Fascinating paper suggesting the assumption that there is a sigmoid dose response relationship and threshold effect ( "all-or-nothing") for loop diuretics rests on repeated misinterpretation of original studies from the 70s and 80s. #nephsky #cardiosky #emimcc academic.oup.com/ehjcvp/artic...
The New England Journal of Medicine European Study of Prostate Cancer Screening — 23-Year Follow-up A Research Summary based on Roobol MJ et al. | 10.1056/NEJMoa2503223 | Published on October 30, 2025 Visual representations of the patients in the trial and the treatments they were assigned. Read the full Research Summary at NEJM.org.
At 23 years of follow-up, population-based PSA screening of asymptomatic men led to a sustained reduction in prostate cancer mortality, although overdiagnosis remains a concern. Full ERSPC study results and Research Summary: nej.md/42YYsg7
#MedSky #Oncology
American Heart Association Scientific Sessions 2025 Original Article | Nov 8, 2025 | NEJM.org Evolocumab in Patients without a Previous Myocardial Infarction or Stroke Figure 1A. 3-Point MACE. The NEJM identity sits at the bottom.
Among patients with atherosclerosis or diabetes but no previous myocardial infarction or stroke, evolocumab led to a lower risk of major adverse cardiovascular events than placebo. Full VESALIUS-CV trial results: nej.md/4oWrIN6
#AHA25
Kaplan–Meier curves of the cumulative incidence of death from any cause, myocardial infarction, or heart failure (the composite primary end point).
In a meta-analysis of 17,801 patients with myocardial infarction and preserved LVEF (≥50%), beta-blockers did not reduce death, MI, or heart failure over a median 3.6 years of follow-up. Full results: nej.md/43U5Ppo
#AHA25
Infographic
New living clinical practice guideline: Cardiovascular, kidney related, and weight loss effects of therapeutics for type 2 diabetes
See our #BMJInfographic for a visual summary of the recommendations
www.bmj.com/content/390/...
Portrait of Edward Jenner leaning against a tree
Happy 276th birthday Edward Jenner! What a time for vaccination: 154 million lives saved in the last 50 years, tempered with an increase in vaccine preventable diseases across the world, vaccine sceptics in charge in the US, and cuts to overseas aid threatening global immunisation programmes.
Exceptionally clear and informative resource.
The risk of venous thromboembolism (VTE) varies across contemporary hormonal contraceptives, with the highest risk associated with combined pills.
#MedSky https://ja.ma/3Y5WQPf
Terminally Ill Adults (End of Life) Bill: call for evidence
here's mine
margaretmccartney.substack.com/p/terminally...
www.parliament.uk/business/new...
Paper in this week's NEJM shows that in patients with atrial fibrillation and stable coronary artery disease, edoxaban monotherapy is superior to the combination of edoxaban plus an antiplatelet drug. Major difference was in bleeding rather than reduction in ischaemic events.
Oral HRT increases venous thrombotic risk (VTE). Tibolone increases arterial but not VTE risk. Topical HRT showed no increase in either. Huge prospective Swedish study: 919,614 women of whom 77,512 started HRT. tinyurl.com/85jxatux #HRT
Disagree. It’s not the NICE decision that’s disappointing , it’s the drug
www.ft.com/content/7762094c-a86d-43...
Excellently articulated opinion piece from former PM Gordon Brown.
Trending in the wrong direction...
#AMR #WAAW24 #PharmSky
pharmaceutical-journal.com/article/news...
MEGA PDF on Incretin therapies by the one and only @drkevinfernando.bsky.social
Very topical at the moment for CRM world
#PharmSky #Medsky #GPsky #CRM #CardioSky
img.medscapestatic.com/vim/live/pro...
Excited to share our recent publication exploring a path forward to retire Cockroft Gault and move towards universal eGFR-based medication dosing decisions, a monumental effort led by Wendy St. Peter and the @nkf-professionals.bsky.social
doi.org/10.1093/ajhp...
CLEAR trial: Should we routinely use Spironolactone after Acute Myocardial Infarction?
No!
#AHA2024
www.nejm.org/doi/full/10....
Yes I've had that thought before too. If no pre-ICS FBC, but eosinophils normal on ICS/LABA, pt stable and no other Hx of inflam resp disease then probably reasonable to try switch. Can always recheck FBC again at later date to check eosinophil trend 👍.
Not a resp expert...
But my understanding is if eosinophils normal + no PMH asthma, then ideally to remove ICS as can inc risk of pneumonia in COPD pts. So yes - switch to LABA/LAMA.
Totally agree - hard to get patients on board when they feel strongly about their existing txt!
GOLD 2025 guidance now available.
No dramatic changes to pharmacological management of COPD from my reading.
#PharmSky #COPD
goldcopd.org/2025-gold-re...
Interesting conclusion from Cochrane. Are we currently over treating BP in this cohort?
Thoughts?
#PharmSky #Pharmacy
SUMMIT trial: “Treatment with tirzepatide led to a lower risk of a composite of death from cardiovascular causes or worsening heart failure than placebo and improved health status in patients with heart failure with preserved ejection fraction and obesity”
www.nejm.org/doi/full/10....
BPROAD trial: “Among patients with T2 diabetes, the incidence of major CVD events was significantly lower with intensive treatment targeting a systolic blood pressure of <120 mm Hg than with standard treatment targeting a systolic blood pressure of <140 mm Hg”
www.nejm.org/doi/full/10....
Useful paper. Fesoterodine's DT price hugely reduced in recent months, so no excuse to prescribe oxybutynin any more based on cost. Fesoterodine now included as 1st line on Somerset Prescribing Formulary
Partisan prophecy: God warning powerless people of their fate if they do not support and defend the cause of the right people in power.
Biblical prophecy: God warning those in power of their fate if they do not support and defend the cause of powerless people.
I understood that BlueSky was supposed to be a 'safer' space than X... On browsing feeds on Christianity/religion, perhaps this is not a safe space after all!
Is there space for people of faith to encourage each other here, or should we move elsewhere?!
#christianity #religion #christian
Year 2 medics are still early on in programme of study... Maybe keep simple? Prescribing - perhaps consider various factors that affect prescription choice (ease of use, availability, cost effectiveness, clinician "favourites"). Deprescribing - lots of good resources such as STOPP/START
