Important statement on using GLI vs. GOLD spirometry criteria for the diagnosis of #COPD

publications.ersnet.org/content/erj/...

New horizons in systemic sclerosis treatment: advances and emerging therapies in 2025 Systemic sclerosis (SSc) is a rare, multisystem autoimmune disease characterised by vasculopathy, immune dysregulation, and progressive fibrosis, leading to significant morbidity and mortality. While ...

Excellent review on modern therapeutic options available for #scleroderma
rmdopen.bmj.com/content/11/3...

There are no Piranhas in Africa

Brian May plays Queen's '39' at the 2014 Starmus Festival YouTube video by Astronomy magazine

Mixing science with music
'39

youtu.be/K9jvseJDN2k?...

The importance of bedside teaching of #Medicine
#MedicinePractice #MedicalEducation
www.nejm.org/doi/full/10....

What Drives Lung Cancer in Nonsmokers? Lung cancer among nonsmokers is associated with germline risk factors, and EGFR/ALK-targeted therapies provide substantial benefit, a review finds.

What Drives #LungCancer in Nonsmokers?
This is rapidly growing clinical problem

www.medscape.com/viewarticle/...

Efficacy and safety of nipocalimab in patients with moderate-to-severe Sjögren's disease (DAHLIAS): a randomised, phase 2, placebo-controlled, double-blind trial Fc receptor blockade by nipocalimab 15 mg/kg significantly improved clinical disease activity versus placebo and was safe and well tolerated in participants with moderate-to-severe, active Sjögren's d...

Sjogren disease therapy making nice progress since I reviewed pilocarpine for xerostomia in SS 25 years ago. Read "research in context" box.
www.thelancet.com/journals/lan...

Very interesting 👇

small vessel vasculitis-necrosis?

Antifibrotic therapy does not alter the natural history of #pulmonaryhypertension in #pulmonaryfibrosis and other #progressivePF #fibroticILD

bmcpulmmed.biomedcentral.com/articles/10....

The prognostic importance of worsening dyspnoea in systemic sclerosis related interstitial lung disease To determine the prognostic importance of worsening dyspnoea in systemic sclerosis (SSc) related interstitial lung disease (ILD).SSc patients were rec…

Dyspnea worsening is a strong predictor of ILD progression in #Scleroserma and unlinked to changes in pulmonary function test
www.sciencedirect.com/science/arti...

Association between FDG accumulation in interstitial lesions and acute exacerbation risk in lung cancer: multicenter analysis - Japanese Journal of Radiology Purpose Interstitial pneumonia (IP) is associated with poor prognosis in lung cancer and increases the risk of acute exacerbation (AE). Few studies analyzed the relationship between fluorodeoxyglucose...

FDG accumulation (or lack of uptake) within interstitial lesions does not predict acute exacerbation risk in lung cancer
#pulmonaryfibrosis
link.springer.com/article/10.1...

Inhaled Recombinant human GM-CSF given 48w shows clinically significant ,around 10% rise in DLCO, with some yet not statistically significant improvement in QOL or Exercise capacity in #alveolarproteinosis #raredisease

Our dog is inspired in her sleep, dreaming and runnig while I listen to an old lecture from the late Prof. Brian Whipp
#ExercisePhysiology #ExerciseTesting
#ERSCongress 2007

Effect of Admilparant, a Lysophosphatidic Acid Receptor 1 Antagonist, on Disease Progression in Pulmonary Fibrosis These findings support further evaluation of admilparant as a therapeutic option for patients with IPF or PPF in phase 3 trials.

Another therapeutic option for #pulmonaryfibrosis is coming up: Admilparant, a Lysophosphatidic Acid Receptor 1 Antagonist for IPF and PPF
journal.chestnet.org/article/S001...

All is good. Would reclassification help us to adjust optimal treatment and improve outcomes and clinical decisions? I sure hope so.
publications.ersnet.org/content/erj/...

Calcium Supplementation, Genetic Susceptibility, and Idiopathic Pulmonary Fibrosis Risk: A Prospective Study The association between calcium supplementation and the risk of incident idiopathic pulmonary fibrosis (IPF) is largely unknown.This study aimed to in…

Intriguing findings suggest that #Calcium Supplementation and even more together with Genetic Susceptibility may increase the incidence of Idiopathic #PulmonaryFibrosis.
A prospective cohort study.
www.sciencedirect.com/science/arti...

Seems my point is well taken. Injury, enforces abstaining from exercise or modifications that compromise benefit on mitochondria.

I presume there is a J-curve in which heavy repeated load may have eventually a toll on the integrity and function of joints and supporting soft tissue.

How come with increased wisdom and knowledge in this age there is more idiocy?

A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss - Nature Metabolism In this study, the authors describe SANA, a nitroalkene derivative of salicylate, as a potential activator of creatine-dependent energy expenditure and thermogenesis in adipose tissue. Preclinical and...

A new approach to achieve weight loss, by increasing thermogenesis and promoting metabolism
www.nature.com/articles/s42...

the effect on 'later life' is valid if you maintain a life long training pattern

On the Cover of @annalsats.bsky.social a picture of the pediatric department from which the senior author of this paper comes. The building was savagely attacked by an Iranian missile On June the 19th.

Dupilumab and #lymphoma risk among patients with #asthma: a population-based cohort study #BiologicsAsthma
Increased incidence of T and NK cell lymphoma and CTCL.
Clinical implications, yet to be determined.
publications.ersnet.org/content/erj/...

פגיעת הטיל האיראני במכון ויצמן: "יש מעבדות שאיבדו הכול" הטיל האיראני שפגע השבוע במכון ויצמן למדע שברחובות גרם נזק כבד והותיר לא מעט לבבות שבורים של מיטב המוחות המדעיים בישראל. מתוך השבר הנורא נולדה מחויבות לשיקום המחקר. פרופ' אלדד צחור, חוקר מחלות לב: "המע...

On the devastating damage the researchers at Weizmann institute sustained from an Iranian missle

www.ynet.co.il/health/artic...

Impact of Environmental Exposures on the Development and Progression of Fibrotic Interstitial Lung Disease <p>Dr. Mohleen Kang chats with Dr. Kerri Johannson and Dr. Tamera Corte about their article, "<a rel="nofollow"href="https://www.ats...

An @atscommunity.bsky.social podcast on environmental factors contributing to interstitial lung disease #pulmonaryfibrosis #fibroticILD
castbox.fm/app/castbox/...

Rentosertib, A generative AI-discovered TNIK inhibitor for idiopathic #pulmonaryfibrosis: a randomized phase 2a trial
Interesting if consistently confirmed effective, seems to have a relatively small rate of GI side effects.
www.nature.com/articles/s41...

So banal and so understanable.

Remarkable: a treatment for progressive pulm. fibrosis #fibroticILD. #Nerandomilast a molecule with #antifibrotic and anti-inflammatory effect, slows down FVC deterioration. Additionally, a weak signal of benefit on secondary end points, seen beyond week 52 of therapy.
www.nejm.org/doi/full/10....

Nerandomilast slows FVC deterioration in IPF patients without/with background #antifibrotic therapy.
- No additional protection from IPF exacerbation
- Pirfenidone decreases plasma levels of Nerandomilast by 50% as opposed to nintedanib.
#pulmonaryfibrosis #ATS2025
www.nejm.org/doi/full/10....