Scientists Map How HIV Hijacks Human Cells—and How Cells Can Fight Back A new genetic roadmap reveals hundreds of hidden players in HIV infection, including two proteins that stop HIV in its tracks.

A team of scientists at Gladstone and UCSF created a new genetic roadmap that reveals hundreds of hidden players in HIV infection, including two proteins that stop HIV in its tracks.

How an Alzheimer's Risk Gene Rewires the Brain Decades Before Symptoms New research reveals how the APOE4 gene disrupts brain circuits early in life, identifying a reversible pathway in Alzheimer's disease.

New research from Yadong Huang’s team reveals how the APOE4 gene disrupts brain circuits early in life, identifying a reversible pathway in Alzheimer’s disease.

Meet MaxToki: The AI That Predicts How Your Cells Age — and What to Do About It A temporal AI model predicts how human cells age and identifies targets to slow age-related disease progression.

Researchers in the lab of Christina Theodoris have built a temporal foundation model that forecasts cell state trajectories across the human lifespan.

New AI Model Predicts How Cells Age

Did you know that you can listen to our latest articles? Check out this episode on a new AI model that predicts how cells age.

Listen on Spotify or wherever you get your podcasts!

Ryan Corces Named 2026 MIND Prize Recipient for Alzheimer’s Disease Research - GeneOnline News Ryan Corces, a researcher at Gladstone Institutes, has […]

The Pershing Square Foundation’s MIND Prize recognizes individuals making significant contributions to neuroscience, cognition, and neurodegenerative disease research. Ryan Corces was selected for his innovative approach to uncovering biological mechanisms that drive Alzheimer’s disease.

Leveraging human genetic variation to therapeutically target hundreds of genes with dominant & dispensable disease alleles - PubMed Here we identify a novel therapeutic opportunity for over 500 genes with putative "dominant & dispensable" (D&D) disease alleles. In these haplo <i>sufficient</i> genes, a single functional allele may...

Cool new work from my @gladstoneinst.bsky.social and @ucsanfrancisco.bsky.social on haplosufficient genes
pubmed.ncbi.nlm.nih.gov/41929339/

🌟 A big thank you to our April Reviewer of the Month, Dr Kruthika Iyer, for her contributions to our scientific community! Dr Iyer is a Bioinformatics Fellow at @gladstoneinst.bsky.social, whose work focuses on the genetic architecture of aging and complex disease.

www.nature.com/commsbio/ref...

Discovery Spotlight│New AI Model Predicts How Cells Age YouTube video by Gladstone Institutes

Gladstone scientists, in collaboration with NVIDIA, developed a new AI model—MaxToki—that can predict how individual cells change as we age. By analyzing gene activity across the human lifespan, this model is helping uncover the genes that drive aging and age-related diseases.

How an Alzheimer’s Risk Gene Rewires the Brain Decades Before Symptoms New research reveals how the APOE4 gene disrupts brain circuits early in life, identifying a reversible pathway in Alzheimer’s disease.

New research from Yadong Huang’s team reveals how the APOE4 gene disrupts brain circuits early in life, identifying a reversible pathway in Alzheimer’s disease.

Surprising links between autism, Alzheimer's could change how we treat both The idea that two conditions at opposite ends of life might be biologically linked is beginning to upend long-standing assumptions in brain science, blurring a divide that has shaped the field.

Lennart Mucke shares insights on the potential biological connections between two very different neurological conditions.

Biotechs nibble into sublease market as rents drop, landlords compete for tenants - San Francisco Business Times Biotechs are nibbling into the sublease market as landlords compete for tenants and rents drop.

"It's not just a building. It's more than space. It represents an opportunity to scale our impact on solving the diseases we're focused on at Gladstone."

Deepak Srivastava talks about Gladstone's expansion in Mission Bay.

Last week, we welcomed Daniel J. Drucker for the Lloyd “Holly” Smith Distinguished Lecture, where he shared the science behind GLP-1 medicines and their growing impact across human health.

Thanks to everyone who joined us and helped make it such an engaging event.

Cracking the Code of Disease with AI YouTube video by Gladstone Institutes

What if we could finally understand which tiny changes in our DNA actually cause disease?

Gladstone scientists are bringing together cutting-edge AI models and powerful molecular tools to tackle one of the biggest challenges in science: decoding the human genome.

Scientists Find a Better Way to Make CAR-T Cells YouTube video by UC San Francisco (UCSF)

Scientists have found a way to create cancer killing CAR-T cells inside the body. This eliminates the costly, time-consuming manufacturing process that has kept these therapies out of reach of cancer patients around the world.

