Acute generalized exanthematous pustulosis:
Acute generalized exanthematous pustulosis is a severe adverse drug reaction characterized by sterile pustules.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.251459

Behavioural nudges to reduce low-value care:
Nudges — including waiting room information posters targeting patients and electronic health record alerts targeting clinicians — did not reduce low-value care for low back pain in emergency departments.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.251595

Winter scene with snow covered ground and small colourful buildings in Salluit, Canada

Tuberculosis in the 21st century: what are the Nunavimmiut experiences of care?

New articles on Inuit experiences of and expertise on the tuberculosis epidemic; cognitive dysfunction and multiple sclerosis; promoting reconciliation through research, and more.
➡️ https://www.cmaj.ca/content/198/13

But are you sure? As a fourth-year medical student in the ’80s, I knew a little bit about most things medical, but not a lot about anything. I knew familial polyposis was a horrible condition you don’t want to have. As a teenager, you develop multiple intestinal polyps, usually in your colon, which start out

But are you sure?:
A retired physician reflects on his first experience of a patient having an unexpected bad outcome.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.251469

Preparing Canada’s health system for conflict: a framework for civilian–military medical readiness Key points A major armed conflict involving Canada or its North Atlantic Treaty Organization (NATO) allies, including coalition ground combat with large-scale casualty repatriation to Canadian hospitals, could overwhelm Canada’s civilian health system well before it strains the country’s

Civilian-military medical readiness:
Canada’s civilian health system would likely bear the clinical burden of large-scale casualty events involving Canadian or allied forces.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.252067

Drug-induced Raynaud phenomenon following initiation of metoprolol succinate A 69-year-old man with hypertension and hyperlipidemia presented to the emergency department with exertional angina. Coronary artery catheterization demonstrated 80% stenosis in the left anterior descending artery. After stent placement, he was started on acetylsalicylic acid, clopidogrel, and

Drug-induced Raynaud phenomenon:
Raynaud phenomenon has been linked to more than 562 medications, with vasoactive nervous system agents, cardiovascular drugs, and immunomodulators among the most implicated medications.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.251476

Orthostatic hypotension in Parkinson disease Parkinson disease affects 3.2 to 3.6 per 1000 people living in Canada. Orthostatic hypotension occurs in an estimated 36% of people with Parkinson disease;[1][1] it increases fall risk 10-fold[2][2] and nearly triples patients’ risk of cognitive impairment.[3][3] It can be symptomatic (e.g.,

Orthostatic hypotension in Parkinson disease:
Orthostatic hypotension is commonly associated with Parkinson disease, posing serious risks to patients.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.251661

Transformative therapies for sickle cell disease Key points Sickle cell disease (SCD) occurs when a DNA base pair substitution in the β-globin gene results in the formation of hemoglobin S, which polymerizes when deoxygenated, leading to deformation (“sickling”) and hemolysis of red blood cells. Sickle cell disease results in recurrent acute

Transformative therapies for sickle cell disease have the potential to decrease morbidity and mortality, and as these therapies become more available, more patients in Canada will be offered these therapies earlier in the disease course.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.251338

Management of brain–heart multimorbidity guideline:
This clinical practice guideline expands on current cardiovascular guidelines to include evidence from the neurologic and mental health literature.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.251137

Sickle cell disease: what are the novel treatments?

New articles on transformative therapies for sickle cell disease; civilian–military medical readiness; management of brain–heart multimorbidity guideline, and more.
➡️ https://www.cmaj.ca/content/198/12

When the body forgets the self In medicine, we learn to view the body as a map, with territories drawn in clean ink and borders fixed with certainty. Each structure has a Latin name, and every deficit matches a lesion. The diagrams promise stability: neat arrows and crisp pathways. Under fluorescent light, my shadow aligns

When the body forgets the self:
A medical student reflects on how illness influences patients' awareness of space.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.251841

Navigating vaccine hesitancy as a woman recently arrived in Canada: a journey of building trust When I arrived in Canada from Ethiopia in 2018, I believed in vaccines. I grew up in Addis Ababa, but my parents are Eritrean, so I have a diverse background. My childhood memories include lining up at local clinics for vaccines. For example, lots of people were excited to get the polio vaccine

Vaccine hesitancy and building trust:
"When I hear people repeat that vaccines are “safe and effective,” it feels like they’re oversimplifying something that involves personal reflection and trust."
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.250383

Low-income families Vulnerable populations — such as people in Indigenous or rural communities, people with disabilities, or those with insecure housing — face increased barriers to filing tax returns. Filing is often required to access benefits such as Canada Child Benefits, housing supports, daycare subsidies,

Supporting low-income families:
Families should be encouraged to file their taxes to access benefits, such as Child Benefits, housing supports, daycare subsidies, and food assistance.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.251684

Autism spectrum disorder and co-occurring schizophrenia A recent meta-analysis found that autistic individuals have a higher prevalence of these disorders (e.g., schizophrenia, schizoaffective, delusional), at 4%, than the general population, at 0.46%.[1][1] Larger studies of autistic individuals with intellectual disability report higher prevalence of

