Diagnostic performance varied across the AI platforms evaluated and was generally low to moderate within this small sample. Open access article: jav.ma/aidx

Handful of goofballs showing their ceramic art of varying degrees of talent.

Friendship’s Nephrology-Urology Service goes all out with ceramics! We work together, play together, and now craft together! This team is the best!

A while ago, we launched WormsAndGermsMap, for crowd-based reporting of infectious diseases in companion animals

It didn't really work out, in large part because the tech wasn't ready (at least in our $ range)

But, since tech (and diseases) have advanced, we're trying again
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When cystectomy isn’t an option (trigonal lesions, surgical risk, etc. ) transurethral resection of bladder tumor (TURBT) can also be considered. Currently only offered at a few hospitals in the US. See your local DACVNU for more info!

Partial cystectomy, as part of a multimodal treatment plan including adjuvant medical therapy, can be associated with prolonged survival in select dogs and cats with nontrigonal urothelial carcinoma. Learn more: jav.ma/uc

Interesting findings. But comparison to historical data isn’t ideal. And squeezing in a meta-analysis is a bit much. Especially when there is no assessment for bias risk. Personally, I’m not convinced.

Telmisartan significantly upregulated the activities of superoxide dismutase and glutathione peroxidase, increased total antioxidant capacity, and decreased IL-8 during the 28-day trial in healthy dogs. Open access article: jav.ma/telmisartan2

Yes- horses can get membranous nephropathy! Really nice spikes and holes on the silver stain and subepithelial complexes confirmed on EM. This horse had nephrotic edema and hypoalbuminemia. UPC was 5.8. #vetneph

Today we’re honoring Dr. M. Phyllis Lose, a 1957 graduate of the UPenn who became the first woman to specialize in equine veterinary med. Her career set a new standard for what was possible for women in the field, especially in a specialty that no woman had done.

#WomensHistoryMonth

Love seeing gloms on kidney biopsy tissue! Our old Nikon dissecting microscope is a workhorse!

#NephMadness 2026: Animal House – Cats, Kidneys, and the Art of Surviving on Almost No Water Submit your picks! | @NephMadness | @nephmadness.bsky.social | NephMadness 2026   Autumn Harris At NC State University, Dr. Autumn Harris investigates how kidneys regulate acid-base balance and wha…

NEW #NephMadness Commentary by Autumn Harris on the #AJKDBlog:

Animal House – Cats, Kidneys, and the Art of Surviving on Almost No Water

bit.ly/NM26Harris

#NephMadness 2026: Animal House Region Submit your picks! | @NephMadness | @nephmadness.bsky.social | NephMadness 2026 Selection Committee Member: Autumn Harris  At NC State University, Dr. Autumn Harris investigates how kidneys regulat…

#NephMadness 2026: Animal House Region

Teams: Dogs vs Cats

Experts: Autumn Harris & Kelly Hyndman
Writers: Sarah Street & Susan DiGiovanni
Execs: @kidneywars.bsky.social & @nephrosparks.bsky.social

bit.ly/NM26Animals

Careful assessment of kidney function is recommended in dogs with GDV, as concurrent AKI is common and associated with outcome. Open access article: jav.ma/gdvaki

Nice! Excellent dream pop

This week the American College of Veterinary Nephrology and Urology certified the first 20 diplomates of the college. Congrats to the new DACVNUs! What an amazing landmark for our community!

Genetic mutations found for young (<2 year old) dogs who form CaOx stones.

Frequency of cystine stones is increasing- likely due to recommendations to neuter later in life. Type III cystinuria is androgen dependent and neutering is generally curative.

Dogs and cats metabolize uric acid to allantoin, which is more soluble- hence why dogs and cats don’t have gout!

Eva Furrow discusses metabolism and genetics of urolithiasis. The SLC2A9 mutation associated with urate urolithiasis is linked to spot color. The dogs were bred for looks and resulted in nearly 100% penetration of the mutation in the breed line!

Modifications to the protocol- chemo now before radiation, reducing from 20 to 15 fractions of radiation had similar efficacy and less (18%) incontinence.

Permanent urinary incontinence was seen in 31% of dogs. Median time of onset was 2 months post radiation.

Dr. Nolan presents on radiation treatment of canine bladder cancer.

Gilvetmab is undergoing trials on canine bladder cancer. It may help evade the T-cell exhaustion occurring during chemotherapy.

For patients where surgery is an option (nontrigonal, no urethral or prostate involvement) partial cystectomy would be a great option. Since we often don’t dx UC until they are symptomatic, patient pop is skewed towards those with trigonal and distal lesions.

Since most bladder tumors express a BRAF mutation, directed therapy against BRAF has good PR & CR, but high frequency of cutaneous lesions secondary to upregulation of the targeted pathway.

Dr. Mastromauro reviews alternative therapies for canine bladder cancer.

Application of human treatment paradigm to canine bladder cancer.

So far a false positive hasn’t been identified for the BRAF mutation. All the dogs have had or later developed lesions found on US or cystoscopy. But use in the general dog population with a low incidence of bladder cancer is likely going to be low yield and have a low PPV.

Dr. Hess reviews immunotherapies for bladder cancer immunotherapy.

Using BRAF screening in asymptomatic high risk breeds could detect cancer a median of 149 days prior to the development of clinical signs.