Structure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum AMPA receptors (AMPARs) are multimodal transducers of glutamatergic signals throughout the brain. Their diversity is exemplified in the cerebellum: At afferent synapses, AMPARs mediate high-frequency ...

Now available in final format!
www.science.org/doi/pdf/10.1...

Postdoctoral Scientist - Neurobiology - Dr Ingo Greger - LMB 2802 - Cambridge, Cambridgeshire (GB) job with MRC Laboratory of Molecular Biology (LMB) | 12856831 Postdoctoral Scientist Salary £42,694 per annum Fixed term 3 years MRC Laboratory of Molecular Biology, Cambridge, UK Applications are invited for ...

We are looking for a postdoc experienced with brain slice electrophysiology and imaging approaches:
www.nature.com/naturecareer...

Great new work from Ben Ryskeldi-Falcon's lab on TDB-43
www.biorxiv.org/content/10.6...

A multidisciplinary study from @igreger.bsky.social’s group in the LMB’s Neurobiology Division details the rich diversity of GluA4 AMPA receptors in the cerebellum.
Read more here: www2.mrc-lmb.cam.ac.uk/distinct-amp...
#LMBResearch

Structure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum AMPA receptors (AMPARs) are multimodal transducers of glutamatergic signals throughout the brain. Their diversity is exemplified in the cerebellum; at afferent synapses, AMPARs mediate high-frequency ...

Structure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum | Science www.science.org/doi/10.1126/...

Happy about our new paper in Nature rdcu.be/eukUB
The GluA3 structure provides a framework for understanding this disease-prone glutamate receptor - novel interfaces will provide targets for modulator development

Cryo-EM maps of GluA2/TARP-γ2 (red) and GluA3/TARP-γ2 (green)

New research from @igreger.bsky.social group in the LMB’s Neurobiology Division, show that GluA3 adopts a structural organization that substantially diverges from all the other AMPA receptors.

Read more: www2.mrc-lmb.cam.ac.uk/architecture...

#LMBResearch

Research Support Officer - Neurobiology - Dr Ingo Greger - LMB 2615 - MRC Laboratory of Molecular Biology, Cambridge Apply for the Research Support Officer - Neurobiology - Dr Ingo Greger - LMB 2615 Job, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom. Research Scientist Jobs or Postdocs in Europe fro...

We have an RA opening, for folks interested in molecular neurobiology:
www.eurosciencejobs.com/job_display/...

We are looking for an outstanding postdoctoral researcher to join our team at McGill University. The Sjöström lab studies neocortical circuits, with a focus on synaptic plasticity, NMDA receptor signaling, 2-photon optogenetics, and advanced 2-photon imaging. We are particularly interested in candidates with strong expertise in whole-cell patch-clamp electrophysiology and/or 2-photon imaging, and a solid track record of relevant publications. Applicants should be experienced with whole-cell recordings and/or cutting-edge imaging approaches. Responsibilities will include performing experiments, analyzing and presenting data locally and internationally, writing manuscripts, and occasionally mentoring junior lab members. Our lab is based at the Research Institute of the McGill University Health Centre, in vibrant, multicultural Montreal—a city that offers exceptional quality of life. McGill and its neighbouring universities form one of the most dynamic neuroscience communities in the world. For examples of our current directions, see: • Chou et al The Innovation 2025, www.cell.com/the-innovation/fulltext/S2666-6758(24)00173-5 • Wong et al Neuron 2024, www.cell.com/neuron/fulltext/S0896-6273(23)00767-5 The position is fully funded with a competitive salary. Candidates are also expected to apply for external funding, for which we provide strong support. Opportunities are available for both Canadian and international applicants. To apply, please send a Letter of Intent, CV, brief research statement, and contact information for three referees to Dr. Jesper Sjöström (jesper.sjostrom@mcgill.ca). In the subject line, include "Postdoc" followed by your name. Application deadline: July 31, 2025. Website: http://plasticity.muhc.mcgill.ca McGill University is committed to diversity and equity in employment.

🧪 The Sjöström Lab in Montreal is looking for a postdoc! We study cortical circuits, synaptic plasticity, and NMDAR signalling using custom 2-photon microscopy and optogenetics. We seek candidates with strong patch-clamp and/or 2-photon imaging expertise, and a relevant publication track record.

What a terrific seminar it was..!

