers the role of the endocannabinoid system in the regulation of emotional processes with emphasis on memory and the motivational aspects in cannabis use

Cannabinoid Modulation of Emotion, Memory, and Motivation
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Defining the concept of psychological trauma
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Sex effects on gene expression across the human cerebral cortex at cell type resolution
www.science.org/doi/10.1126/...

14 things our PhD supervisors got right and why it mattered PhD students reflect on how their supervisors made a meaningful difference — from quiet acts of kindness to career-shaping guidance.

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Rational design of Gi-biased CB1 agonist with reduced side effects Rational design of cannabinoid receptor agonists that uncouple therapeutic analgesia from unwanted on-target effects, establishing a blueprint for next-generation non-opioid therapeutics.

Rational design of Gi-biased CB1 agonist with reduced side effects
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Remodeling synaptic connections via engineered neuron-astrocyte interactions - Nature Communications Modulating synaptic connections remains challenging. Here, the authors show that SynTrogo (Synthetic Trogocytos) is a synthetic astrocyte-neuron interaction system, and reduces synaptic connectivity, ...

Remodeling synaptic connections via engineered neuron-astrocyte interactions
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Semantic encoding of trauma memories in the hippocampus among individuals with PTSD - Neuropsychopharmacology Neuropsychopharmacology - Semantic encoding of trauma memories in the hippocampus among individuals with PTSD

Semantic encoding of trauma memories in the hippocampus among individuals with PTSD
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MICRODOSING: FACT OR FICTION?

Microdoing: Fact or Fiction?
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Chronic stress enhances threat responding and impacts fear extinction
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Neurobiology of Posttraumatic Stress Disorder: Circuits, Genomics, and Treatment Posttraumatic stress disorder (PTSD) is unique in its requirement of an external stressor for the development of disease, leading to dysregulated mood, intrusive memories, and avoidance symptoms. Over...

Neurobiology of PTSD: Circuits, Genomics, and Treatment
www.annualreviews.org/content/jour...

Acute and delayed effects of THC on memories of stress in healthy adults - Psychopharmacology Psychopharmacology - Many cannabis users claim that one reason they use cannabis is to relieve stress or dampen effects of stressful memories. However, the processes by which cannabis or its...

Acute and delayed effects of THC on memories of stress in healthy adults
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Pathway-selective signaling of serotonergic psychedelics at 5-HT receptors: Implications for psychoactivity, safety, and therapeutic potential
doi.org/10.1016/j.eu...

Efficacy of N, N-dimethyltryptamine (DMT) psychedelic therapy for substance misuse: A systematic review and meta-analysis - Lisa M. Wallace, Andrea Bujor, Gustavo Sudre, Mark Kennedy, Diana-Elena Bahn... Background: Conventional psychological and pharmacological substance abuse treatments are limited to moderate effect sizes and fail to magnify outcomes when com...

Efficacy of DMT psychedelic therapy for substance misuse: A systematic review and meta-analysis
doi.org/10.1177/0269...

The Ethnopharmacological Use of Mescaline for Psychiatric Disorders: A Systematic Review
doi.org/10.3390/ijms...

The astrocytes in the prefrontal cortex contribute to the rapid antidepressant-like effects of psilocybin in the chronic restraint stress mouse model Psilocybin showed a rapid antidepressant response in several clinical trials, which offers new hope for treating depression. Astrocytes were associate…

The astrocytes in the prefrontal cortex contribute to the rapid antidepressant-like effects of psilocybin in the chronic restraint stress mouse model
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Microglia respond to and induce anxiety and grooming in mice using calcium signaling - Molecular Psychiatry Molecular Psychiatry - Microglia respond to and induce anxiety and grooming in mice using calcium signaling

Microglia respond to and induce anxiety and grooming in mice using calcium signaling
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Pleiotropic modulation of the gut-brain-lung axis by ketamine and its enantiomers - Molecular Psychiatry Molecular Psychiatry - Pleiotropic modulation of the gut-brain-lung axis by ketamine and its enantiomers

Pleiotropic modulation of the gut-brain-lung axis by ketamine and its enantiomers
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Clinical innovations and future directions of nanoparticles in the treatment of psychiatric and neurological disorders - Molecular Psychiatry Molecular Psychiatry - Clinical innovations and future directions of nanoparticles in the treatment of psychiatric and neurological disorders

Clinical innovations and future directions of nanoparticles in the treatment of psychiatric and neurological disorders
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Infant learning forms lasting memory schemas that influence adult behavior Bessières, Prikas, et al. report that episodic-like learning in infant mice establishes enduring memory schemas that guide adult behavior. The schema facilitates relearning and the formation of new, c...

Infant learning forms lasting memory schemas that influence adult behavior
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The Role of Plasticity in Replay: Stability Through Anti‐Hebbian Rules Hippocampal replay is now considered to be a cornerstone of memory consolidation, yet the synaptic plasticity rules governing its dynamics remain elusive. Under the standard asymmetric Hebbian spike-...

The Role of Plasticity in Replay: Stability Through Anti-Hebbian Rules
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Subsets of Single Neurons Predict Ensemble Activity and Memory Choices Finding elements of a complex network which contribute most to the network's overall behavior is an open problem in various fields. This challenge is particularly difficult in neuroscience as it requ...

Subsets of Single Neurons Predict Ensemble Activity and Memory Choices
onlinelibrary.wiley.com/doi/10.1002/...

Single exposure to Ayahuasca reverses chronic stress effects on sociability, anxiety, cortisol, and BDNF in zebrafish - Psychopharmacology Background Chronic stress is a risk factor for the development of anxiety, depression, and comorbid systemic conditions. Ayahuasca (AYA) has been used for hundreds of years and it elicits antidepressa...

Single exposure to Ayahuasca reverses chronic stress effects on sociability, anxiety, cortisol, and BDNF in zebrafish
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BPS Publications G protein-coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990....

GRKs and arrestins: Nomenclature and functions in GPCR-dependent and -independent signalling
bpspubs.onlinelibrary.wiley.com/doi/10.1111/...

Memory deficits of MDMA users are linked to cortical thinning related to 5-HT receptor densities Regular MDMA use is linked to memory dysfunction, but the underlying mechanisms are unclear. Coray et al. found reduced hippocampal grey matter volume in u

Memory deficits of MDMA users are linked to cortical thinning related to 5-HT receptor densities
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General Anesthesia and Discrete Components of Ketamine Neurophysiology This cohort study investigates the association between modulation of ketamine neurophysiologic signatures and removal of conscious awareness using general anesthesia.

General Anesthesia and Discrete Components of Ketamine Neurophysiology
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Serotonergic and glutamatergic mechanisms converge in ketamine’s rapid responses Ketamine’s rapid antidepressant actions are commonly attributed to glutamatergic mechanisms. In a recent study, Luo and colleagues have shown that ketamine inhibits the serotonin transporter and that ...

Serotonergic and glutamatergic mechanisms converge in ketamine’s rapid responses
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Not a Standalone Treatment: Considerations for Psychedelic‐Assisted Therapy External therapists play a pivotal role in supporting patients undergoing psychedelic-assisted therapy (PAT), offering continuity of care, support, and integration. Co-operation and collaboration bet....

Not a Standalone Treatment: Considerations for Psychedelic-Assisted Therapy
doi.org/10.1002/brb3...