Autism and co-occurring schizophrenia:
Schizophrenia spectrum disorders are more common in autistic individuals than in the general population.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.250921

Management of chronic kidney disease in a 65-year-old man with diabetes A 65-year-old man with hypertension, type 2 diabetes, a remote myocardial infarct, and chronic kidney disease (CKD) presents for routine follow-up with his family physician. Two years prior, the patient’s CKD was investigated by a nephrologist and attributed to diabetes. At that time, his

Chronic kidney disease and diabetes:
In patients with chronic kidney disease and diabetes, medication adjustments should optimize treatments with established cardiovascular and kidney benefit in addition to achieving glycemic control targets.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.251577

40% of severe pregnancy complications are missed, McMaster University study says | Watch News Videos Online Watch 40% of severe pregnancy complications are missed, McMaster University study says Video Online, on GlobalNews.ca

Published today in @cmaj.ca: SERENE researchers report severe maternal morbidity in Canada is more common than previously estimated. globalnews.ca/video/117334...

High stakes: online gambling and the rise in harm

On the latest episode of #CMAJPodcasts, Drs. Tara Gomes and Ashley White discuss the rising treatment of adult ADHD and how the condition can go unrecognized in high-performing adults.
➡️ www.cmaj.ca/transcript-251065

Emergency care physician, health equity advocate, and investigative journalist Dr. Blair Bigham receives 2026 Agnes Macphail Award News Release March 23, 2026 Yesterday, the City of Toronto and Mayor Olivia Chow honoured Dr. Blair Bigham, an emergency and critical care physician, academic, and investigative health journalist, as ...

🎉 Congratulations to Dr. Blair Bigham — emergency and critical care physician, health‑equity advocate, investigative journalist, and co‑host of the CMAJ Podcast — on receiving the 2026 Agnes Macphail Award!

Learn more ➡️ www.toronto.ca/news/emergen...

Low-income families: how can physicians provide support?

New articles on supporting low-income families; cost-related prescription nonadherence; chronic kidney disease and diabetes, and more.
➡️ https://www.cmaj.ca/content/198/11

Racial disparities in obstetric trauma — defined as severe injury to the perineum, cervix,
vagina, or surrounding pelvic structures during childbirth — varied by immigrant class and were attenuated as duration of maternal residence in Canada increased.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.250633

On the latest episode of #CMAJPodcasts, Dr. Daniel Myran reports that gambling addiction hotline contacts among young males tripled after the market opened to private operators, and Dr. Daniela Lobo describes seeing younger patients since the introduction of iGaming.
➡️ www.cmaj.ca/transcript-251894

Pregnant woman in a hospital gown lying down on exam table. Doctor palpates her exposed abdomen to verify the position of the baby.

Severe maternal morbidity: what are recent trends in Canada?

New articles on severe maternal morbidity; obstetric trauma; dalbavancin, and more.
➡️ https://www.cmaj.ca/content/198/10

Between:
A physician reflects on a patient's courage and autonomy when facing terminal illness.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.251539

Palmoplantar lichen planus:
Palmoplantar lichen planus is an uncommon variant of lichen planus that typically lacks the characteristic fine, reticulated white lines (Wickham striae).
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.251473

On #CMAJPodcasts, Drs. Megan Cooney and Matthew Carwana discuss how the TEN‑4‑FACESp rule helps identify bruising patterns concerning for physical abuse, and what pandemic-era hospitalization trends reveal about the severity of maltreatment in infants and toddlers.
➡️ www.cmaj.ca/transcript-251219

D-dimer testing:
D-dimer test results can be combined with clinical pretest probability to avoid unnecessary imaging.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.251356

Closeup of hand holding a prescription bottle of lisdexamfetamine

Prescription stimulants: what are the trends?

New articles on prescription stimulants before and during the pandemic; d-dimer testing; palmoplantar lichen planus, and more.
➡️ https://www.cmaj.ca/content/198/9

A parallel private-pay system will worsen access to publicly funded surgery Key points The government of Alberta recently announced legislative changes allowing patients to self-refer and pay out of pocket for diagnostic and testing services covered by publicly funded health ...

A new @cmaj.ca article also highlights the evidence on private payment for medical care:

Alberta's "new legislation is highly unlikely to reduce public wait times and almost certain to increase inequity ...
Other provinces should avoid following Alberta’s example"

www.cmaj.ca/content/198/... 🧵

I know you’ll understand “Oh, when I saw that I was getting a colonoscopy, I just assumed you’d be a man. I’m so glad to see a woman is going to be doing my procedure today. I just feel more comfortable around female doctors....

I know you’ll understand:
A transgender woman physician reflects on her encounters with female patients
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.251220

A parallel private-pay system will worsen access to publicly funded surgery Key points The government of Alberta recently announced legislative changes allowing patients to self-refer and pay out of pocket for diagnostic and testing services covered by publicly funded health ...

Parallel private-pay system:
Evidence indicates that a parallel private-pay health care system does not reduce wait times in the public system, because scarce human resources move into the private system and private-pay patients are prioritized.
➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.252077