Rod MacKinnon Rockefeller University Higher order transient structures and the principles of dynamic connectivity in membrane signaling Monday 7th April at 11am (BST)

Join us at 11am (BST) on Monday 7th April for an #LMBSeminar from Rod MacKinnon of Rockefeller University.
He will be discussing ‘Higher order transient structures and the principles of dynamic connectivity in membrane signaling.’
More details: www2.mrc-lmb.cam.ac.uk/news-and-eve...

John Burn-Murdoch on X: "NEW 🧵 A quick thread of charts showing how Trump’s economic agenda is going so far: 1) Trump has had the same impact on economic uncertainty as a global pandemic. https://t.co/PbthcATkbF" / X NEW 🧵 A quick thread of charts showing how Trump’s economic agenda is going so far: 1) Trump has had the same impact on economic uncertainty as a global pandemic. https://t.co/PbthcATkbF

x.com/jburnmurdoch...

An end to human exceptionalism Our species’ extinction is inevitable, argues a paleontologist

An end to human exceptionalism | Science www.science.org/doi/10.1126/...

Jobs lost in every state and lifesaving cures not discovered: Possible impacts of research cuts Ripple effects of the Trump administration's crackdown on U.S. medical research promise to reach every corner of America.

Interview with me about impact of NIH budget cuts on the American people. It will have ripple effects not only our health but also on state economies across the country.

March in support of science tomorrow!

apnews.com/article/trum...

‘The entire coastline will be cemented over’: the tiny Italian town set to become a dock for giant cruise ships Only 20 miles from Italy’s capital, Isola Sacra was ignored for years but now Royal Caribbean has plans to turn it into a major new port

😵‍💫
www.theguardian.com/environment/...

In @elife.bsky.social: Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP doi.org/10.7554/eLif...

Ingo Greger sat in front of a computer screen displaying an AMPA Receptor structure

Great position for a postdoc to join @igreger.bsky.social’s group in the LMB’s Neurobiology Division, using diverse methods to study synaptic AMPA glutamate receptors.
Read more about the job here: www.nature.com/naturecareer...
Apply by 20 FEB
#PostdocJobs #ScienceJobs

Thousands of trees planted in Devon to start creation of Celtic rainforest More than 2,500 native trees have been planted to form a temperate rainforest in decades to come

nice!
www.theguardian.com/environment/...

Postdoctoral Scientist - Cambridgeshire (GB) job with MRC Laboratory of Molecular Biology (LMB) | 12835302 Postdoctoral Scientist

We're looking for a postdoc with a strong interest in the structure, function and cell biology of glutamate receptors and excitatory synapses.
www.nature.com/naturecareer...

www.science.org/content/arti...

Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP The reward and novelty related neuromodulator dopamine plays an important role in hippocampal long-term memory, which is thought to involve protein synthesis-dependent synaptic plasticity. However, th...

Role of calcium-permeable AMPA receptors in LTP, congrats Tanja!
www.biorxiv.org/content/10.1...

Research Group Leader - Neurobiology - LMB 2531 - Cambridgeshire job with MRC Laboratory of Molecular Biology (LMB) | 12832855 Research Group Leader Starting Salary £50,608 - £58,919 per annum for appointment to Senior Investigator Scientist Salary £65,940 - £74,448 per ann...

The Neurobiology Division at the MRC LMB is looking for a new group leader:
www.nature.com/naturecareer...

Impressive piece of work Jake, congrats!

Simulated mPSC data

Recording synaptic minis (mEPSCs)? We have a new paper trying to better understand how recorded datasets match synaptic changes. In short, they don't..
More info below, and the preprint here:
biorxiv.org/content/10.1101/2024.10.26.620084v1

Model depicting the early steps during production of a membrane protein

Huping Wang and Manu Hegde, in @cellbiol-mrclmb.bsky.social have found a factor that accelerates protein deliveries to the endoplasmic reticulum

Click here to read more about it: www2.mrc-lmb.cam.ac.uk/discovery-of...

#LMBResearch

Join the LMB's PhD programme! Applications now open for October 2025 Deadline 3rd December 2024

Considering a PhD in molecular biology?
There’s still time to apply to join the LMB in October 2024.
Applications close on 3rd DEC.
Visit our website for more info: www2.mrc-lmb.cam.ac.uk/students/int...

Happy CaMKII days in China, with Roger and Howard Schulman