@j-eyquem.bsky.social

Discovery Spotlight | Overworked Brain Cells May Burn Out in Parkinson’s Disease YouTube video by Gladstone Institutes

On World Parkinson’s Day, we’re shining a light on the science behind Parkinson’s disease—and what it could mean for future treatments.

How AI Is Accelerating Life-Saving Discovery Gladstone scientists are developing new AI tools that promise to revolutionize how science is done and lead to new treatments for the most devastating diseases.

Learn more about how scientists are using AI.

Their platforms are paving the way to new treatments and medicines for some of the harshest diseases, from Alzheimer’s to cancer to HIV.

At Gladstone, a leader in this fast-moving field, our scientists aren’t simply using artificial intelligence in their work—they’re creating some of the world’s most advanced AI models in biomedical research.

Scientists, too, are using AI to better understand how human bodies work and what goes wrong in disease. Yet, the use of AI in science remains a bit of a mystery for the average person.

Artificial intelligence, or #AI, is all around: it can draft emails, control your home thermostat, generate videos, and even drive cars. 🧵

amfAR Launches $2 Million AI-Enabled, Collaborative Study to Map the HIV Reservoir A groundbreaking effort aimed at transforming scientific understanding of how the virus disrupts immune function and persists in the body throughout treatment.

Melanie Ott and Nadia Roan are central to a groundbreaking effort to create the world’s first map of how HIV affects the immune system at a single-cell level.

Gladstone's Ryan Corces Receives MIND Prize to Uncover Unknown Drivers of Alzheimer's The prize, issued annually to eight scientists, seeks to catalyze high-impact neuroscience research.

👏 👏 Congratulations to Gladstone investigator @ryancorces.bsky.social who has been named a 2026 winner of the Pershing Square Foundation’s MIND Prize.

This award recognizes next-frontier thinkers who are uncovering a deeper understanding of the brain and cognition.

New AI Model Predicts How Cells Age Trained on data spanning the human lifespan, a new tool developed at Gladstone can predict genes associated with aging and age-related diseases.

MaxToki, a new AI model developed at @gladstoneinst.bsky.social, learned how every cell type in the body ages. Now, it can predict which genes drive that aging, pointing toward new targets for heart disease and dementia. gladstone.org/news/new-ai-...

Such an amazing lecture from @danieljdrucker.bsky.social for our annual Holly Smith Distinguished Lecturer for 2026 @gladstoneinst.bsky.social

Gladstone Institutes Expands with Lease at Mission Bay Megacampus - Connect CRE Gladstone Institutes has secured more than 105,000 square feet of future laboratory space in a newly constructed building at 1450 Owens St. in San Francisco, part of the Alexandria Center for Science ...

Learn more about Gladstone's big expansion ⤵️ ⤵️

Two decades of induced pluripotent stem cell research: From discovery to diverse applications Since the discovery of induced pluripotent stem cells (iPSCs) 20 years ago, iPSC technology has transformed stem cell research and regenerative medicine. This perspective reviews key advances in repro...

🚨 NEW 🚨

"Two decades of induced pluripotent stem cell research: From discovery to diverse applications" by Shinya Yamanaka

What if AI didn’t just give answers—but helped scientists ask better questions?

At Gladstone, researchers like Seth Shipman are pushing AI and molecular tools to uncover what we don’t yet understand about disease—and turn uncertainty into insight.

It’s Graduate Student Appreciation Week!

Our graduate students push ideas forward, navigate challenges with creativity, and ask the questions that lead to what’s next. Just as importantly, they bring a spirit of collaboration that makes Gladstone thrive.

Cell Signals│Investing in the Future of Medicine In today's newsletter, explore Gladstone's exciting expansion and what it means for the future of science, see how a new AI-powered approach is helping pinpoint the genetic causes of disease, and discover research that could pave the way toward life wit...

In our latest newsletter, explore Gladstone’s exciting expansion, see how a new AI-powered approach is helping pinpoint the genetic causes of disease, and discover research that could pave the way toward life without daily HIV medication using a common diabetes drug.

Decoding the Tumor: Inside the AI-Driven Hunt for Colorectal Cancer Immunotherapy - Cancer Research Institute Discover how AI-driven research is uncovering how tumors evade immunity, paving the way for new colorectal cancer immunotherapies that could benefit more patients.

For most colorectal cancer patients, immunotherapy still falls short.

Karin Pelka is on a mission to change that—using AI to decode tumors and reveal the hidden signals that could make treatments work for more people.


@pelkalab.bsky.social